AIM:To explore the therapeutic effects of Morinda officinalis capsules(MOP) on osteoporosis in ovariectomized rats.METHOD:Six-month-old female Sprague–Dawley rats were induced for postmenopausal osteoporosis(PMOP) by...AIM:To explore the therapeutic effects of Morinda officinalis capsules(MOP) on osteoporosis in ovariectomized rats.METHOD:Six-month-old female Sprague–Dawley rats were induced for postmenopausal osteoporosis(PMOP) by bilateral ovariectomy and divided into seven groups as follows:sham-operated group,ovariectomized(OVX) control group,OVX treated with xianlinggubao(XLGB)(270 mg·kg-1·d-1),OVX treated with alendronate sodium(ALN)(3 mg·kg-1·d-1),and OVX treated with Morinda officinalis capsule(MOP) of graded doses(90,270 and 810 mg·kg-1·d-1) groups.Oral treatments were administered daily on the 4th week after ovariectomy and lasted for 12 weeks.The bone mineral density was evaluated by dual-energy X-ray absorptiometry.The tartrate-resistant acid phosphatase(TRAP),alkaline phosphatase(AKP),and osteocalcin(OC) levels in the serum and plasma were determined by standard colorimetric and enzyme immunoassays methods.Bone biomechanical properties and morphological parameters were analyzed by three-point bending test and histomorphometry respectively.RESULTS:Morinda officinalis capsules at all doses were able to significantly prevent the OVX-induced loss of bone mass due to diminishing serum AKP and TRAP levels while elevating OC level in the plasma.Morinda officinalis capsules also enhanced the bone strength and prevented the deterioration of trabecular microarchitecture.CONCLUSION:Morinda officinalis capsules possess potent anti-osteoporotic activity in OVX rats which could be an effective treatment for postmenopausal osteoporosis.展开更多
In this paper, to reduce the non-linear phase error caused by gamma effect of the digital projector, a novel phase difference extraction method is proposed. First, through multi-layer discrete wavelet decomposition(DW...In this paper, to reduce the non-linear phase error caused by gamma effect of the digital projector, a novel phase difference extraction method is proposed. First, through multi-layer discrete wavelet decomposition(DWT), the components of the original phase difference at different frequencies are extracted. Subsequently, the effective components are taken by the orthogonal matching pursuit(OMP) algorithm, and the phase difference is reconstructed. According to the upper and lower envelopes of the original phase difference extracted by cubic spline interpolation, the residual threshold of OMP is set. According to the results of three-dimensional(3-D) reconstruction experiment on a standard sphere, the proposed method is capable of reducing the errors in the original phase difference and achieving a better imaging result.展开更多
基金supported by the Chongqing Science and Technology Commission Foundation(No.CSTC2010-AB5070)the Projects of Chongqing Science&Technology(No.CSTC2011jjA0324)+2 种基金the Southwest University Doctor Foundation(No.SWU111065)the Fundamental ResearchFunds for Central Universities(No.XDJK2010 C059)the South-west University Doctor Foundation(No.SWU112102)
文摘AIM:To explore the therapeutic effects of Morinda officinalis capsules(MOP) on osteoporosis in ovariectomized rats.METHOD:Six-month-old female Sprague–Dawley rats were induced for postmenopausal osteoporosis(PMOP) by bilateral ovariectomy and divided into seven groups as follows:sham-operated group,ovariectomized(OVX) control group,OVX treated with xianlinggubao(XLGB)(270 mg·kg-1·d-1),OVX treated with alendronate sodium(ALN)(3 mg·kg-1·d-1),and OVX treated with Morinda officinalis capsule(MOP) of graded doses(90,270 and 810 mg·kg-1·d-1) groups.Oral treatments were administered daily on the 4th week after ovariectomy and lasted for 12 weeks.The bone mineral density was evaluated by dual-energy X-ray absorptiometry.The tartrate-resistant acid phosphatase(TRAP),alkaline phosphatase(AKP),and osteocalcin(OC) levels in the serum and plasma were determined by standard colorimetric and enzyme immunoassays methods.Bone biomechanical properties and morphological parameters were analyzed by three-point bending test and histomorphometry respectively.RESULTS:Morinda officinalis capsules at all doses were able to significantly prevent the OVX-induced loss of bone mass due to diminishing serum AKP and TRAP levels while elevating OC level in the plasma.Morinda officinalis capsules also enhanced the bone strength and prevented the deterioration of trabecular microarchitecture.CONCLUSION:Morinda officinalis capsules possess potent anti-osteoporotic activity in OVX rats which could be an effective treatment for postmenopausal osteoporosis.
基金This work has been supported by the National Natural Science Foundation of China(No.61873333)the Fundamental Research Funds of Shandong University in China(No.2018JCG06)+3 种基金the Shandong Provincial Natural Science Foundation of China(Nos.ZR2017PEE023 and ZR2017BF007)the National Key Research and Development Project(No.2018YFE02013)the Key Research and Development Plan of Shandong Province(No.2017CXGC0610)the Young Scholars Program of Shandong University(No.2016WLJH30).
文摘In this paper, to reduce the non-linear phase error caused by gamma effect of the digital projector, a novel phase difference extraction method is proposed. First, through multi-layer discrete wavelet decomposition(DWT), the components of the original phase difference at different frequencies are extracted. Subsequently, the effective components are taken by the orthogonal matching pursuit(OMP) algorithm, and the phase difference is reconstructed. According to the upper and lower envelopes of the original phase difference extracted by cubic spline interpolation, the residual threshold of OMP is set. According to the results of three-dimensional(3-D) reconstruction experiment on a standard sphere, the proposed method is capable of reducing the errors in the original phase difference and achieving a better imaging result.
