目的 通过荟萃分析探讨原发性面肌痉挛(hemifacial spasm,HFS)患者脑功能和结构的改变特点,进一步了解HFS的病理生理机制。方法收集2023年4月之前发表在相关数据库中关于HFS患者静息态功能磁共振成像(rest-state functional Magnetic re...目的 通过荟萃分析探讨原发性面肌痉挛(hemifacial spasm,HFS)患者脑功能和结构的改变特点,进一步了解HFS的病理生理机制。方法收集2023年4月之前发表在相关数据库中关于HFS患者静息态功能磁共振成像(rest-state functional Magnetic resonance imaging,Rs-fMRI)和基于体素的形态学分析方法(voxel-based morphometry,VBM)的所有文章。根据纳入和排除标准筛选后,采用激活似然估计(activation likelihood estimation,ALE)方法进行meta分析。结果共纳入7篇文献、10项研究(原发性面肌痉挛患者315例,健康受试者315名),对低频振荡幅度(amplitude of low frequency fluctuation,ALFF)、低频振荡分数(Fractional amplitude of low-frequency fluctuation,fALFF)及局部一致性(regional homogeneity,ReHo)等RsfMRI指标进行功能分析。ALE-meta结果显示,相对于健康受试者,HFS患者的自发性脑功能活动在中央前回、后扣带回、脑桥及小脑显著升高,而在额中回及颞上回降低。将所有基于VBM的HFS患者灰质改变的文献进行结构分析,结果显示,相对于健康受试者,HFS患者的海马旁回、丘脑体积显著减小。结论HFS患者存在脑功能和结构的改变,主要表现为中央前回、脑桥、小脑和后扣带回脑区自发性脑功能活动的异常,以及突显网络结构的异常,初步阐明了HFS患者静息态脑功能活动及结构改变的规律及特征。展开更多
Background The correlation between cognitive function and lipid profiles,including total cholesterol,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and triglycerides,is inconsist...Background The correlation between cognitive function and lipid profiles,including total cholesterol,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and triglycerides,is inconsistent.Aims This cross-sectional study investigated the association between serum lipid levels and the prevalence of cognitive impairment among community-dwelling older adults and explored this difference in association by gender and urban-rural residency.Methods Participants aged 65 and above in urban and rural areas were recruited between 2018 and 2020,selected from the Hubei Memory and Aging Cohort Study.Detailed neuropsychological evaluations,clinical examinations and laboratory tests were conducted in community health service centres.Multivariate logistic regression was used to analyse the correlation between serum lipid profiles and the prevalence of cognitive impairment.Results We identified 1336 cognitively impaired adults(≥65 years)-1066 with mild cognitive impairment and 270 with dementia-from 4746 participants.Triglycerides level was correlated with cognitive impairment in the total sample(χ2=6.420,p=0.011).In gender-stratified multivariate analysis,high triglycerides in males reduced the risk of cognitive impairment(OR:0.785,95%CI:0.623 to 0.989,p=0.040),and high LDL-C in females increased the risk of cognitive impairment(OR:1.282,95%CI:1.040 to 1.581,p=0.020).In both gender-stratified and urban-rural stratified multivariate analyses,high triglycerides reduced the risk of cognitive impairment in older urban men(OR:0.734,95%CI:0.551 to 0.977,p=0.034),and high LDL-C increased the risk of cognitive impairment in older rural women(OR:1.830,95%CI:1.119 to 2.991,p=0.016).Conclusions There are gender and urban-rural differences in the correlation of serum lipids with cognitive impairment.High triglycerides levels may be a protective factor for cognitive function in older urban men,while high LDL-C levels may be a risk factor for cognitive function in older rural women.展开更多
To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic creat...To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern.展开更多
background Substantial variations in the prevalence of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MC...background Substantial variations in the prevalence of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MCI and its subtypes in rural areas of less developed central China.Aims The study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province,China.Methods Participants aged 65 years or older were recruited between 2018 and 2019.Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.results Among 2644 participants without dementia,735 had MCI,resulting in a prevalence of 27.8%for total MCI,20.9%for amnestic MCI(aMCI)and 6.9%for non-amnestic MCI(naMCI).The prevalence of MCI in urban and rural areas was 20.2%and 44.1%,respectively.After adjusting for demographic factors,the prevalence of total MCI,aMCI and naMCI differed significantly between rural and urban areas(adjusted odds ratio(OR)2.10,1.44 and 3.76,respectively).Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.Conclusions Our findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas,such as Shanghai,but the prevalence in rural areas is twice that in urban areas.Prospective studies and dementia prevention in China should focus on rural areas.展开更多
Based on the survey data of major grain growers in Jiaojiang District,we make a thorough inquiry into the current situation and various problems concerning major grain growers in this district,explore the factors that...Based on the survey data of major grain growers in Jiaojiang District,we make a thorough inquiry into the current situation and various problems concerning major grain growers in this district,explore the factors that affect major grain growers' operation behavior,and set forth corresponding countermeasures for solving these problems and promoting further development.展开更多
