In situ calibrated angle between the quantization axis and the propagating direction of the light field for trapping neutral atoms

The recently developed magic-intensity trapping technique of neutral atoms efficiently mitigates the detrimental effect of light shifts on atomic qubits and substantially enhances the coherence time. This technique relies on applying a bias magnetic field precisely parallel to the wave vector of a circularly polarized trapping laser field. However, due to the presence of the vector light shift experienced by the trapped atoms, it is challenging to precisely define a parallel magnetic field, especially at a low bias magnetic field strength, for the magic-intensity trapping of85Rb qubits. In this work, we present a method to calibrate the angle between the bias magnetic field and the trapping laser field with the compensating magnetic fields in the other two directions orthogonal to the bias magnetic field direction. Experimentally, with a constantdepth trap and a fixed bias magnetic field, we measure the respective resonant frequencies of the atomic qubits in a linearly polarized trap and a circularly polarized one via the conventional microwave Rabi spectra with different compensating magnetic fields and obtain the corresponding total magnetic fields via the respective resonant frequencies using the Breit–Rabi formula. With known total magnetic fields, the angle is a function of the other two compensating magnetic fields.Finally, the projection value of the angle on either of the directions orthogonal to the bias magnetic field direction can be reduced to 0(4)° by applying specific compensating magnetic fields. The measurement error is mainly attributed to the fluctuation of atomic temperature. Moreover, it also demonstrates that, even for a small angle, the effect is strong enough to cause large decoherence of Rabi oscillation in a magic-intensity trap. Although the compensation method demonstrated here is explored for the magic-intensity trapping technique, it can be applied to a variety of similar precision measurements with trapped neutral atoms.

Minimally invasive treatment of hepatic hemangioma by transcatheter arterial embolization combined with microwave ablation:A case report

BACKGROUND Hepatic hemangioma is the most common benign tumor of the liver.However,patients with large hemangiomas that cause compression symptoms or that are at risk of rupture may need further intervention.It is necessary to explore additional minimally invasive and personalized treatment options for hemangiomas.CASE SUMMARY A 47-year-old woman was diagnosed with a right hepatic hemangioma for more than 10 years.Abdominal contrast-enhanced computed tomography(CT)and contrast-enhanced ultrasound revealed that there was a large hemangioma in the right liver,with a size of approximately 95 mm×97 mm×117 mm.Due to the patient's refusal of surgical treatment,hepatic artery embolization was performed in the first stage.After 25 d of liver protection treatment,the liver function indexes decreased to normal levels.Then,ultrasound-guided microwave ablation of the giant hepatic hemangioma was performed.Ten days after the treatment,hepatobiliary ultrasonography showed that the hemangioma of the right liver was smaller than the previous size(the volume was reduced by approximately 30%).Then the patient was discharged from the hospital.One year after discharge,CT showed that the hepatic hemangioma had shrunk by about 80%CONCLUSION Transcatheter arterial embolization combined with microwave ablation is a safe and effective minimally invasive treatment for hepatic hemangioma.

Rare recurrent gallstone ileus: A case report

BACKGROUND The management of recurrent gallstone ileus(GSI)is unsatisfactory,and there is no consensus on how to reduce the incidence of recurrent GSI.CASE SUMMARY A 79-year-old man presented to the Emergency Department of our hospital complaining of abdominal pain.An abdominal computed tomography(CT)scan revealed cholecystolithiasis,intrahepatic bile duct dilatation,gas accumulation,small intestinal obstruction,and circular high-density shadow in the intestinal cavity.Emergency surgery revealed that the small intestine had extensive adhesions,unclear gallbladder exposure,obvious adhesions,and difficult separation.The obstruction was located 70 cm between the ileum and the ileocecum,which was incarcerated by gallstones,and a simple enterolithotomy was carried out.On the third day after the operation,he had passed gas and defecated and had begun a liquid diet.On the fifth day after the operation,he suddenly experienced abdominal distension and discomfort.Emergency CT examination revealed recurrent GSI,and the diameter of the stone was approximately 2.0 cm(consistent with the shape of cholecystolithiasis on the abdominal CT scan before the first operation).The patient’s symptoms were not significantly relieved after conservative treatment.On the ninth day after the operation,emergency enterolithotomy was performed again along the original surgical incision.On the twentieth day after the second operation,the patient fully recovered and was discharged from the hospital.CONCLUSION We believe that a thorough examination of the bowel and gallbladder for gallstones based on preoperative imaging during surgery and removal of them as far as possible on the premise of ensuring the safety of patients are an effective strategy to reduce the recurrence of GSI.

