Power equipment vibration visualization using intelligent sensing method based on event-sensing principle

Vibration measurements can be used to evaluate the operation status of power equipment and are widely applied in equipment quality inspection and fault identification.Event-sensing technology can sense the change in surface light intensity caused by object vibration and provide a visual description of vibration behavior.Based on the analysis of the principle underlying the transformation of vibration behavior into event flow data by an event sensor,this paper proposes an algorithm to reconstruct event flow data into a relationship correlating vibration displacement and time to extract the amplitude-frequency characteristics of the vibration signal.A vibration measurement test platform is constructed,and feasibility and effectiveness tests are performed for the vibration motor and other power equipment.The results show that event-sensing technology can effectively perceive the surface vibration behavior of power and provide a wide dynamic range.Furthermore,the vibration measurement and visualization algorithm for power equipment constructed using this technology offers high measurement accuracy and efficiency.The results of this study provide a new noncontact and visual method for locating vibrations and performing amplitude-frequency analysis on power equipment.

Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis.To provide clinical practice recommendations on the immune function in sepsis,an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed.Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed,Web of Science,and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire.Then,the Delphi method was used to form consensus opinions,and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions.This consensus achieved satisfactory results through two rounds of questionnaire survey,with 2 statements rated as perfect consistency,13 as very good consistency,and 9 as good consistency.After summarizing the results,a total of 14 strong recommended opinions,8 weak recommended opinions and 2 non-recommended opinions were produced.Finally,a face-to-face discussion of the consensus opinions was performed through an online meeting,and all judges unanimously agreed on the content of this consensus.In summary,this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.

3D-CTBA结合灌注区识别技术在单孔胸腔镜复杂肺段切除术中的应用

背景与目的随着肺段切除术在早期肺癌治疗中的广泛应用,如何更加精准和微创地完成肺段切除成为研究热点。本研究旨在探讨三维计算机断层支气管血管成像(three-dimensional computed tomography bronchography and angiography,3D-CTBA)结合灌注区识别技术在单孔胸腔镜复杂肺段切除术中的应用价值。方法回顾性分析2021年1月-2022年1月首都医科大学宣武医院胸外科单诊疗组连续112例单孔胸腔镜复杂肺段切除术患者的资料,总结采用三维重建结合灌注区识别技术完成手术并分析其临床数据。结果本组病例平均手术时间为(141.1±35.4)min,段间界显示初始时间为(12.5±1.7)s,段间界维持时间为(114.3±10.9)s,肺段间界均清晰显示(100%),出血量为[10(10,20)]m L,术后总引流量为(380.5±139.7)m L,术后拔管时间为(3.9±1.2)d,术后住院时间为(5.2±1.6)d。8例出现术后并发症。结论3D-CTBA结合灌注区识别技术在单孔胸腔镜复杂肺段切除术中对段间界识别具有快速、准确和安全的优点,为精准切除肿瘤、减少手术时间及降低手术并发症提供指导。

Integration of Ideological and Political Education in College Physics Courses Under the Reform of Smart Teaching

The development of the times has prompted China to enhance the quality of education and the value of talent.As guides for students,teachers should conscientiously implement ideological and political education,create college physics courses that are more in line with modern talent cultivation,eliminate the fixed and singular nature of traditional teaching,and find the integration points of ideological and political education.Teachers need to use the textbook itself,the expansion of resources in smart classrooms,and current technological progress to implement ideological and political education in order to cultivate more high-quality and high-level comprehensive talents for society.

Application of AI and IoT in Clinical Medicine:Summary and Challenges

The application of artificial intelligence(AI)technology in the medical field has experienced a long history of development.In turn,some long-standing points and challenges in the medical field have also prompted diverse research teams to continue to explore AI in depth.With the development of advanced technologies such as the Internet of Things(IoT),cloud computing,big data,and 5G mobile networks,AI technology has been more widely adopted in the medical field.In addition,the in-depth integration of AI and IoT technology enables the gradual improvement of medical diagnosis and treatment capabilities so as to provide services to the public in a more effective way.In this work,we examine the technical basis of IoT,cloud computing,big data analysis and machine learning involved in clinical medicine,combined with concepts of specific algorithms such as activity recognition,behavior recognition,anomaly detection,assistant decision-making system,to describe the scenario-based applications of remote diagnosis and treatment collaboration,neonatal intensive care unit,cardiology intensive care unit,emergency first aid,venous thromboembolism,monitoring nursing,image-assisted diagnosis,etc.We also systematically summarize the application of AI and IoT in clinical medicine,analyze the main challenges thereof,and comment on the trends and future developments in this field.

