Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area.The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cance...Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area.The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune response.However,inadequate biocompatibility restricts their potential in clinical translation.Therefore,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines.Intrinsic properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future nanomedicines.The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery.This review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination therapy.Herein we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical translation.This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.展开更多
基金National Research Foundation of Korea CRI project(Grant No.2018R1A3B1052702 and 2019M3E5D1A01068998,J.S.K.and NRF-2021R1A2B03002487,S.-G.C.)Basic Science Research Programs(2022R1C1C2007637,SK)of the NRF KoreaThis work was also supported by the Korea University Grant(PJ).
文摘Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area.The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune response.However,inadequate biocompatibility restricts their potential in clinical translation.Therefore,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines.Intrinsic properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future nanomedicines.The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery.This review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination therapy.Herein we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical translation.This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.
