Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s lifespan.The astrocytic regulation of neuronal activity has been increasingly recognized in recent years.Astroc...Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s lifespan.The astrocytic regulation of neuronal activity has been increasingly recognized in recent years.Astrocytes are now recognized as playing a more complex role than mere bystanders in the central nervous system.However,their role in regulating the sleep neurocircuitry is not well understood.From this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the hypothalamus.We briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.展开更多
Neuroinflammation,an intricate inflammatory process occurring in the central nervous system(CNS),plays an important role in host defense.Glial cells,including astrocytes and microglia,along with cytokines,chemokines,a...Neuroinflammation,an intricate inflammatory process occurring in the central nervous system(CNS),plays an important role in host defense.Glial cells,including astrocytes and microglia,along with cytokines,chemokines,and the complement system are important components of neuroinflammation.A low level of neuroinflammation is associated with and contributes to various homeostatic and neuroprotective processes,such as removing pathogens or cellular debris and promoting tissue repair after brain injury.展开更多
Neurodegenerative diseases,a group of disorders associated with advanced age,are typified by the disease-specific accumulation of mutant proteins and neuroinflammation.For decades,treatment modalities for these disord...Neurodegenerative diseases,a group of disorders associated with advanced age,are typified by the disease-specific accumulation of mutant proteins and neuroinflammation.For decades,treatment modalities for these disorders have focused on addressing neuronal malfu nction,which has resulted in the failure of therapies.Recent studies have identified the crucial role of glial cells in exacerbating neurodegenerative processes via the release of neuroinflammatory mediators.Glia,the major immune component of the central nervous system (CNS),undergo numerous phenotypic transitions and regulate the outcomes of various pathologies (Afridi et al.,2022).展开更多
Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.
基金supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(2017R1A5A2015391 and 2020M3E5D9079764)(to KS).
文摘Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s lifespan.The astrocytic regulation of neuronal activity has been increasingly recognized in recent years.Astrocytes are now recognized as playing a more complex role than mere bystanders in the central nervous system.However,their role in regulating the sleep neurocircuitry is not well understood.From this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the hypothalamus.We briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.
基金the National Research Foundation of Korea(NRF)grant funded by the Korean government(Nos.NRF2017R1A5A2015391,2020M3E5D9079764,to KS)。
文摘Neuroinflammation,an intricate inflammatory process occurring in the central nervous system(CNS),plays an important role in host defense.Glial cells,including astrocytes and microglia,along with cytokines,chemokines,and the complement system are important components of neuroinflammation.A low level of neuroinflammation is associated with and contributes to various homeostatic and neuroprotective processes,such as removing pathogens or cellular debris and promoting tissue repair after brain injury.
基金National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF-2017R1A5A2015391,2020M3E5D9079764)(to KS)。
文摘Neurodegenerative diseases,a group of disorders associated with advanced age,are typified by the disease-specific accumulation of mutant proteins and neuroinflammation.For decades,treatment modalities for these disorders have focused on addressing neuronal malfu nction,which has resulted in the failure of therapies.Recent studies have identified the crucial role of glial cells in exacerbating neurodegenerative processes via the release of neuroinflammatory mediators.Glia,the major immune component of the central nervous system (CNS),undergo numerous phenotypic transitions and regulate the outcomes of various pathologies (Afridi et al.,2022).
基金supported by a grant from the Basic Science Research Program through the National Research Foundation(NRF),which is funded by the Korean government(MSIP)(NRF-2020M3E5D9079764)(to KS)。
文摘Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.