Treatment options for pulmonary multifocal ground glass opacity type adenocarcinoma: Surgery combine thermal ablation?

Objectives:To retrospectively analyze the clinical results of the treatment of pulmonary multifocal adenocarcinoma presenting as ground glass opacity(GGO)by surgery and thermal ablation.Methods:87 GGO-type pulmonary adenocarcinomas of 48 patients(14 males and 34 females;mean age:59.7 years old±9.9,range:33-79 years old)had been treated from March 2015 to March 2019.Treatment means included 43 wedge resections,7 segmentectomy,17 lobectomies,and 20 thermal ablations.The indication selected for treatment means,safety,and local tumor progression rate were evaluated.Results:No operation-related death occurred in all patients.42 times of surgery were performed and 67 carcinomas were resected in 42 patients.23 times of single-port Video-assisted thoracoscopic surgery(VATS),8 times of two-port VATS and 11 times of three-port VATS were performed in total.There were 2 cases of air leak(exceeding 1 week),1 case of chylothorax and 1 case of massive pleural effusion.Time duration of surgery was between 60 and 300 mins(mean:167 mins).Intraoperative blood loss was between 5 and 300 mL(mean:44 mL).Time of chest drainage was between 2 and 23 d(mean 4.9 d).Chest drainage volume was between 14 and 4633 mL(mean:872 mL).Post-operation LOS(length of stay)was between 3 and 25 d(mean:6.2 d).15 times of thermal ablation were performed(1 case of air leak)and 20 carcinomas were ablated in 14 patients.The ablation time was between 30 and 120 min(mean:43 min);post-operation LOS was between 1 and 10 d(mean:3.5 d).During the mean follow-up period(16 months±13)(range:5-60 months),no local tumor progression occurred.Conclusions:Surgery and thermal ablation are safe and effective options for the treatment of pulmonary multifocal GGO-type adenocarcinoma.

典型医疗废弃物热解行为及产物特性

快速热解在生产能源产品和降低环境污染方面具有明显优势,因此被视为一种优良的医疗废弃物处理技术。采用GC-MS耦合LC-HRMS的表征方法,补充了医疗废弃物热解油中高沸点难挥发组分的检测空白,准确揭示了典型医疗废弃物热解产物的组分特性及其变化规律。结果表明,棉签棒热解以生成热解油与热解炭为主,二者产率均约40%,热解气以CO和CO_(2)为主,热解油以醛酮类、酸类和酚类物质为主,特征组分为山梨酸、3-(4-羟基-3-甲氧基苯基)丙酸,随热解温度升高,CO、H_(2)及CH_(4)等可燃组分逐渐增加,醛酮类、酸类物质增加,酚类物质逐渐减少,其热解炭表面包含—OH、—CH_(x)、C=C、芳环骨架以及C—O等官能团或结构;口罩热解产物中热解油占比超过65%,基本无热解炭生成,在400℃热解程度很低,500℃时热解油产率达92.56%,600℃时约30%热解油转化为热解气,产物主要是C_(2)H_(2)和2,4-二甲基-1-庚烯,且部分烯烃会在较高温度下环化成甲苯等;手套热解油产率超60%,热解炭产率约20%,热解气以C_(1)~C_(2)烃类气体为主,热解油以烯烃和芳香烃为主,二者总量占比超过70%,D-柠檬烯是其特征组分,600℃时脂肪烃易环化生成芳香烃,其热解炭表面结构以芳环骨架为主,还有部分—OH。