Adoption of new agricultural variety is an important way to improve the efficiency of agricultural production and farmer's income.According to survey data on the 279 farmers in Huaxia,Henan Province,this paper mad...Adoption of new agricultural variety is an important way to improve the efficiency of agricultural production and farmer's income.According to survey data on the 279 farmers in Huaxia,Henan Province,this paper made an empirical analysis on influencing factors of the farmer's adoption behavior for new maize variety by using the binary Logistic model. The results showed that farmer's educational level,whether or not demonstration family,the main source of household income,the maize planting area,farmer's awareness of new variety,farmer's risk attitude as well as the times to contract with agricultural inspector all had significantly positive effects on adoption of new maize variety. Whether or not the family had cadres had significantly negative effect on the adoption of new maize variety.展开更多
Introducing a magnetic-field gradient into an electrically driven chemical reaction is expected to give rise to intriguing research possibilities.In this work,we elaborate on the modes and mechanisms of electrocatalyt...Introducing a magnetic-field gradient into an electrically driven chemical reaction is expected to give rise to intriguing research possibilities.In this work,we elaborate on the modes and mechanisms of electrocatalytic activity(from the perspective of alignment of magnetic moments)and selectivity(at the molecular level)for the CO_(2)reduction reaction in response to external magnetic fields.We establish a positive correlation between magnetic field strengths and apparent current densities.This correlation can be rationalized by the formation of longer-range ordering ofmagnetic moments and the resulting decrease in the scattering of conduction electrons and charge-transfer resistances as the field strength increases.Furthermore,aided by the magnetic-field-equipped operando infrared spectroscopy,we find that applied magnetic fields are capable of weakening the C–O bond strength of the key intermediate*COOH and elongating the C–O bond length,thereby increasing the faradaic efficiency for the electroreduction of CO_(2)to CO.展开更多
The adverse impact of the outbreak of COVID-19 has reduced ports’ operational efficiency. In addition, ports and inland logistics providers are generally independent of each other and difficult to work together, whic...The adverse impact of the outbreak of COVID-19 has reduced ports’ operational efficiency. In addition, ports and inland logistics providers are generally independent of each other and difficult to work together, which leads to time loss. Thus, as the core player, ports can integrate with inland logistics providers to improve the efficiency and resilience of maritime supply chains. This study examines the strategic options of two competing maritime supply chains consisting of ports and inland logistics providers. We investigate the impact of cooperation between ports and inland logistics providers and government regulation on the maritime supply chain by comparing members’ optimal pricing and overall social welfare under centralized, decentralized, and hybrid scenarios. Results indicate that the hybrid scenario is an equilibrium strategy for maritime supply chain, although this strategy is not optimal for governments seeking to improve supply chain resilience and maximize social welfare. Furthermore, observations show that through government economic intervention, both seaborne supplies can be incentivized to adopt an integrated strategy, and business and society can achieve a win–win situation.展开更多
Quantum stochastic phase estimation has many applications in the precise measurement of various physical parameters.Similar to the estimation of a constant phase,there is a standard quantum limit for stochastic phase ...Quantum stochastic phase estimation has many applications in the precise measurement of various physical parameters.Similar to the estimation of a constant phase,there is a standard quantum limit for stochastic phase estimation,which can be obtained with the Mach-Zehnder interferometer and coherent input state.Recently,it has been shown that the stochastic standard quantum limit can be surpassed with nonclassical resources such as squcezed light.However,practical methods to achieve quantum enhancement in the stochastic phase estimation remain largely unexplored.Here we propose a method utilizing the SU(1,1)interferometer and coherent input states to cstimate a stochastic optical phase.As an example,we investigate the Ornstcin-Uhlenback stochastic phase.We analyze the performance of this method for three key estimation problems:prediction,tracking,and smoothing.The results show significant reduction of the mean square error compared with the Mach-Zehnder interferometer under the same photon number flux inside the interferometers.In particular,we show that the method with the SU(1,1)interferometer can achieve fundamental quantum scaling,achieve stochastic Heisenberg scalinga and surpass the precision of the canonical measurement.展开更多
