Bimatoprost (LUMIGAN) is a novel synthetic prostamide that potently lowers intraocular pressure in dogs, primates and humans. Bimatoprost is functionally and pharmacologically distinct from PGF2alpha, potently exhibit...Bimatoprost (LUMIGAN) is a novel synthetic prostamide that potently lowers intraocular pressure in dogs, primates and humans. Bimatoprost is functionally and pharmacologically distinct from PGF2alpha, potently exhibits prostamide-like activities and works directly to lower IOP. In this series of studies, confocal fluorescence microscopy was employed to compare the effects展开更多
Lumigan (Bimatoprost) is a synthetic prostamide analog with a pharmacology profile that is distinct from prostaglandins. Lumigan is also a potent and highly efficacious ocular hypotensive a-gent over a 0.001% - 0.1% d...Lumigan (Bimatoprost) is a synthetic prostamide analog with a pharmacology profile that is distinct from prostaglandins. Lumigan is also a potent and highly efficacious ocular hypotensive a-gent over a 0.001% - 0.1% dose range. To closely represent events that would occur in human subjects who receive Lumigan, two ocular distribution and metabolism studies on Lumigan展开更多
Purpose: Memantine, an uncompetitive NMDA receptor channel blocker has been used in the treatment of Parkinson’s disease and dementia. This study was done to evaluate the neu-roprotective effeet of memantine...Purpose: Memantine, an uncompetitive NMDA receptor channel blocker has been used in the treatment of Parkinson’s disease and dementia. This study was done to evaluate the neu-roprotective effeet of memantine in different retinal ganglion cell (RGC) injury models in rats. Methods: Neuroprotective effect of memantine was tested in calibrated optic nerve展开更多
文摘Bimatoprost (LUMIGAN) is a novel synthetic prostamide that potently lowers intraocular pressure in dogs, primates and humans. Bimatoprost is functionally and pharmacologically distinct from PGF2alpha, potently exhibits prostamide-like activities and works directly to lower IOP. In this series of studies, confocal fluorescence microscopy was employed to compare the effects
文摘Lumigan (Bimatoprost) is a synthetic prostamide analog with a pharmacology profile that is distinct from prostaglandins. Lumigan is also a potent and highly efficacious ocular hypotensive a-gent over a 0.001% - 0.1% dose range. To closely represent events that would occur in human subjects who receive Lumigan, two ocular distribution and metabolism studies on Lumigan
文摘Purpose: Memantine, an uncompetitive NMDA receptor channel blocker has been used in the treatment of Parkinson’s disease and dementia. This study was done to evaluate the neu-roprotective effeet of memantine in different retinal ganglion cell (RGC) injury models in rats. Methods: Neuroprotective effect of memantine was tested in calibrated optic nerve
