In order to improve the energy efficiency(EE) in cognitive radio(CR), a joint optimal energy-efficient cooperative spectrum sensing(CSS) and transmission in multi-channel CR is proposed in this paper. EE is described ...In order to improve the energy efficiency(EE) in cognitive radio(CR), a joint optimal energy-efficient cooperative spectrum sensing(CSS) and transmission in multi-channel CR is proposed in this paper. EE is described as a tradeoff between the throughput and the entirely consumed power. A joint optimization problem is formulated to maximize EE by jointly optimizing local sensing time, number of cooperative sensing secondary users(SU), transmission bandwidth and power. A combined optimization algorithm of bi-level optimization, Polyblock optimization and Dinkelbach's optimization is proposed to solve the proposed non-convex optimization problem effectively. The simulation results show that, compared with throughput maximization model(TMM), the energy efficiency maximization model(EEMM) improves EE of the CR system and limits the excessive power consumption effectively.展开更多
As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs(lncRNAs),N6-methyladenosine(m^(6)A)RNA methylation has been shown to participate in essential biological processes.Recent studies have ...As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs(lncRNAs),N6-methyladenosine(m^(6)A)RNA methylation has been shown to participate in essential biological processes.Recent studies have revealed the distinct patterns of m^(6)A methylome across human tissues,and a major challenge remains in elucidating the tissue-specific presence and circuitry of m^(6)A methylation.We present here a comprehensive online platform,m^(6)A-TSHub,for unveiling the context-specific m^(6)A methylation and genetic mutations that potentially regulate m^(6)A epigenetic mark.m^(6)A-TSHub consists of four core components,including(1)m^(6)A-TSDB,a comprehensive database of 184,554 functionally annotated m^(6)A sites derived from 23 human tissues and 499,369 m^(6)A sites from 25 tumor conditions,respectively;(2)m^(6)A-TSFinder,a web server for high-accuracy prediction of m^(6)A methylation sites within a specific tissue from RNA sequences,which was constructed using multi-instance deep neural networks with gated attention;(3)m^(6)ATSVar,a web server for assessing the impact of genetic variants on tissue-specific m^(6)A RNA modifications;and(4)m^(6)A-CAVar,a database of 587,983 The Cancer Genome Atlas(TCGA)cancer mutations(derived from 27 cancer types)that were predicted to affect m^(6)A modifications in the primary tissue of cancers.The database should make a useful resource for studying the m^(6)A methylome and the genetic factors of epitranscriptome disturbance in a specific tissue(or cancer type).m^(6)A-TSHub is accessible at www.xjtlu.edu.cn/biologicalsciences/m^(6)ats.展开更多
基金supported by the National Natural Science Foundations of China under Grant Nos. 61301105, 61401288 and 61601221the Natural Science Foundations of Jiangsu Province under Grant No. BK20140828+1 种基金the China Postdoctoral Science Foundations under Grant Nos. 2015M581791 and 2015M580425the Fundamental Research Funds for the Central Universities under Grant No. DUT16RC(3)045
文摘In order to improve the energy efficiency(EE) in cognitive radio(CR), a joint optimal energy-efficient cooperative spectrum sensing(CSS) and transmission in multi-channel CR is proposed in this paper. EE is described as a tradeoff between the throughput and the entirely consumed power. A joint optimization problem is formulated to maximize EE by jointly optimizing local sensing time, number of cooperative sensing secondary users(SU), transmission bandwidth and power. A combined optimization algorithm of bi-level optimization, Polyblock optimization and Dinkelbach's optimization is proposed to solve the proposed non-convex optimization problem effectively. The simulation results show that, compared with throughput maximization model(TMM), the energy efficiency maximization model(EEMM) improves EE of the CR system and limits the excessive power consumption effectively.
基金supported by the National Natural Science Foundation of China(Grant Nos.32100519 and 31671373)the Scientific Research Foundation for Advanced Talents of Fujian Medical University(Grant No.XRCZX2021019)the XJTLU Key Program Special Fund(Grant Nos.KSF-T-01,KSF-E-51,and KSF-P-02),China.
文摘As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs(lncRNAs),N6-methyladenosine(m^(6)A)RNA methylation has been shown to participate in essential biological processes.Recent studies have revealed the distinct patterns of m^(6)A methylome across human tissues,and a major challenge remains in elucidating the tissue-specific presence and circuitry of m^(6)A methylation.We present here a comprehensive online platform,m^(6)A-TSHub,for unveiling the context-specific m^(6)A methylation and genetic mutations that potentially regulate m^(6)A epigenetic mark.m^(6)A-TSHub consists of four core components,including(1)m^(6)A-TSDB,a comprehensive database of 184,554 functionally annotated m^(6)A sites derived from 23 human tissues and 499,369 m^(6)A sites from 25 tumor conditions,respectively;(2)m^(6)A-TSFinder,a web server for high-accuracy prediction of m^(6)A methylation sites within a specific tissue from RNA sequences,which was constructed using multi-instance deep neural networks with gated attention;(3)m^(6)ATSVar,a web server for assessing the impact of genetic variants on tissue-specific m^(6)A RNA modifications;and(4)m^(6)A-CAVar,a database of 587,983 The Cancer Genome Atlas(TCGA)cancer mutations(derived from 27 cancer types)that were predicted to affect m^(6)A modifications in the primary tissue of cancers.The database should make a useful resource for studying the m^(6)A methylome and the genetic factors of epitranscriptome disturbance in a specific tissue(or cancer type).m^(6)A-TSHub is accessible at www.xjtlu.edu.cn/biologicalsciences/m^(6)ats.