<b>Introduction:</b> <i>Burkholderia cepacia</i> is a non-fermenting emergent bacterium common in nosocomial infections and can cause life-threatening infections whose multidrug resistance make...<b>Introduction:</b> <i>Burkholderia cepacia</i> is a non-fermenting emergent bacterium common in nosocomial infections and can cause life-threatening infections whose multidrug resistance makes them a serious threat in hospitals. The aim of this study was to determine the prevalence of <i>B. cepacia</i> infections during nosocomial infections at Libreville University teaching hospital. <b>Methodology:</b> In this cross-sectional study, lasting 19 months, 412 blood cultures were analyzed. The BacT/ALERT 3D (Biomerieux, France) was used to detect the positivity of blood culture flasks and the Viteck 2 compact (Biomerieux, France) for the identification of germs and the study of their susceptibility to antibiotics. <b>Results:</b> Our study population consisted of 412 patients. The sex-ratio M/F was 1.06 in favor of the male gender (n = 201, 51%). The age of the patients varied between 0 and 82 years. The bacteremia of <i>B. cepacia</i> mainly affected children under 15 years of age with a prevalence of 7% (n = 28). The pediatric ward was more represented with a frequency of 36% (n = 10). The antibiotic sensitivity profile showed high resistance of 100% for aminoglycosides (amikacin, tobramycin, and gentamycin), tetracycline, beta-lactams (Amoxicillin, Imipenem, Ticarcillin, Cefoxitin and Cefotaxime), and ciprofloxacin. However, four molecules were active on <i>B. cepacia</i> (Levofloxacin 100%, Trimethoprim + sulfamethoxazole 92.3%, ceftazidime 80% and cefepime 35%). <b>Conclusion:</b> Ultimately, infection and multi-resistance due to <i>Burkholderia cepacia</i> calls for a review of hospital hygiene in the pediatric ward and a review of antibiotic therapy in young children.展开更多
文摘<b>Introduction:</b> <i>Burkholderia cepacia</i> is a non-fermenting emergent bacterium common in nosocomial infections and can cause life-threatening infections whose multidrug resistance makes them a serious threat in hospitals. The aim of this study was to determine the prevalence of <i>B. cepacia</i> infections during nosocomial infections at Libreville University teaching hospital. <b>Methodology:</b> In this cross-sectional study, lasting 19 months, 412 blood cultures were analyzed. The BacT/ALERT 3D (Biomerieux, France) was used to detect the positivity of blood culture flasks and the Viteck 2 compact (Biomerieux, France) for the identification of germs and the study of their susceptibility to antibiotics. <b>Results:</b> Our study population consisted of 412 patients. The sex-ratio M/F was 1.06 in favor of the male gender (n = 201, 51%). The age of the patients varied between 0 and 82 years. The bacteremia of <i>B. cepacia</i> mainly affected children under 15 years of age with a prevalence of 7% (n = 28). The pediatric ward was more represented with a frequency of 36% (n = 10). The antibiotic sensitivity profile showed high resistance of 100% for aminoglycosides (amikacin, tobramycin, and gentamycin), tetracycline, beta-lactams (Amoxicillin, Imipenem, Ticarcillin, Cefoxitin and Cefotaxime), and ciprofloxacin. However, four molecules were active on <i>B. cepacia</i> (Levofloxacin 100%, Trimethoprim + sulfamethoxazole 92.3%, ceftazidime 80% and cefepime 35%). <b>Conclusion:</b> Ultimately, infection and multi-resistance due to <i>Burkholderia cepacia</i> calls for a review of hospital hygiene in the pediatric ward and a review of antibiotic therapy in young children.