Heat stroke alters hippocampal and cerebellar transmitter metabonomics

BACKGROUND:The mechanisms underlying heat stroke(HS)-induced hippocampal injury remain unclear.This study aimed to evaluate the HS-induced metabonomics of hippocampal and cerebellar transmitters.METHODS:The HS model was established with male Sprague-Dawley rats subjected to heat exposure of up to 42℃ at a humidity of(55.0±5.0)%.The hippocampal and cerebellar transmitters and metabolites of rats were tested via ultra-high-performance liquid chromatography–mass spectrometry(UPLC-MS/MS).The primary transmitters and metabolites were identified by principal component analysis(PCA)and orthogonal partial least square-discriminant analysis(OPLS-DA).The major metabolic pathways for HS were selected after enrichment.The brain injury was evaluated by histological tests.RESULTS:HS induced hippocampal and cerebellar injuries in rats.HS upregulated the protein levels of hippocampal glutamate,glutamine,gamma-aminobutyric acid,L-tryptophan(Trp),5-hydroxy-indoleacetic acid,and kynurenine;however,it downregulated asparagine,tryptamine,5-hydroxytryptophan,melatonin,3,4-dihydroxyphenylalanine(L-DOPA),and vanillylmandelic acid.HS also sharply elevated the protein levels of cerebellar methionine and Trp,and decreased the levels of serotonin,L-alanine,L-asparagine,L-aspartate,cysteine,norepinephrine,spermine,spermidine,and tyrosine.Hippocampal glutamate,monoamine transmitters,cerebellar aspartate acid,and catecholamine transmitters’metabolic pathways were identified as the main metablic pathways in HS.CONCLUSION:The hippocampus and cerebellum were injured in rats with HS,possibly induced the disorder of hippocampal glutamate and serotonin metabolism,cerebellar aspartate acid and catecholamine transmitter metabolism,and related metabolic pathways.

Highly sensitive microfiber ultrasound sensor for photoacoustic imaging

An ultrasound wave is a kind of acoustic signal with a frequency greater than 20 kHz,which is widely used in diverse fields such as medical imaging diagnosis,nondestructive testing and resource exploration.A variety of ultrasound sensors have been developed for ultrasound detection.Particularly for photoacoustic imaging,specialized ultrasound sensors with high sensitivity,small size,and broad bandwidth are needed.However,achieving such sensor perform-ance still poses a great challenge to the current state-of-the-art in ultrasound sensor technology.A recent work pub-lished in Opto-Electronic Advances(DOI:10.29026/oea.2022.200076)proposes a microfiber-based ultrasound sensor that breaks the limitations of existing ultrasound sensors.Benefiting from the large evanescent field characteristic of mi-crofiber,combined with the coherent detection technology,the proposed sensor realized highly sensitive ultrasound de-tection and demonstrated excellent performance in high-resolution photoacoustic imaging.The highly sensitive and mini-aturized microfiber ultrasound sensor provides a competitive alternative for various applications,such as endoscopic photoacoustic imaging of the intestinal tract and blood vessels in animals.

碳酸钙微球的制备及其对染料废水的吸附研究

以废弃蛋壳为钙源,十二烷基硫酸钠为模板剂,采用模板法制备碳酸钙微球。使用X射线衍射分析仪、扫描电子显微镜对其物相及形貌进行表征。将碳酸钙微球用于甲基橙吸附实验,研究碳酸钙微球的吸附性能。结果表明:成功制备了碳酸钙微球;室温下,碳酸钙微球的投入量0.2 g,甲基橙的初始质量浓度300 mg/L,吸附时间8 h,吸附率达到65%。

Identification of high oxygen-consuming substances in stormwater drainage systems illicitly connected with sewage system

The dissolved oxygen content in water is an important indicator for assessing the quality of the water environment,and maintaining a certain amount of dissolved oxygen is essential for the healthy development of the ecological environment.When a water body is anoxic,the activity of anaerobic microorganisms increases and organic matter is decomposed to produce a large number of blackening and odorizing substances,resulting in black and odorous water bodies,which is a very common and typical phenomenon in China.Presently,there is still a relatively universal occurrence of illicitly connected stormwater and sewage pipes in the urban drainage pipe network in China,which makes oxygen-consuming substances be directly discharged into rivers through stormwater pipes and consume the dissolved oxygen in the water bodies,resulting in an oxygen deficiency of the water.This induces seasonal or year-round black and stink phenomena in urban rivers.Hence,identifying high oxygen-consuming substances,which lays the foundation for the subsequent removal of oxygen-consuming substances,is essential.Through a series of comparisons of water quality indicators and analysis of organic characteristics,it was found that the oxygen consumption capacity of domestic sewage was higher than that of industrial wastewater in the selected area of this study,and the oxygen-consuming substances of domestic sewage were small molecular amino acids.By comparing 20 conventional free amino acids,it was found that seven of them consumed oxygen easily,and compared with chemical oxygen consumption,biological oxygen consumption was in a leading position.

