Background:Neoadjuvant chemotherapy plays a vital role in the treatment of advanced gastric cancer(GC),however,optimizing its effectiveness remains an important research focus.Traditional Chinese medicine(TCM),a promi...Background:Neoadjuvant chemotherapy plays a vital role in the treatment of advanced gastric cancer(GC),however,optimizing its effectiveness remains an important research focus.Traditional Chinese medicine(TCM),a promising adjunctive therapy,has shown enhanced clinical outcomes when combined with postoperative adjuvant chemotherapy.Therefore,this study is designed to evaluate the clinical efficacy of Yiqi Huayu Jiedu decoction combined with neoadjuvant chemotherapy FLOT in the treatment of advanced GC.Methods:This study is a prospective,double-arm,randomized controlled trial.It involves a total of 260 patients diagnosed with advanced GC,who will be randomly assigned to two groups-a TCM treatment group and a control group,each comprising 130 patients.All patients will receive standard FLOT chemotherapy,and patients in the TCM treatment group will additionally receive TCM treatment with Yiqi Huayu Jiedu decoction.After four cycles of chemotherapy,GC D2 radical surgery will be performed.The primary objective is to evaluate the postoperative pathological response rate of the tumor.The secondary objectives include evaluating the perioperative nutritional status,the efficacy of TCM syndrome,and adverse events associated with both chemotherapy and surgery.Discussion:Currently,no trials have investigated the impact of TCM in combination with neoadjuvant chemotherapy on the preoperative treatment in patients with advanced GC.Accordingly,it is imperative to conduct this prospective study to evaluate the clinical efficacy and safety of this regimen,meanwhile providing high-level clinical evidence for TCM combined with neoadjuvant chemotherapy and introducing an innovative regimen for preoperative comprehensive treatment of GC.展开更多
Two furostanol saponins were obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Their structures were determine...Two furostanol saponins were obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Their structures were determined as (25S)-26-O-(β-D-glucopyranosyl)- furost-1β, 3β, 22α, 26-tetrol-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (1) and (25R)- 26-O-(β-D-glucopyranosyl)-furost-1β, 3β 22a, 26-tetrol 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 2)-β-D-glu- copyranoside (2), on basis of chemical and spectroscopic evidences. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophages of the rat abdomen induced by LPS at 20 μg/mL.展开更多
A new cytotoxic saponin(1). Julibrosides J(27), was isolated from the stem barks of Alibizia. julibrissin by chromatography, and the structure was elucidated as 3-O-beta-D-xylopyranosyl-(1-->2)-beta -D- fucopyranos...A new cytotoxic saponin(1). Julibrosides J(27), was isolated from the stem barks of Alibizia. julibrissin by chromatography, and the structure was elucidated as 3-O-beta-D-xylopyranosyl-(1-->2)-beta -D- fucopyranosyl - (1-->6) -beta -D-glucopyranosyl - 21-O-[(6S)-2 -trans-2-hydroxymethyl-6-methyl-6-O- [4-O-((6S)-2-trans-2-hydroxylmethy 6- methyl - 6- hydroxy)-2,7-octadienoyl-beta-D-quinovopy- -ranosyl]-2.7-octadienoyl}- acacic acid- 28 -O-beta-D-glucopranosyl-(1-->3)-[(alpha-L-arabinofuranosyl-(1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyrnosyl ester based on spectral and chemical evidences.展开更多
A furostanol saponin was obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Its structure was determined as 3-O...A furostanol saponin was obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Its structure was determined as 3-O-β-D-glucopyranosyl-(25S)-22-O-methyl-5β-furost-1β, 3β, 5β, 22α; 26-pentaol-26-O-β-D-glucopyranoside (1) on the basis of chemical and spectroscopic evidences. The n-butanol fraction displayed marked inhibitory activity in vitro towards HeLa and HL-60 human tumor cell lines by MTT method.展开更多
The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids.The rheological behavior of aqueous lubricating fluids with PPM has bee...The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids.The rheological behavior of aqueous lubricating fluids with PPM has been characterized to confirm PPM’s function as a viscosity modifier.The tribological behavior of aqueous lubricating fluids with PPM has been investigated on SRV-V and MTM testing machines.It was found that PPM has excellent viscosity-increasing,lubricating,and anti-wear properties as an additive for aqueous,which can be attributed to the ability of PPM to form the protective film and boundary tribofilm generated from complex tribochemical reaction on rubbing surface.The obtained PPM with dual functions of anti-corrosion additives and viscosity index improver can play an important role in diverse lubrication regimes.展开更多
Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis(RA).In a continuous research aiming at discovery of sinomenine derivates with better bioactivity,a cross-coupling reaction of sinom...Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis(RA).In a continuous research aiming at discovery of sinomenine derivates with better bioactivity,a cross-coupling reaction of sinomenine and 1,2-dihydroxybenzene catalyzed by a fungus Coriolus unicolor afforded an unique C-C cross-coupled compound 2,together with(S)-disinomenine and (R)-disinomenine.The structure of 2 was elucidated by MS and NMR spectroscopy.Compound 2 was further assayed for the inhibitory activity on IL-6 overproduction in SW982 cells and exhibited a much more potent activity on IL-6(96%inhibition) compared with those of(S)-disinomenine and sinomenine(17%and 12%inhibition,respectively).展开更多
Eleven triazolyl substituted tetrahydrobenzofuran derivatives were synthesized in high yields as novel H+/K+- ATPase inhibitor via one-pot Cul-catalyzed three-component click reaction of azide, secondary amine and 3...Eleven triazolyl substituted tetrahydrobenzofuran derivatives were synthesized in high yields as novel H+/K+- ATPase inhibitor via one-pot Cul-catalyzed three-component click reaction of azide, secondary amine and 3-bromopropyne under mild conditions in water. Their structures were characterized by NMR, IR, ESI-MS, ele- mental analysis and single-crystal X-ray diffraction analysis. Most of the target compounds exhibited better H+/K+- ATPase inhibitory activity than commercial omeprazole with IC50 values less than 15 gmol'L-~. The initial struc- ture-activity analysis suggested that the triazole substituted by cycloalkyl, aromatic ring or O-containing side-chain seemed to be beneficial for enhancing the activity.展开更多
The surface force apparatus (SFA) plays a key role in research of nano-technology. A new SFA is introduced. With this apparatus, the theories about non-adhesion and adhesion contact were studied. The experiments showe...The surface force apparatus (SFA) plays a key role in research of nano-technology. A new SFA is introduced. With this apparatus, the theories about non-adhesion and adhesion contact were studied. The experiments showed the agreement between Hertz and non-adhesion contact. The JKR theory approximately accords with the experiment.展开更多
7-epi-Taxane has been achieved efficiently in gram scale from natural taxane via inversion of the 7-hydroxyl group simply using Ag20 as catalyst and DMF as solvent. The catalyst could he quantitatively recovered by fi...7-epi-Taxane has been achieved efficiently in gram scale from natural taxane via inversion of the 7-hydroxyl group simply using Ag20 as catalyst and DMF as solvent. The catalyst could he quantitatively recovered by filtra- tion without loss of catalytic activity. This condition is also applicable to the direct epimerization of taxane derivatives (e.g., docetaxel and paclitaxel) to 7-epi-taxane derivatives (e.g., 7-epi-docetaxel and 7-epi-paclitaxel). Furthermore, 33 ester derivatives of 7-epi-taxane with different amino acid moieties at the position of C-13 were successfully synthesized via esterification without protecting C-7-OH. Bioassay results revealed that compounds 13 and 18 have good selectivity against prostatic cancer cell line DU145, with ICs0 value as low as 15.9 nmol/L for 18.展开更多
The nanofriction properties of hexagonal boron nitride(h-BN)are vital for its application as a substrate for graphene devices and solid lubricants in micro-and nano-electromechanical devices.In this work,the nanofrict...The nanofriction properties of hexagonal boron nitride(h-BN)are vital for its application as a substrate for graphene devices and solid lubricants in micro-and nano-electromechanical devices.In this work,the nanofriction characteristics of h-BN on Si/SiO_(2) substrates with a bias voltage are explored using a conductive atomic force microscopy(AFM)tip sliding on the h-BN surface under different substrate bias voltages.The results show that the nanofriction on h-BN increases with an increase in the applied bias difference(V_(t–s))between the conductive tip and the substrate.The nanofriction under negative V_(t–s) is larger than that under positive V_(t–s).The variation in nanofriction is relevant to the electrostatic interaction caused by the charging effect.The electrostatic force between opposite charges localized on the conductive tip and at the SiO2/Si interface increases with an increase in V_(t–s).Owing to the characteristics of p-type silicon,a positive V_(t–s) will first cause depletion of majority carriers,which results in a difference of nanofriction under positive and negative V_(t–s).Our findings provide an approach for manipulating the nanofriction of 2D insulating material surfaces through an applied electric field,and are helpful for designing a substrate for graphene devices.展开更多
基金This study has been approved by the Ethics Committee of Jiangsu Provincial Hospital of Traditional Chinese Medicine(Ethical approval number:2023NL-046-02)registered with the Chinese Clinical Trial Registry(Registration number:ChiCTR2300072742).
