We formulated new skin care cosmetics with lamella structure in which high amount of pseudo-ceramides were incorporated. Consistency of this lamellar gel creams were checked for 1 month on various temperatures and for...We formulated new skin care cosmetics with lamella structure in which high amount of pseudo-ceramides were incorporated. Consistency of this lamellar gel creams were checked for 1 month on various temperatures and for 1 year on RT. Generally, multi-lamellar emulsion shows typical Maltese cross on polarized microscope, but Maltese cross was not found in case of these creams; Multi-lamellar structure of the creams could be identifed by small-angle X-ray scattering （SAXS）. To evaluate skin barrier recovery function, we applied one of this creams and a vehicle cream to forearm skin which is tape-stripped to remove barrier layer to see if they infuence mass of molecules related to barrier function. 96 h after application, we found that this lamellar gel cream promoted synthesis of ceramides, amino acids and NMFs, thereby enhanced barrier recovery function.展开更多
文摘We formulated new skin care cosmetics with lamella structure in which high amount of pseudo-ceramides were incorporated. Consistency of this lamellar gel creams were checked for 1 month on various temperatures and for 1 year on RT. Generally, multi-lamellar emulsion shows typical Maltese cross on polarized microscope, but Maltese cross was not found in case of these creams; Multi-lamellar structure of the creams could be identifed by small-angle X-ray scattering （SAXS）. To evaluate skin barrier recovery function, we applied one of this creams and a vehicle cream to forearm skin which is tape-stripped to remove barrier layer to see if they infuence mass of molecules related to barrier function. 96 h after application, we found that this lamellar gel cream promoted synthesis of ceramides, amino acids and NMFs, thereby enhanced barrier recovery function.