内镜治疗结直肠癌根治术后吻合口漏疗效的影响因素分析

目的探讨内镜治疗结直肠癌根治术后吻合口漏疗效的影响因素。方法回顾性分析2015年1月—2020年12月71例行内镜辅助治疗结直肠癌根治术后吻合口漏患者的临床资料,包括性别、年龄、术前血红蛋白水平、糖化血红蛋白、血清白蛋白水平、肿瘤位置、肿瘤分期、有无新辅助化疗史、吻合口漏发生时间、内镜治疗时间、漏口大小、内镜治疗方式、术后症状缓解情况、引流液量、住院时间等。将患者按治疗效果分为完全缓解组和部分缓解组,比较2组各项指标的差异。结果71例患者中,42例内镜治疗后吻合口漏完全缓解,治疗有效率为59.15%;29例内镜治疗后漏口未完全闭合;吻合口漏治疗有效者的治疗后3 d平均引流液量少于吻合口漏未完全闭合者,差异有统计学意义(P<0.01)。完全缓解组与部分缓解组患者糖化血红蛋白水平、漏口大小、确诊吻合口漏至接受内镜治疗的时间比较,差异有统计学意义(P<0.05或P<0.01)。多因素分析发现,确诊吻合口漏至接受内镜治疗时间、漏口大小、糖化血红蛋白水平是疗效的独立影响因素(P<0.05或P<0.01)。结论确诊吻合口漏至接受内镜治疗时间、漏口大小、糖化血红蛋白水平是内镜辅助治疗结直肠癌根治术后吻合口漏疗效的独立影响因素。当发生结直肠癌吻合口漏时,应积极控制血糖及糖化血红蛋白水平,行早期内镜治疗,并根据漏口大小选择合适的方式,从而使患者获得最大的临床受益。

Na2CO3基吸附剂颗粒制备及其脱碳性能

采用挤压-滚圆法制备Na2CO3基CO2吸附剂微球颗粒,在自行设计的CO2吸收系统中对制备的样品进行脱碳性能测试。结合相关表征测试,探明不同载体、不同负载量的Na2CO3基吸附剂的微观结构、脱碳性能以及机械性能的变化规律和内在原因。研究表明:不同载体的Na2CO3基吸附剂颗粒脱碳性能存在明显差异,其中氧化铝负载的吸附剂(Na2CO3/Al2O3)的脱碳性能最好,可达1.14mmol/g。铝酸钙水泥负载的吸附剂(Na2CO3/CA)机械性能较好,但其脱碳性能最差。结合吸附剂脱碳和机械性能的综合考量,Na2CO3/Al2O3是最为合适的CO2吸附剂,并进一步研究不同Na2CO3负载量的影响。研究发现随着Na2CO3负载量的变化,吸附剂的微观结构、脱碳性能以及机械性能都存在明显的差异。虽然60%负载量的Na2CO3/Al2O3吸附剂颗粒的机械性能和脱碳效果较好,但其成球度较差,影响其实际应用。质量分数40%负载量的Na2CO3/Al2O3吸附剂颗粒具有良好的脱碳性能、机械性能以及成球度,CO2脱除量为1.36mmol/g。总体而言,利用挤压-滚圆法制备的Na2CO3基吸附剂颗粒具有良好的流动特性、脱碳性能和机械性能,适用于电厂烟气中的CO2脱除。

Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature

Background:Intracranial infection after craniotomy is one of the most serious postoperative complications,especially multidrug-resistant(MDR)or extensively drug-resistant(XDR)bacterial meningitis,and strongly affects the prognosis of patients.Current treatment experience regarding these infections is scarce.Case presentation:We report a case of severe intracranial infection of XDR Acinetobacter baumannii(A.baumannii)that was treated by intravenous(IV)injection,sequential intraventricular(IVT)injection of tigecycline and polymyxin B,and other anti-infective drugs.Good results were obtained,and the patient was eventually discharged from the hospital.This case is characterized by intracranial infection.Conclusions:The polymyxin B IV+IVT pathway is an ideal treatment strategy for XDR A.baumannii.The tigecycline IVT pathway is also a safe treatment option.