High-Fidelity Manipulation of the Quantized Motion of a Single Atom via Stern-Gerlach Splitting

We demonstrate high-fidelity manipulation of the quantized motion of a single87Rb atom in an optical tweezer via microwave couplings induced by Stern–Gerlach splitting. The Stern–Gerlach splitting is mediated by polarization gradient of a strongly focused tweezer beam that functions as fictitious magnetic field gradient. The spatial splitting removes the orthogonality of the atomic spatial wavefunctions, thus enables the microwave couplings between the motional states. We obtain coherent Rabi oscillations for up to third-order sideband transitions, in which a high fidelity of larger than 0.99 is obtained for the spin-flip transition on the first order sideband after subtraction of the state preparation and detection error. The Stern–Gerlach splitting is measured at a precision of better than 0.05 nm. This work paves the way for quantum engineering of motional states of single atoms, and may have wide applications in few body physics and ultracold chemistry.

Signature Based on Six Autophagy-related Genes to Predict Prognosis of Head and Neck Squamous Cell Carcinoma

Objective The present study aimed to develop an autophagy-related gene prognostic prediction model to provide survival risk prediction for head and neck squamous cell carcinoma(HNSCC)patients.Methods The K-mean cluster analysis was performed on HNSCC samples based on the expression values of 210 autophagy-related genes for candidate signature gene selection.LASSO Cox regression analysis was generated using the potential genes and the risk score was calculated from the prognosis model.The risk score was processed as an independent prognostic indicator to construct the nomogram model.The immune status including immune cell infiltration ratio and checkpoints of patients with HNSCC in high-and low-risk groups was also explored.Results LASSO Cox regression analysis was performed on the selected autophagy-related genes.According to the lambda value corresponding to the number of different genes in the LASSO Cox analysis,six genes(GABARAPL2,SAR1A,ST13,GAPDH,FADD and LAMP1)were finally chosen.The risk score based on the genes was generated,which was an independent prognostic marker for HNSCC.The prognostic prediction model(nomogram)was further optimized by the independent prognostic factors(risk score),which can better predict the prognosis and survival of patients.With the risk score and prognosis model,eight types of immune cells and six key immune checkpoints(CTLA4,PD1,IDO1,TDO2,LAG3,TIGIT)displayed expression specificity.Conclusion This study identified several potential prognostic biomarkers and established an autophagy-related prognostic prediction model for HNSCC,which provides a valuable reference for future clinical research.

Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

Photodynamic therapy(PDT)is an effective and promising cancer treatment.PDT directly generates reactive oxygen species(ROS)through photochemical reactions.This oxygen-dependent exogenous ROS has anti-cancer stem cell(CSC)effect.In addition,PDT may also increase ROS production by altering metabolism,endoplasmic reticulum stress,or potential of mitochondrial membrane.It is known that the half-life of ROS in PDT is short,with high reactivity and limited diffusion distance.Therefore,the main targeting position of PDT is often the subcellular localization of photosensitizers,which is helpful for us to explain how PDT affects CSC characteristics,including differentiation,selfrenewal,apoptosis,autophagy,and immunogenicity.Broadly speaking,excess ROS will damage the redox system and cause oxidative damage to molecules such as DNA,change mitochondrial permeability,activate unfolded protein response,autophagy,and CSC resting state.Therefore,understanding the molecular mechanism by which ROS affect CSCs is beneficial to improve the efficiency of PDT and prevent tumor recurrence and metastasis.In this article,we review the effects of two types of photochemical reactions on PDT,the metabolic processes,and the biological effects of ROS in different subcellular locations on CSCs.