文摘Background:Neoadjuvant chemotherapy plays a vital role in the treatment of advanced gastric cancer(GC),however,optimizing its effectiveness remains an important research focus.Traditional Chinese medicine(TCM),a promising adjunctive therapy,has shown enhanced clinical outcomes when combined with postoperative adjuvant chemotherapy.Therefore,this study is designed to evaluate the clinical efficacy of Yiqi Huayu Jiedu decoction combined with neoadjuvant chemotherapy FLOT in the treatment of advanced GC.Methods:This study is a prospective,double-arm,randomized controlled trial.It involves a total of 260 patients diagnosed with advanced GC,who will be randomly assigned to two groups-a TCM treatment group and a control group,each comprising 130 patients.All patients will receive standard FLOT chemotherapy,and patients in the TCM treatment group will additionally receive TCM treatment with Yiqi Huayu Jiedu decoction.After four cycles of chemotherapy,GC D2 radical surgery will be performed.The primary objective is to evaluate the postoperative pathological response rate of the tumor.The secondary objectives include evaluating the perioperative nutritional status,the efficacy of TCM syndrome,and adverse events associated with both chemotherapy and surgery.Discussion:Currently,no trials have investigated the impact of TCM in combination with neoadjuvant chemotherapy on the preoperative treatment in patients with advanced GC.Accordingly,it is imperative to conduct this prospective study to evaluate the clinical efficacy and safety of this regimen,meanwhile providing high-level clinical evidence for TCM combined with neoadjuvant chemotherapy and introducing an innovative regimen for preoperative comprehensive treatment of GC.
基金financially supported by the National Natural Science Foundation of China(No.30670213)Key Scientific Program of China Three Gorges University(No.2005ZD007).
文摘Two furostanol saponins were obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Their structures were determined as (25S)-26-O-(β-D-glucopyranosyl)- furost-1β, 3β, 22α, 26-tetrol-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (1) and (25R)- 26-O-(β-D-glucopyranosyl)-furost-1β, 3β 22a, 26-tetrol 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 2)-β-D-glu- copyranoside (2), on basis of chemical and spectroscopic evidences. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophages of the rat abdomen induced by LPS at 20 μg/mL.
文摘A new cytotoxic saponin(1). Julibrosides J(27), was isolated from the stem barks of Alibizia. julibrissin by chromatography, and the structure was elucidated as 3-O-beta-D-xylopyranosyl-(1-->2)-beta -D- fucopyranosyl - (1-->6) -beta -D-glucopyranosyl - 21-O-[(6S)-2 -trans-2-hydroxymethyl-6-methyl-6-O- [4-O-((6S)-2-trans-2-hydroxylmethy 6- methyl - 6- hydroxy)-2,7-octadienoyl-beta-D-quinovopy- -ranosyl]-2.7-octadienoyl}- acacic acid- 28 -O-beta-D-glucopranosyl-(1-->3)-[(alpha-L-arabinofuranosyl-(1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyrnosyl ester based on spectral and chemical evidences.
文摘A furostanol saponin was obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Its structure was determined as 3-O-β-D-glucopyranosyl-(25S)-22-O-methyl-5β-furost-1β, 3β, 5β, 22α; 26-pentaol-26-O-β-D-glucopyranoside (1) on the basis of chemical and spectroscopic evidences. The n-butanol fraction displayed marked inhibitory activity in vitro towards HeLa and HL-60 human tumor cell lines by MTT method.
基金support from the National Key R&D Program of China(2021YFA0716304)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB 0470301),the National Natural Science Foundation of China(U23A20623,21972153,and 52075524)+2 种基金Gansu Province Science and Technology Plan(20JR10RA060,22ZD6GA002,and 22ZD6GA025)Openning Project of State Key Laboratory of Solid Lubrication,LICP(LSL-2004)the Taishan Scholars Program.