Research progress of heat stroke during 1989–2019: A bibliometric analysis

Background: Heat stroke(HS) is an acute physical disorder that is associated with a high risk of organ dysfunction and even death. HS patients are usually treated symptomatically and conservatively;however, there remains a lack of specific and effective drugs in clinical practice. An analysis of publication contributions from institutions, journals and authors in different countries/regions was used to study research progress and trends regarding HS.Methods: We extracted all relevant publications on HS between 1989 and 2019 from Web of Science. Using the Statistical Package for Social Science(SPSS, version 24) and the software GraphPad Prism 8, graphs were generated and statistical analyses were performed, while VOSviewer software was employed to visualize the research trends in HS from the perspectives of co-occurring keywords.Results: As of April 14, 2020, we identified 1443 publications with a citation frequency of 5216. The United States accounted for the largest number of publications(36.2%) and the highest number of citations(14,410), as well as the highest H-index at 74. Although the sum of publications from China ranked second, there was a contradiction between the quantity and quality of publications. Furthermore, Medicine & Science in Sports & Exercise published the most papers related to HS, with Lin MT publishing the most papers in this field(112), while the review by Knochel JP received the highest citation frequency at 969. The keyword heat-stress appeared most recently, with an average appearing year of 2015.5. In the clinical research cluster, exertional heat-stroke was determined to be the hotspot, while ambient-temperature and heat waves were the new trends in the epidemiological research cluster.Conclusions: Corresponding to this important field, while the contributions of the publications from the United States were significant, the mismatch between the quantity and quality of publications from China must be examined. Moreover, it is hypothesized that clinical and epidemiological studies may become hotspots in the near future.

组分特性对焦油黏附的影响及作用机理研究

在自行设计的焦油在线发生黏附实验台架上研究了不同焦油种类(重质生物油、轮胎热解油、废弃油脂)和不同冷凝温度(100℃,200℃)下焦油的冷凝黏附特性,并通过高分辨傅立叶变换质谱仪(FT-MS)对黏附焦油组分进行分析表征,考察了分子质量、氧原子数和分子结构对焦油黏附能力的影响。结果表明:重质生物油的黏附总量约为其他两种固体废物热解焦油黏附总量的2倍,废弃油脂的黏附总量则略高于轮胎热解油的黏附总量。三种固体废物热解焦油在200℃下的黏附量均大于在100℃下的黏附量。分子质量、氧原子数和分子结构会对焦油黏附能力造成影响,分子质量在300 Da~400 Da的组分更易发生黏附,焦油中含氧组分较烃类物质具有更强的黏附能力,含氧组分中环状含氧组分较链状含氧组分更易黏附。总体而言,大分子质量、高氧含量及多环状结构的焦油组分黏附能力更强。不同固体废物焦油因其组分特性不同,其黏附主导因素不同,三因素之间存在交互作用。小分子质量、高氧含量及多环状结构可以使得焦油组分露点温度下降,在较低温度冷凝黏附。

Molecular diversity and biogeography of benthic ciliates in the Bohai Sea and Yellow Sea

This study explored the molecular diversity and biogeography of benthic ciliates in Chinese marginal seas, the Bohai Sea(BHS), North Yellow Sea(NYS) and South Yellow Sea(SYS). From a previous 18S rRNA gene pyrosequencing dataset of the benthic microeukaryotes, we retrieved the sequences affiliated with phylum Ciliophora and analyzed alpha and beta diversities of ciliate communities. We found that BHS had the highest ciliate operational taxonomic unit(OTU) richness than NYS and SYS, whereas the richness was not significantly different between summer and winter. Among all the measured environmental variables, water depth showed consistently the strongest correlations with alpha diversities. Overall, the class Spirotrichea(mostly Choreotrichia and unassigned lineages within the class) dominated the communities in terms of both relative proportion of sequences(77.0%) and OTU richness(66.5%). OTU-level ciliate community structure was significant different among the three basins, but not between the seasons. Structurally, significant differences in relative proportion among the basins were detected for the class Litostomatea, but not for other classes. Partial Mantel tests demonstrated that water depth difference was more important than geographic and environment distances in shaping the community structure of benthic ciliates in the studied area. About 60% OTUs were not assigned at a class or order level and at least 45% OTUs shared a sequence similarity no more than 97% with the described species, indicating a great potential for ciliate species discovery in the offshore sediments. Compared with previous morphology-based surveys, the spatial pattern of ciliate diversity(decreasing from NYS to SYS) is also identified in the present study. Nevertheless, structurally, the dominant class appeared to be Spirotrichea in the sequencing dataset, which differs from previous morphology-based results(dominance of classes Prostomatea and Karyorelictea in biomass). The potential causes for the discrepancies between molecular and morphological findings are also discussed.