文摘目的 通过荟萃分析探讨原发性面肌痉挛(hemifacial spasm,HFS)患者脑功能和结构的改变特点,进一步了解HFS的病理生理机制。方法收集2023年4月之前发表在相关数据库中关于HFS患者静息态功能磁共振成像(rest-state functional Magnetic resonance imaging,Rs-fMRI)和基于体素的形态学分析方法(voxel-based morphometry,VBM)的所有文章。根据纳入和排除标准筛选后,采用激活似然估计(activation likelihood estimation,ALE)方法进行meta分析。结果共纳入7篇文献、10项研究(原发性面肌痉挛患者315例,健康受试者315名),对低频振荡幅度(amplitude of low frequency fluctuation,ALFF)、低频振荡分数(Fractional amplitude of low-frequency fluctuation,fALFF)及局部一致性(regional homogeneity,ReHo)等RsfMRI指标进行功能分析。ALE-meta结果显示,相对于健康受试者,HFS患者的自发性脑功能活动在中央前回、后扣带回、脑桥及小脑显著升高,而在额中回及颞上回降低。将所有基于VBM的HFS患者灰质改变的文献进行结构分析,结果显示,相对于健康受试者,HFS患者的海马旁回、丘脑体积显著减小。结论HFS患者存在脑功能和结构的改变,主要表现为中央前回、脑桥、小脑和后扣带回脑区自发性脑功能活动的异常,以及突显网络结构的异常,初步阐明了HFS患者静息态脑功能活动及结构改变的规律及特征。
基金Financial support for the present study was received from Ministry of Science and Technology of China(No 2020YFC2006000).
文摘Background The correlation between cognitive function and lipid profiles,including total cholesterol,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and triglycerides,is inconsistent.Aims This cross-sectional study investigated the association between serum lipid levels and the prevalence of cognitive impairment among community-dwelling older adults and explored this difference in association by gender and urban-rural residency.Methods Participants aged 65 and above in urban and rural areas were recruited between 2018 and 2020,selected from the Hubei Memory and Aging Cohort Study.Detailed neuropsychological evaluations,clinical examinations and laboratory tests were conducted in community health service centres.Multivariate logistic regression was used to analyse the correlation between serum lipid profiles and the prevalence of cognitive impairment.Results We identified 1336 cognitively impaired adults(≥65 years)-1066 with mild cognitive impairment and 270 with dementia-from 4746 participants.Triglycerides level was correlated with cognitive impairment in the total sample(χ2=6.420,p=0.011).In gender-stratified multivariate analysis,high triglycerides in males reduced the risk of cognitive impairment(OR:0.785,95%CI:0.623 to 0.989,p=0.040),and high LDL-C in females increased the risk of cognitive impairment(OR:1.282,95%CI:1.040 to 1.581,p=0.020).In both gender-stratified and urban-rural stratified multivariate analyses,high triglycerides reduced the risk of cognitive impairment in older urban men(OR:0.734,95%CI:0.551 to 0.977,p=0.034),and high LDL-C increased the risk of cognitive impairment in older rural women(OR:1.830,95%CI:1.119 to 2.991,p=0.016).Conclusions There are gender and urban-rural differences in the correlation of serum lipids with cognitive impairment.High triglycerides levels may be a protective factor for cognitive function in older urban men,while high LDL-C levels may be a risk factor for cognitive function in older rural women.
基金supported by the National Key Research and Development Programme of China(2020YFC2006000).
文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern.
基金The study was funded by the National Natural Science Foundation of China(71774127,81771488,81870901).
文摘background Substantial variations in the prevalence of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MCI and its subtypes in rural areas of less developed central China.Aims The study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province,China.Methods Participants aged 65 years or older were recruited between 2018 and 2019.Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.results Among 2644 participants without dementia,735 had MCI,resulting in a prevalence of 27.8%for total MCI,20.9%for amnestic MCI(aMCI)and 6.9%for non-amnestic MCI(naMCI).The prevalence of MCI in urban and rural areas was 20.2%and 44.1%,respectively.After adjusting for demographic factors,the prevalence of total MCI,aMCI and naMCI differed significantly between rural and urban areas(adjusted odds ratio(OR)2.10,1.44 and 3.76,respectively).Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.Conclusions Our findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas,such as Shanghai,but the prevalence in rural areas is twice that in urban areas.Prospective studies and dementia prevention in China should focus on rural areas.
文摘Based on the survey data of major grain growers in Jiaojiang District,we make a thorough inquiry into the current situation and various problems concerning major grain growers in this district,explore the factors that affect major grain growers' operation behavior,and set forth corresponding countermeasures for solving these problems and promoting further development.
