To the Editor:Coronary heart disease(CHD)and depression are common in patients worldwide and have a high comorbidity rate.Researches on depression have shown that it has been linked with long-term risk for CHD.[1]The ...To the Editor:Coronary heart disease(CHD)and depression are common in patients worldwide and have a high comorbidity rate.Researches on depression have shown that it has been linked with long-term risk for CHD.[1]The incidence and mortality of depression with CHD were higher,and the prognosis was worse.[2]The association between CHD and depression is well established and is suggested to be bidirectional.[3]Therefore,to provide possible conditions for the study of depression with CHD in the future,establishing a reliable animal model of depression with CHD is necessary.Chronic unpredictable mild stress(CUMS)is the most widely used to establish an animal model of depression for the past few years.Feeding a high-fat diet(HFD)to rats is a widely used method for establishing a model for atherosclerosis and CHD.Research reported that female cynomolgus monkeys that were housed in single cages and consumed an atherogenic diet could develop depression combined with CHD model.[4]Another paper reported that CUMS combined with HFD in rats was similar to the clinical manifestation of vascular depression in humans.[5]The former demonstrated that housing in single cages and feeding an atherogenic diet in monkeys could establish a depression combined with CHD model,the latter demonstrated that CUMS combined with HFD in rats was similar to vascular depression.It remains unclear whether CUMS combined with HFD in rats could establish a complex rat model of depression with CHD.Consequently,the aim of this study was to explore whether CUMS combined with HFD in rats could establish a representative,reliable rat model of depression with CHD and to provide possible conditions for an in-depth study of depression with CHD.展开更多
基金The study was approved by the grants from the National Natural Science Foundation of China(No.81560730)the Training Project for Young and Middle-aged Chinese Medicine Leaders in Yunnan Province.
文摘To the Editor:Coronary heart disease(CHD)and depression are common in patients worldwide and have a high comorbidity rate.Researches on depression have shown that it has been linked with long-term risk for CHD.[1]The incidence and mortality of depression with CHD were higher,and the prognosis was worse.[2]The association between CHD and depression is well established and is suggested to be bidirectional.[3]Therefore,to provide possible conditions for the study of depression with CHD in the future,establishing a reliable animal model of depression with CHD is necessary.Chronic unpredictable mild stress(CUMS)is the most widely used to establish an animal model of depression for the past few years.Feeding a high-fat diet(HFD)to rats is a widely used method for establishing a model for atherosclerosis and CHD.Research reported that female cynomolgus monkeys that were housed in single cages and consumed an atherogenic diet could develop depression combined with CHD model.[4]Another paper reported that CUMS combined with HFD in rats was similar to the clinical manifestation of vascular depression in humans.[5]The former demonstrated that housing in single cages and feeding an atherogenic diet in monkeys could establish a depression combined with CHD model,the latter demonstrated that CUMS combined with HFD in rats was similar to vascular depression.It remains unclear whether CUMS combined with HFD in rats could establish a complex rat model of depression with CHD.Consequently,the aim of this study was to explore whether CUMS combined with HFD in rats could establish a representative,reliable rat model of depression with CHD and to provide possible conditions for an in-depth study of depression with CHD.
