Alzheimer’s disease(AD),a neurodegenerative disease,is identified as the most common cause of dementia(Goedert and Spillantini,2006).Typical symptoms of AD in neuropathology are closely associated with changes in syn...Alzheimer’s disease(AD),a neurodegenerative disease,is identified as the most common cause of dementia(Goedert and Spillantini,2006).Typical symptoms of AD in neuropathology are closely associated with changes in synapses and neurons(Serrano-Pozo et al.,2011).The prefrontal cortex(PFC)plays a crucial role in executive function,controlling the highest level of cognitive and emotional processes,and is also vulnerable to neurodegeneration in AD(Salat et al.,2001).While synaptic degeneration is believed to underlie the progressive decline of cognition in AD,specific changes in synaptic structures relevant to AD remain elusive due to a shortage of quantitative tools.Synaptic dysfunction,while key to AD pathophysiology,is difficult to monitor and study in human AD patients.展开更多
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200 to H.H.)the Bureau of International Cooperation,Chinese Academy of Sciences(153D31KYSB20170059 to H.H.)+4 种基金Program of Beijing Municipal Science&Technology Commission(Z201100008420004 to H.H.)CAS Key Technology Talent Program(292019000126 to X.C.)National Key Research and Development Program of China(2017YFE0126500 to B.L.)National Natural Science Foundation of China(81861138013,81501105,and 31730034 to B.L.)Beijing Advanced Innovation Center for Human Brain Protection(to B.L.).
文摘Alzheimer’s disease(AD),a neurodegenerative disease,is identified as the most common cause of dementia(Goedert and Spillantini,2006).Typical symptoms of AD in neuropathology are closely associated with changes in synapses and neurons(Serrano-Pozo et al.,2011).The prefrontal cortex(PFC)plays a crucial role in executive function,controlling the highest level of cognitive and emotional processes,and is also vulnerable to neurodegeneration in AD(Salat et al.,2001).While synaptic degeneration is believed to underlie the progressive decline of cognition in AD,specific changes in synaptic structures relevant to AD remain elusive due to a shortage of quantitative tools.Synaptic dysfunction,while key to AD pathophysiology,is difficult to monitor and study in human AD patients.