Properties,combustion behavior,and kinetic triplets of coke produced by low-temperature oxidation and pyrolysis:Implications for heavy oil in-situ combustion

This work aimed at investigating the crucial factor in building and maintaining the combustion front during in-situ combustion(ISC),oxidized coke and pyrolyzed coke.The surface morphologies,elemental contents,and non-isothermal mass losses of the oxidized and pyrolyzed cokes were thoroughly examined.The results indicated that the oxidized coke could be combusted at a lower temperature compared to the pyrolyzed coke due primarily to their differences in the molecular polarity and microstructure.Kinetic triplets of coke combustion were determined using iso-conversional models and one advanced integral master plots method.The activation energy values of the oxidized and pyrolyzed cokes varied in the range of 130-153 k J/mol and 95-120 kJ/mol,respectively.The most appropriate reaction model of combustion of the oxidized and pyrolyzed cokes followed three-dimensional diffusion model(D_(3)) and random nucleation and subsequent growth model(F_(1)),respectively.These observations assisted in building the numerical model of these two types of cokes to simulate the ISC process.

OpenSees Three-Dimensional Computational Modeling of Ground-Structure Systems and Liquefaction Scenarios

The OpenSees computational platform has allowed unprecedented opportunities for conducting seismic nonlinear soil-structure interaction simulations.On the geotechnical side,capabilities such as coupled solid-fluid formulations and nonlinear incrementalplasticity approaches allow for representation of the involved dynamic/seismic responses.This paper presents recent research that facilitated such endeavors in terms of response of ground-foundation-structure systems using advanced material modeling techniques and high-performance computing resources.Representative numerical results are shown for large-scale soil-structure systems,and ground modification liquefaction countermeasures.In addition,graphical user interface enabling tools for routine usage of such 3D simulation environments are presented,as an important element in support of wider adoption and practical applications.In this context,Performance-Based Earthquake Engineering(PBEE)analysis of bridge-ground systems is highlighted as an important topical application.

Pathological changes in the lung and brain of mice during heat stress and cooling treatment

BACKGROUND： Heatstroke often leads to multiple organ dysfunction syndrome （MODS） with a death rate of 40% or a neurological morbidity of 30%. These high rates in patients with heatstroke are largely due to the progression of heat stress to MODS, resulting in no specifi c treatment available. This study aimed to develop a mouse model of heat stress and determine the pathological changes in the lung and brain during heat stress and cooling treatment.METHODS： A mouse model of heat stress was established in a pre-warmed incubator set at 35.5 ± 0.5°C and with a relative humidity of 60% ± 5%. Rectal temperature was monitored, and at a temperature of 39 °C, 40 °C, 41 °C, or 42 °C, the mice were sacrifi ced. The remaining animals were removed from the incubator and cooled at an ambient temperature of 25 ± 0.5 °C and a humidity of 35% ± 5% for 12 or 24 hours at a temperature of 41 °C or for 6 hours at a temperature of 42 °C. The control mice were sham-heated at a temperature of 25 ± 0.5 °C and a humidity of 35% ± 5%. The lungs and brains of all animals were isolated. Hematoxylin and eosin staining and light microscopy were performed to detect pathological changes.RESULTS： All mice demonstrated a uniform response to heat stress. A low degree of heat stress induced marked pathological changes of the lungs. With the rise of the temperature to 42°C, progressively greater damage to the lungs with further congestion of the lung matrix, asystematic hemorrhage of alveolar space, abscission of alveolar epithelial cells, and disappearance of pulmonary alveolus tissue structure were detected. However, absorption of congestion and hemorrhage as well as recovery of pulmonary alveolus tissue structure was observed following cooling treatment at an ambient temperature. With a low degree of heat stress, the brain only showed moderate edema. Neuronal denaturation and necrosis were detected at a temperature of 42°C. Interestingly, the lesions in the brain were further aggravated at 42 °C regardless of cooling treatment, but recovery was observed after cooling treatment at 41 °C.CONCLUSIONS： The pathological changes of the lungs and brain of mice showed distinctive lesions following heat stress and cooling treatment, and they were correlated with the time and duration of cooling treatment. The results of this study are helpful for further study of the mechanisms linking heatstroke.