Interference properties of a trapped atom interferometer in two asymmetric optical dipole traps

We investigate interference properties of a trapped atom interferometer where two symmetric optical dipole traps(ODTs)act as the atomic wave-packets splitter and combiner with internal state labelling.After the preparation of initial superposition states,the atomic wave-packet is adiabatically split and moves into two spatially separate asymmetric ODTs.The atomic wave-packets in two ODTs are then adiabatically recombined after a duration of free evolving in traps,completing the interference cycle of this atom interferometer.We show that the interferogram exhibits a series of periodic revivals in interference visibility.Furthermore,the revival period decreases as the asymmetry of two dipole potentials increases.By introducing an echo sequence to the interferometer,we show that while the echo effect is not influenced by the asymmetry of the two ODTs,the onset of periodic revivals changes by the echo sequence.Our study provides an effective method to cancel or compensate the phase shift caused by position and time correlated force.

Intestinal gangrene secondary to congenital transmesenteric hernia in a child misdiagnosed with gastrointestinal bleeding: A case report

BACKGROUND Congenital transmesenteric hernia in children is a rare and potentially fatal form of internal abdominal hernia,and no specific clinical symptoms can be observed preoperatively.Therefore,this condition is not widely known among clinicians,and it is easily misdiagnosed,resulting in disastrous effects.CASE SUMMARY This report presents the case of a 13-year-old boy with a chief complaint of abdominal pain and vomiting and a history of duodenal ulcer.The patient was misdiagnosed with gastrointestinal bleeding and treated conservatively at first.Then,the patient’s symptoms were aggravated and he presented in a shock-like state.Computed tomography revealed a suspected internal hernia,extensive small intestinal obstruction,and massive effusion in the abdominal and pelvic cavity.Intraoperative exploration found a small mesenteric defect approximately 3.5 cm in diameter near the ileocecal valve,and there was about 1.8 m of herniated small intestine that was treated by resection and anastomosis.The patient recovered well and was followed for more than 5 years without developing short bowel syndrome.CONCLUSION In this report,we review the pathogenesis,presentation,diagnosis,and treatment of congenital transmesenteric hernia in children.

Adult duodenal intussusception with horizontal adenoma: A rare case report

BACKGROUND Adult duodenal intussusception rarely occurs,and the majority of duodenal adenomas are located in the descending part of the duodenum.Therefore,adenomas in the horizontal part of the duodenum presenting as duodenal intussusception in adults are extremely rare.CASE SUMMARY A 36-year-old man complained of abdominal pain for 13 d.Blood analysis showed anemia.Magnetic resonance cholangiopancreatography and computed tomography revealed a tumor in the horizontal part of the duodenum as the main finding,leading to duodeno-duodenal intussusception.No obvious abnormalities were found on endoscopy or upper gastrointestinal radiography.He was diagnosed with duodenal intussusception secondary to duodenal adenoma.Laparotomy showed duodeno-duodenal intussusception and a tumor in the horizontal part of the duodenum near the ascending part.Postoperative pathology revealed tubular-villous adenoma with low-grade glandular intraepithelial neoplasia(local high-grade intraepithelial neoplasia).He was discharged without complications.CONCLUSION This case highlights that rational use of computed tomography,magnetic resonance cholangiopancreatography,endoscopy and upper gastrointestinal radiography for preoperative diagnosis and timely surgery is an effective strategy for the treatment of adult duodenal intussusception with duodenal masses.

Dual-ion pre-inserted Mo glycerate template for constructing NiMo-OS core–shell structure with boosting performance in zinc ions hybrid supercapacitors

Zinc ion hybrid supercapacitors(ZHS)have received much attention due to the enhanced potential window range and high specific capacity.However,the appropriate positive materials with high electrochemical performance are still a challenge.Herein,NH_(4)^(+)and glycerate anions pre-inserted Mo glycerate(N-MoG)spheres are synthesized and serve as the template to form NH_(4)^(+)intercalated Ni_(3)S_(2)/Ni_(3)O_(2)(OH)_(4)@MoS_(2)core–shell nanoflower(N-NiMo-OS)in-situ grown on nickel foam(NF)(N-NiMo-OS/NF)by sulfurization treatment.Compared with the product using traditional MoG as a template,N-NiMo-OS/NF inheriting a larger core structure from N-MoG delivers enhanced space for ions transport and volume expansion during the energy storage process,together with the synergistic effects of multi-components and the heterostructure,the as-prepared N-NiMo-OS/NF nanoflower exhibits excellent performance for the battery-type hybrid supercapacitors(BHS)and ZHS devices.Notably,the ZHS device delivers superior electrochemical performance to the BHS device,such as a higher specific capacity of 327.5 mAh·g^(−1)at 1 A·g^(−1),a preeminent energy density of 610.6 Wh·kg^(−1)at 1710 W·kg^(−1),long cycle life.The in-situ Raman,ex-situ X-ray photoelectron spectroscopy(XPS),theoretical calculation demonstrate the extra Zn^(2+)insertion/extraction storage mechanism provides enhanced electrochemical performance for ZHS device.Therefore,the dual-ion pre-inserted strategy can be extended for other advanced electrode materials in energy storage fields.

