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Long-Term Prognosis and Predictive Risk Factors for Polyvascular Disease in Patients with Peripheral Arterial Disease
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作者 kuniki nakashima Hisao Kumakura +5 位作者 Ryuichi Funada Yae Matsuo Kimimasa Sakata Akiko Ichikawa Toshiya Iwasaki Shuichi Ichikawa 《World Journal of Cardiovascular Diseases》 2022年第1期50-64,共15页
<strong>Background: </strong><span style="white-space:normal;font-family:;" "="">The aim of </span><span style="white-space:normal;font-family:;" "=&q... <strong>Background: </strong><span style="white-space:normal;font-family:;" "="">The aim of </span><span style="white-space:normal;font-family:;" "="">the </span><span style="white-space:normal;font-family:;" "="">current study was to assess fifteen-year life expectancy, </span><span style="white-space:normal;font-family:;" "="">cardiovascular events</span><span style="white-space:normal;font-family:;" "="">,</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "="">fate of the limb, and risk factors with or</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "="">without polyvascular disease in patients with Peripheral Arterial Disease</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "="">(PAD). <b>Methods: </b>We conducted a prospective cohort study in 1019 PAD patients. The endpoints were Cardiovascular or Cerebrovascular Death (CCVD), All-Cause Death (A</span><span style="white-space:normal;font-family:;" "="">CD), Major Adverse Cardiovascular Events (MACE), and Cardiovascular and/or Limb Events (CVLE). <b>Results: </b>The patients who died were 539 (52.9%) during follow-up periods. The rate of CCVD was 50.5% (n = 272). In multiple regression analysis, the number of affected arteries had correlations with estimated Glomerular Filtration Rate (eGFR), HDL-cholesterol, Ankle Brachial Pressure Index (ABI), and diabetes (p < 0.05). In multiple logistic analysis, PAD with Cerebrovascular Disease (CVD) was correlated with older age, ABI, eGFR, and atrial fibrillation (p < 0.05);PAD with Coronary Heart Disease (CHD) was correlated with younger age, eGFR, HDL-cholesterol, LDL-</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "="">cholesterol, and diabetes (p < 0.05);and triple vascular disease (PAD with</span><span style="white-space:normal;font-family:;" "=""> CVD and CHD) was correlated with ABI, eGFR, HDL-cholesterol, and diabetes (p < 0.05).</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "="">The number of affected arteries had significant correlations with</span><span style="white-space:normal;font-family:;" "=""> CCVD, ACD, MACE, and CVLE</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "="">(p</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "=""><</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "="">0.05).</span><span style="white-space:normal;font-family:;" "=""> </span><span style="white-space:normal;font-family:;" "="">In Cox multivariate analyses, age, Critical Limb Ischemia (CLI), eGFR, albumin, C-Reactive Protein (CRP), Body Mass Index (BMI), CVD, and CHD were related to CCVD (p < 0.05);age, albumin, eGFR, CRP, BMI, CLI, and CVD were associated with ACD (p < 0.05);age, albumin, eGFR, CRP, CLI, CHD, and diabetes were associated with MACE (p < 0.05);age, ABI, albumin, eGFR, CRP, CLI, CHD, and diabetes were related to CVLE (p < 0.05). Statins improved all outcomes (p < 0.05). <b>Conclusions:</b> Polyvascular disease was independently associated with fifteen-year mortality, cardiovascular events, and </span><span style="white-space:normal;font-family:;" "="">the </span><span style="white-space:normal;font-family:;" "="">fate of the limb with diverse risk factors in </span><span style="white-space:normal;font-family:;" "="">PAD patients.</span> 展开更多
关键词 Polyvascular Disease Cerebral Infarction Coronary Heart Disease Fate of Leg Peripheral Arterial Disease
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