We have previously cloned human papillomavirus type 82 (HPV- 82) from a vaginal intraepithelial neoplasia, but it is not known whether HPV- 82 can induce a cutaneous lesion. A large erosive nodule developed on the scr...We have previously cloned human papillomavirus type 82 (HPV- 82) from a vaginal intraepithelial neoplasia, but it is not known whether HPV- 82 can induce a cutaneous lesion. A large erosive nodule developed on the scrotum of a 50- year- old Japanese patient. Histopathologically, the lesion was composed of two distinct parts; one part showing changes characteristic of Bowen’ s disease in the epidermis, and the other showing elongated rete ridges and proliferation of atypical basaloid cells in the dermis. These parts were partially connected, giving the diagnosis of Bowen’ s carcinoma. Immunohistochemically, HPV capsid antigen was detected only in the nuclei of a few cells on the upper part of the epidermis. HPV- 82 was identified in the lesion by blot hybridization and viral DNA was demonstrated in the lesion by in situ hybridization. HPV- 82 has tropism for both the skin and the genital region.展开更多
文摘We have previously cloned human papillomavirus type 82 (HPV- 82) from a vaginal intraepithelial neoplasia, but it is not known whether HPV- 82 can induce a cutaneous lesion. A large erosive nodule developed on the scrotum of a 50- year- old Japanese patient. Histopathologically, the lesion was composed of two distinct parts; one part showing changes characteristic of Bowen’ s disease in the epidermis, and the other showing elongated rete ridges and proliferation of atypical basaloid cells in the dermis. These parts were partially connected, giving the diagnosis of Bowen’ s carcinoma. Immunohistochemically, HPV capsid antigen was detected only in the nuclei of a few cells on the upper part of the epidermis. HPV- 82 was identified in the lesion by blot hybridization and viral DNA was demonstrated in the lesion by in situ hybridization. HPV- 82 has tropism for both the skin and the genital region.
