A 42-year-old man presented with painful erythema with pustules and multiple small ulcers on the shins. He had suffered from ulcerative colitis(UC) and received oral glucocorticosteroid and salicylazosulfapyridine the...A 42-year-old man presented with painful erythema with pustules and multiple small ulcers on the shins. He had suffered from ulcerative colitis(UC) and received oral glucocorticosteroid and salicylazosulfapyridine therapies for 7 years. Biopsy of the lesion demonstrated mixed cellular infiltrates with dominant neutrophils. The patient was diagnosed with pyoderma gangrenosum(PG) and underwent leukocytapheresis(LCAP), an extracorporeal leucocyte removal therapy, once a week for 5 weeks without changing the doses of the oral medications. The skin lesions as well as clinical signs of UC rapidly improved after LCAP, and no recurrence was seen during a follow-up period. There were no major complications during LCAP. LCAP will provide an effective and safe tool for the treatment of PG.展开更多
Background: We have previously reported that type II collagen deposition in overlying dermo-epidermal junction (DEJ) of pilomatricoma is mediated by bone morphogenetic protein 2/4 (BMP 2/4) expressed by shadow cells (...Background: We have previously reported that type II collagen deposition in overlying dermo-epidermal junction (DEJ) of pilomatricoma is mediated by bone morphogenetic protein 2/4 (BMP 2/4) expressed by shadow cells (SCs) of pilomatricoma. Objective: This time, we studied the expression of type II collagen and BMP in a large number of cases of pilomatricoma and extended our study to cutaneous mixed tumor (CMT). Results: WefoundtypeIIcollagendepositionintheoverlyingDEJ(16of 50 cases) and in the SCs (19/50) of pilomatricoma. The number of case of type II collagen deposition in DEJ(DEJ+ )and in SCs (SC+ ) of pilomatricoma correlated to the chronological stage of pilomatricoma. We also found type II collagen deposition in overlying DEJ (two of 11) and in the stromal chondroid tissue (four of 11) of CMT. BMP 2 was expressed in most cases of pilomatricoma (37/50) and CMT (seven of 11). Conclusions: The expression of type II collagen in pilomatricoma is dependent upon the chronological stage of pilomatricoma. Type II collagen expression in the overlying DEJ and chondroid matrix in CMT may be induced by BMP via the same mechanism as in pilomatricoma.展开更多
We describe a patient with eosinophilic pustular folliculitis wh o partially responded to oral indomethacin, but intermittently experienced neweo sinophilic pustular folliculitis lesions. Treatment with tacrolimus oin...We describe a patient with eosinophilic pustular folliculitis wh o partially responded to oral indomethacin, but intermittently experienced neweo sinophilic pustular folliculitis lesions. Treatment with tacrolimus ointment 0.1 % resulted in the rapid improvement of each recurred lesion and allowed withdr awal of indomethacin. To our knowledge, this is the first report of the use of t opical tacrolimus in the treatment of eosinophilic pustular folliculitis. Abstract: Primary carcinoid tumor of the skin Cokonis C.-D./Green J.J./Manders S.M. - J. AM. ACAD. DERMATOL. 2004, 51/5 SUPPL. (S74-S76) Abstract:We describe the case of a 64- year-old man with a cutaneous carcin oid tumo r. Clinical investigation and diagnostic studies failed to reveal an internal pr imary tumor. Five cases of primary cutaneous carcinoid tumor have been reported in the literature. Interestingly, our patient had coexisting lichen planus, whic h has been reported previously in association with carcinoid.展开更多
文摘A 42-year-old man presented with painful erythema with pustules and multiple small ulcers on the shins. He had suffered from ulcerative colitis(UC) and received oral glucocorticosteroid and salicylazosulfapyridine therapies for 7 years. Biopsy of the lesion demonstrated mixed cellular infiltrates with dominant neutrophils. The patient was diagnosed with pyoderma gangrenosum(PG) and underwent leukocytapheresis(LCAP), an extracorporeal leucocyte removal therapy, once a week for 5 weeks without changing the doses of the oral medications. The skin lesions as well as clinical signs of UC rapidly improved after LCAP, and no recurrence was seen during a follow-up period. There were no major complications during LCAP. LCAP will provide an effective and safe tool for the treatment of PG.
文摘Background: We have previously reported that type II collagen deposition in overlying dermo-epidermal junction (DEJ) of pilomatricoma is mediated by bone morphogenetic protein 2/4 (BMP 2/4) expressed by shadow cells (SCs) of pilomatricoma. Objective: This time, we studied the expression of type II collagen and BMP in a large number of cases of pilomatricoma and extended our study to cutaneous mixed tumor (CMT). Results: WefoundtypeIIcollagendepositionintheoverlyingDEJ(16of 50 cases) and in the SCs (19/50) of pilomatricoma. The number of case of type II collagen deposition in DEJ(DEJ+ )and in SCs (SC+ ) of pilomatricoma correlated to the chronological stage of pilomatricoma. We also found type II collagen deposition in overlying DEJ (two of 11) and in the stromal chondroid tissue (four of 11) of CMT. BMP 2 was expressed in most cases of pilomatricoma (37/50) and CMT (seven of 11). Conclusions: The expression of type II collagen in pilomatricoma is dependent upon the chronological stage of pilomatricoma. Type II collagen expression in the overlying DEJ and chondroid matrix in CMT may be induced by BMP via the same mechanism as in pilomatricoma.
文摘We describe a patient with eosinophilic pustular folliculitis wh o partially responded to oral indomethacin, but intermittently experienced neweo sinophilic pustular folliculitis lesions. Treatment with tacrolimus ointment 0.1 % resulted in the rapid improvement of each recurred lesion and allowed withdr awal of indomethacin. To our knowledge, this is the first report of the use of t opical tacrolimus in the treatment of eosinophilic pustular folliculitis. Abstract: Primary carcinoid tumor of the skin Cokonis C.-D./Green J.J./Manders S.M. - J. AM. ACAD. DERMATOL. 2004, 51/5 SUPPL. (S74-S76) Abstract:We describe the case of a 64- year-old man with a cutaneous carcin oid tumo r. Clinical investigation and diagnostic studies failed to reveal an internal pr imary tumor. Five cases of primary cutaneous carcinoid tumor have been reported in the literature. Interestingly, our patient had coexisting lichen planus, whic h has been reported previously in association with carcinoid.
