Near-infrared spectroscopy has been used for measurement of changes in cerebr al Hb concentrations in infants to study cerebral oxygenation and hemodynamics. In this study, measurements by time-resolved spectroscopy (...Near-infrared spectroscopy has been used for measurement of changes in cerebr al Hb concentrations in infants to study cerebral oxygenation and hemodynamics. In this study, measurements by time-resolved spectroscopy (TRS) were performed in 22 neonates to estimate the values of light absorption coefficient and reduce d scattering coefficient (μ’s), cerebral Hb oxygen saturation (Sco2), cerebral blood volume (CBV), and differential path-length factor (DPF), and the relatio nships between postconceptional age and μ’s, Sco2, CBV, and DPF were investigated. A portable three-wavelength TRS system with a probe attached to the head of the neonate was used. The mean μ’s values at 761, 795, and 835 nm in neonates were estimated to be (mean ±SD ) 6.46 ±1.21, 5.90 ±1.15 and 6.40 ±1.16/cm, respectively. There was a signifi cant positive relationship between postconceptional age and μ’s at those three wavelengths. The mean Sco2 value was calculated to be 70.0 ±4.6%, and postcon ceptional age and Sco2 showed a negative linear relationship. The mean value of CBV was 2.31 ±0.56 mL/100 g. There was a significant positive relationship betw een postconceptional age and CBV. The mean DPF values at 761, 795, and 835 nm we re estimated to be 4.58 ±0.41, 4.64 ±0.46, and 4.31 ±0.42, respectively. Ther e was no relationship between postconceptional age and DPF at those three wavele ngths. The results demonstrated that our near-infrared TRS method can be used t o monitor μ’s, Sco2, CBV, and DPF in the neonatal brain at the bedside in an i ntensive care unit.展开更多
Cerebral blood flow and output of the left ventricle were simultaneously investigated in 17 infants using multichannel near infrared spectroscopy and pulse dye densitometry with indocyanine green. Cardiac output and c...Cerebral blood flow and output of the left ventricle were simultaneously investigated in 17 infants using multichannel near infrared spectroscopy and pulse dye densitometry with indocyanine green. Cardiac output and cerebral blood flow were positively related. The control of cardiac output is important in the regulation of cerebral blood flow in infants.展开更多
文摘Near-infrared spectroscopy has been used for measurement of changes in cerebr al Hb concentrations in infants to study cerebral oxygenation and hemodynamics. In this study, measurements by time-resolved spectroscopy (TRS) were performed in 22 neonates to estimate the values of light absorption coefficient and reduce d scattering coefficient (μ’s), cerebral Hb oxygen saturation (Sco2), cerebral blood volume (CBV), and differential path-length factor (DPF), and the relatio nships between postconceptional age and μ’s, Sco2, CBV, and DPF were investigated. A portable three-wavelength TRS system with a probe attached to the head of the neonate was used. The mean μ’s values at 761, 795, and 835 nm in neonates were estimated to be (mean ±SD ) 6.46 ±1.21, 5.90 ±1.15 and 6.40 ±1.16/cm, respectively. There was a signifi cant positive relationship between postconceptional age and μ’s at those three wavelengths. The mean Sco2 value was calculated to be 70.0 ±4.6%, and postcon ceptional age and Sco2 showed a negative linear relationship. The mean value of CBV was 2.31 ±0.56 mL/100 g. There was a significant positive relationship betw een postconceptional age and CBV. The mean DPF values at 761, 795, and 835 nm we re estimated to be 4.58 ±0.41, 4.64 ±0.46, and 4.31 ±0.42, respectively. Ther e was no relationship between postconceptional age and DPF at those three wavele ngths. The results demonstrated that our near-infrared TRS method can be used t o monitor μ’s, Sco2, CBV, and DPF in the neonatal brain at the bedside in an i ntensive care unit.
文摘Cerebral blood flow and output of the left ventricle were simultaneously investigated in 17 infants using multichannel near infrared spectroscopy and pulse dye densitometry with indocyanine green. Cardiac output and cerebral blood flow were positively related. The control of cardiac output is important in the regulation of cerebral blood flow in infants.