Relief Effect of Bevacizumab on Severe Edema Induced by Re-irradiation in Brain Tumor Patients

INTRODUCTION Brain edema is a serious clinical event and could cause various neurological symptoms such as dizziness and headache.Drugs frequently used to relieve brain edema include steroid,dehydrant （e.g.,mannitol）,and diuretics.But the effects of these drugs were limited in patients with severe edema.Bevacizumab has been applied in the treatment of cerebral radiation necrosis. Case studies have reported on the application of bevacizumab in the treatment of severe brain edema. In the present study,we describe significant effects of bevacizumab on severe brain edema in patients with re-irradiation.

Effects of ferrosilicon alloy,Si content of steel,and slag basicity on compositions of inclusions during ladle furnace refining of Al-killed steel

To obtain solid Al2O3 or MgO·Al2O3 inclusions in ladle furnace(LF)refining process and achieve ultra-low total oxygen content in steel through subsequent Ruhrstahl Heraeus degassing,the effects of ferrosilicon alloy,Si content of steel,and slag basicity on the compositions of inclusions during LF refining were investigated in Al-killed steel.Al2O3 inclusions could be transformed into CaO-Al2O3-MgO-CaS inclusions after adding ferrosilicon alloy in the LF refining process as this alloy contains some CaSi alloy impurities.The addition of all ferrosilicon alloys required for the steel in the tapping process could eliminate the influence of Ca in ferrosilicon alloy on the compositions of inclusions.Si in liquid steel had a significant influence on the compositions of inclusions during LF refining when CaO-Al2O3-SiO2-MgO slag with high basicity of 7.0 was used.This was because[Ca]produced by the reaction of CaO and[Al]could be consumed more readily by SiO2 in Si-free steel than in Si-containing steel,which was confirmed by the difference of total calcium content between Si-free and Si-containing steels.As a result,Al2O3 and MgO·Al2O3 inclusions were retained in Si-free steel,whereas calcium aluminate inclusions were found in Si-containing steel.For CaO-Al2O3-SiO2-MgO slag with low basicity of 2.8,Al2O3 and MgO·Al2O3 inclusions were obtained after LF refining in Si-containing steel when all ferrosilicon alloys required for the steel were added in the tapping process.This was because the reaction of CaO and[Al]was weak,and residual[Ca]in the steel could be rapidly consumed by SiO2 in low-basicity slag owing to the low activity of CaO and high activity of SiO2,leading to a low total calcium content of 0.0003%in Si-containing steel.

Glycine-conjugated porphyrin fluorescent probe with iRGD for live cell imaging

A porphyrin modified by glycine has been synthesized and developed as a near-infrared（NIR）fluorescence probe to detect tumor.Porphyrins＇ longwavelength emission at ~650 nm can efficiently avoid the spectral crosstalk with Spontaneous fluorescence in the visible light region.A disulfide-based cyclic RGD peptide named iRGD c（CRGDKGPDC）,a tumor homing peptide,harbors a cryptic C-end Rule（CendR） motif that is responsible for neuropilin-1（NRP-1） binding and for triggering extravasation and tumor penetration of the peptide to improve the imaging sensitivity and therapeutic efficacy.We used N hydroxy succinimide as an activator to introduce the glycine methyl ester to detect tumor.We got a porphyrin modified by glycine.The affinity between probe and tumor cell entered GLC-82 cells（human glandular lung cancer cell line） can be observed by Confocal Microscope.The toxicity of probe has been identified by MTT Assay.The summary has been gotten that the porphyrins were nontoxic to GLC-82 cells and glycine modified porphyrin has a good affinity with GLC-82 cells under the iRGD function by our experiment.