基金Supported by National Natural Science Foundation(71573126)Soft Science Research Item of Jiangsu Province(BR2015043)+3 种基金Soft Science Research Item,Ministry of Agriculture(201531-1)National Soft Science Research Plan(2014GXQ4D184)Major Bidding Project of National Social Science Fund(13&ZD160)Construction Project Item of Dominant Subject of Jiangsu Colleges and Universities(PAPD)
文摘Adoption of new agricultural variety is an important way to improve the efficiency of agricultural production and farmer's income.According to survey data on the 279 farmers in Huaxia,Henan Province,this paper made an empirical analysis on influencing factors of the farmer's adoption behavior for new maize variety by using the binary Logistic model. The results showed that farmer's educational level,whether or not demonstration family,the main source of household income,the maize planting area,farmer's awareness of new variety,farmer's risk attitude as well as the times to contract with agricultural inspector all had significantly positive effects on adoption of new maize variety. Whether or not the family had cadres had significantly negative effect on the adoption of new maize variety.
基金supported by the Fundamental Research Funds for the Central Universities(2023ZDPY04).
文摘Introducing a magnetic-field gradient into an electrically driven chemical reaction is expected to give rise to intriguing research possibilities.In this work,we elaborate on the modes and mechanisms of electrocatalytic activity(from the perspective of alignment of magnetic moments)and selectivity(at the molecular level)for the CO_(2)reduction reaction in response to external magnetic fields.We establish a positive correlation between magnetic field strengths and apparent current densities.This correlation can be rationalized by the formation of longer-range ordering ofmagnetic moments and the resulting decrease in the scattering of conduction electrons and charge-transfer resistances as the field strength increases.Furthermore,aided by the magnetic-field-equipped operando infrared spectroscopy,we find that applied magnetic fields are capable of weakening the C–O bond strength of the key intermediate*COOH and elongating the C–O bond length,thereby increasing the faradaic efficiency for the electroreduction of CO_(2)to CO.
基金supported by the major projects of National Social Science Fund of China(Grant No.20&ZD130).
文摘The adverse impact of the outbreak of COVID-19 has reduced ports’ operational efficiency. In addition, ports and inland logistics providers are generally independent of each other and difficult to work together, which leads to time loss. Thus, as the core player, ports can integrate with inland logistics providers to improve the efficiency and resilience of maritime supply chains. This study examines the strategic options of two competing maritime supply chains consisting of ports and inland logistics providers. We investigate the impact of cooperation between ports and inland logistics providers and government regulation on the maritime supply chain by comparing members’ optimal pricing and overall social welfare under centralized, decentralized, and hybrid scenarios. Results indicate that the hybrid scenario is an equilibrium strategy for maritime supply chain, although this strategy is not optimal for governments seeking to improve supply chain resilience and maximize social welfare. Furthermore, observations show that through government economic intervention, both seaborne supplies can be incentivized to adopt an integrated strategy, and business and society can achieve a win–win situation.
基金National Key Research and Development Program of China(2017YFA0303703,2019YFA0308704)National Natural Science Foundation of China(11664017,11590052,11574155,51490711,61973077,91436211,91836303)+3 种基金Fundamental Research Funds for the Central Universitics(No.020214380068)Natural Science Foundjarion of Shanghai(17ZR1442900)Nanjing Universiry Innovation and Creative Program for PhD candidatc(2016017)Basic Research Project of Shanghai Science and Technology Commission(20JC1416100).
文摘Quantum stochastic phase estimation has many applications in the precise measurement of various physical parameters.Similar to the estimation of a constant phase,there is a standard quantum limit for stochastic phase estimation,which can be obtained with the Mach-Zehnder interferometer and coherent input state.Recently,it has been shown that the stochastic standard quantum limit can be surpassed with nonclassical resources such as squcezed light.However,practical methods to achieve quantum enhancement in the stochastic phase estimation remain largely unexplored.Here we propose a method utilizing the SU(1,1)interferometer and coherent input states to cstimate a stochastic optical phase.As an example,we investigate the Ornstcin-Uhlenback stochastic phase.We analyze the performance of this method for three key estimation problems:prediction,tracking,and smoothing.The results show significant reduction of the mean square error compared with the Mach-Zehnder interferometer under the same photon number flux inside the interferometers.In particular,we show that the method with the SU(1,1)interferometer can achieve fundamental quantum scaling,achieve stochastic Heisenberg scalinga and surpass the precision of the canonical measurement.
