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Autophagy and neurodegenerative disorders 被引量:15
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作者 Evangelia Kesidou Roza Lagoudaki +2 位作者 Olga Touloumi kyriaki-nefeli poulatsidou Constantina Simeonidou 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第24期2275-2283,共9页
Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species a... Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders. 展开更多
关键词 neural regeneration REVIEWS oxidative stress AUTOPHAGY autophagy-related genes apoptosis Parkinson's disease amyotrophic lateral sclerosis multiple sclerosis acute and chronic neurode-generation NEUROREGENERATION
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