Compound A was isolated from endophytic fungus( No.2526) of mangrove Avicennia from the South China Sea. The structure of compound A was elucidated by compr ehensive spectral data and coincided with that of sterigmato...Compound A was isolated from endophytic fungus( No.2526) of mangrove Avicennia from the South China Sea. The structure of compound A was elucidated by compr ehensive spectral data and coincided with that of sterigmatocystin. Compound A s howed a weak cytotoxic activity against Bel-7402 and NCIH-460 in vitro wit h IC 50 96 53×10 -6 and 72 52×10 -6 g/mL respectively. It is the first report on sterigmatocystin that isolated from marine fungus.展开更多
A new sterol, ergosta-8(9),22-diene-3,5,6,7-tetraol(3β,5α,6β,7α,22E)(A) together with three known sterols: 3β, 5α,6β-trihydroxyergosta-7,22-diene (B), 3β-hydroxy-5α,8α- epidioxyer-gosta-6,22-diene (C) and er...A new sterol, ergosta-8(9),22-diene-3,5,6,7-tetraol(3β,5α,6β,7α,22E)(A) together with three known sterols: 3β, 5α,6β-trihydroxyergosta-7,22-diene (B), 3β-hydroxy-5α,8α- epidioxyer-gosta-6,22-diene (C) and ergosterol (D) were isolated from the mycelia of an unidentified endophytic fungus separated from Castaniopsis fissa (chestnut tree). Compound A exhibited potent selective cytotoxicity against Bel-7402, NCI4460 and L-02 cell lines with IC50 values 8.445, 5.03, 13.621 μg/mL, respectively.展开更多
文摘Compound A was isolated from endophytic fungus( No.2526) of mangrove Avicennia from the South China Sea. The structure of compound A was elucidated by compr ehensive spectral data and coincided with that of sterigmatocystin. Compound A s howed a weak cytotoxic activity against Bel-7402 and NCIH-460 in vitro wit h IC 50 96 53×10 -6 and 72 52×10 -6 g/mL respectively. It is the first report on sterigmatocystin that isolated from marine fungus.
文摘A new sterol, ergosta-8(9),22-diene-3,5,6,7-tetraol(3β,5α,6β,7α,22E)(A) together with three known sterols: 3β, 5α,6β-trihydroxyergosta-7,22-diene (B), 3β-hydroxy-5α,8α- epidioxyer-gosta-6,22-diene (C) and ergosterol (D) were isolated from the mycelia of an unidentified endophytic fungus separated from Castaniopsis fissa (chestnut tree). Compound A exhibited potent selective cytotoxicity against Bel-7402, NCI4460 and L-02 cell lines with IC50 values 8.445, 5.03, 13.621 μg/mL, respectively.
基金This work was supported by the National Natural Science Foundation of China(0072058)863 Foundation of China(2003AA624010)+2 种基金the National Natural Science Foundation of Guangdong Province,China(021732,2003A 3050401)a strategic grant at City University of Hong Kong(7000650)E.B.G.J.acknowledges the Royal Society,U.K.and City University of Hong Kong for the award of the Kan Tong Po Visiting Professorship.