文摘The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids.The rheological behavior of aqueous lubricating fluids with PPM has been characterized to confirm PPM’s function as a viscosity modifier.The tribological behavior of aqueous lubricating fluids with PPM has been investigated on SRV-V and MTM testing machines.It was found that PPM has excellent viscosity-increasing,lubricating,and anti-wear properties as an additive for aqueous,which can be attributed to the ability of PPM to form the protective film and boundary tribofilm generated from complex tribochemical reaction on rubbing surface.The obtained PPM with dual functions of anti-corrosion additives and viscosity index improver can play an important role in diverse lubrication regimes.
基金supported by National Natural Science Foundation of China(Nos20872060,20936002 and 31100080)the Fundamental Research Funds for Central University(No1082020502)
文摘Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis(RA).In a continuous research aiming at discovery of sinomenine derivates with better bioactivity,a cross-coupling reaction of sinomenine and 1,2-dihydroxybenzene catalyzed by a fungus Coriolus unicolor afforded an unique C-C cross-coupled compound 2,together with(S)-disinomenine and (R)-disinomenine.The structure of 2 was elucidated by MS and NMR spectroscopy.Compound 2 was further assayed for the inhibitory activity on IL-6 overproduction in SW982 cells and exhibited a much more potent activity on IL-6(96%inhibition) compared with those of(S)-disinomenine and sinomenine(17%and 12%inhibition,respectively).
文摘Eleven triazolyl substituted tetrahydrobenzofuran derivatives were synthesized in high yields as novel H+/K+- ATPase inhibitor via one-pot Cul-catalyzed three-component click reaction of azide, secondary amine and 3-bromopropyne under mild conditions in water. Their structures were characterized by NMR, IR, ESI-MS, ele- mental analysis and single-crystal X-ray diffraction analysis. Most of the target compounds exhibited better H+/K+- ATPase inhibitory activity than commercial omeprazole with IC50 values less than 15 gmol'L-~. The initial struc- ture-activity analysis suggested that the triazole substituted by cycloalkyl, aromatic ring or O-containing side-chain seemed to be beneficial for enhancing the activity.
文摘The surface force apparatus (SFA) plays a key role in research of nano-technology. A new SFA is introduced. With this apparatus, the theories about non-adhesion and adhesion contact were studied. The experiments showed the agreement between Hertz and non-adhesion contact. The JKR theory approximately accords with the experiment.
文摘7-epi-Taxane has been achieved efficiently in gram scale from natural taxane via inversion of the 7-hydroxyl group simply using Ag20 as catalyst and DMF as solvent. The catalyst could he quantitatively recovered by filtra- tion without loss of catalytic activity. This condition is also applicable to the direct epimerization of taxane derivatives (e.g., docetaxel and paclitaxel) to 7-epi-taxane derivatives (e.g., 7-epi-docetaxel and 7-epi-paclitaxel). Furthermore, 33 ester derivatives of 7-epi-taxane with different amino acid moieties at the position of C-13 were successfully synthesized via esterification without protecting C-7-OH. Bioassay results revealed that compounds 13 and 18 have good selectivity against prostatic cancer cell line DU145, with ICs0 value as low as 15.9 nmol/L for 18.
基金This work was supported by the National Natural Science Foundation of China(51675097,U1632128,and 51775105)the Natural Science Foundation of Shanghai(17ZR1400700)the Fundamental Research Funds for the Central Universities ad DHU Distinguished Young Professor Program.
文摘The nanofriction properties of hexagonal boron nitride(h-BN)are vital for its application as a substrate for graphene devices and solid lubricants in micro-and nano-electromechanical devices.In this work,the nanofriction characteristics of h-BN on Si/SiO_(2) substrates with a bias voltage are explored using a conductive atomic force microscopy(AFM)tip sliding on the h-BN surface under different substrate bias voltages.The results show that the nanofriction on h-BN increases with an increase in the applied bias difference(V_(t–s))between the conductive tip and the substrate.The nanofriction under negative V_(t–s) is larger than that under positive V_(t–s).The variation in nanofriction is relevant to the electrostatic interaction caused by the charging effect.The electrostatic force between opposite charges localized on the conductive tip and at the SiO2/Si interface increases with an increase in V_(t–s).Owing to the characteristics of p-type silicon,a positive V_(t–s) will first cause depletion of majority carriers,which results in a difference of nanofriction under positive and negative V_(t–s).Our findings provide an approach for manipulating the nanofriction of 2D insulating material surfaces through an applied electric field,and are helpful for designing a substrate for graphene devices.