目的:分析我国股骨头坏死(osteonecrosis of the femoral head,ONFH)的流行病学特点。方法:从中国股骨头坏死数据库(China osteonecrosis of the femoral head database,CONFHD)中导出2016年7月至2018年12月就诊的ONFH患者的病例资料,...目的:分析我国股骨头坏死(osteonecrosis of the femoral head,ONFH)的流行病学特点。方法:从中国股骨头坏死数据库(China osteonecrosis of the femoral head database,CONFHD)中导出2016年7月至2018年12月就诊的ONFH患者的病例资料,提取的资料包括性别、年龄、体质量、身高、职业、籍贯等信息。统计患者的性别、年龄、地区、体质量指数(body mass index,BMI)及劳动强度分布情况。结果:符合要求的ONFH患者共1859例,男1314例、女545例。18~35岁286例,36~55岁930例,56~75岁571例,>75岁72例。男性患者年龄小于女性[(48.24±12.55)岁,(55.48±14.98)岁,t=-10.686,P=0.001]。华中地区529例,华东地区527例,西北地区303例,华北地区220例,华南地区219例,东北地区36例,西南地区25例。体质量过低者(BMI<18.5 kg·m^-2)64例、体质量正常者(18.5 kg·m^-2≤BMI<24.0 kg·m^-2)815例、超重者(24.0 kg·m^-2≤BMI<28.0 kg·m^-2)736例、肥胖者(BMI≥28.0 kg·m^-2)244例,其中超重和肥胖患者占53%。Ⅰ级体力劳动者(文职人员、退休人员、公务员等)362例、Ⅱ级体力劳动者(医生、教师、司机、工程师等)111例、Ⅲ级体力劳动者(电工、清洁工等)15例、Ⅳ级体力劳动者(农民、工人等)998例、其他(自由职业、无业人员)373例,其中Ⅳ级体力劳动者占54%。结论:此次基于CONFHD的调查结果显示,目前我国ONFH患者男性多于女性,男性发病较女性早;超重和肥胖者及从事Ⅳ级体力劳动者所占比例较高;患者主要集中在华中、华东和西北地区。展开更多
Objective To explore the pharmacodynamic material basis and mechanism of action of volatile oil from Chuanxiong(Chuanxiong Rhizoma)-Suhexiang(Styrax)-Bingpian(Borneolum)(hereinafter referred to as C-S-B volatile oil)i...Objective To explore the pharmacodynamic material basis and mechanism of action of volatile oil from Chuanxiong(Chuanxiong Rhizoma)-Suhexiang(Styrax)-Bingpian(Borneolum)(hereinafter referred to as C-S-B volatile oil)in treating angina pectoris based on network pharmacology and to detect its protective effects against rat myocardial damage.Methods Gas chromatography-mass spectrometry(GC-MS)was used to determine the constituents of volatile oils from Chuanxiong(Chuanxiong Rhizoma),Suhexiang(Styrax),and Bingpian(Borneolum),and the targets of the three main constituents were found predicted and screened using the PharmMapper server,and Gene Cards and Coo LGe N databases.The STRING database and Cytoscape software were used to draw the protein-protein interaction(PPI)network,RStudio software was used to analyze Gene Ontology(GO)and Kyoto Encyclopedia of Genome and Genome(KEGG)pathways,and Cytoscape software was used to construct the component-target-pathwaydisease network.The rat model of myocardial injury was established by intraperitoneal injection of a large dose of isoprenaline hydrochloride.After continuous intervention with C-S-B volatile oil for 14 d,the ejection fraction(EF)and short axis shortening rate(FS)of the left ventricle were detected.The indices of myocardial damage were detected after hematoxylin-eosin(HE)staining.Results Fifteen volatile oil components from the C-S-B formula were identified.There are 470 targets of these volatile oil components and 401 angina-related genes.There are 28 core targets,including CHRM4,ADRA1 A,FGFR1,CHRM2,CYP2 A6,CHRM5,CHRM1,CHRM3,HDAC2,and MPO,etc..The results of the KEGG analysis indicated that the C-S-B formula probably interferes with the following pathways:neuroactive ligand-receptor interactions,calcium signaling,cytochrome P450 metabolism of heteropoietin,among others.The results of animal experiments showed that the C-S-B formula essential oil could significantly improve the following myocardial indices in rats with myocardial injury:EF,FS,left ventricular end-systolic diameter(LVIDs),left ventricular end-diastolic diameter(LVIDd),and stroke volume(SV),and all the differences were statistically significant(P<0.01).Conclusion The mechanism of action of volatile oil components in the C-S-B formula in treating angina pectoris was analyzed using multi-component,multi-target and multi-pathway systems,which has laid a foundation for further revealing its mechanism of action.Animal experiments have shown that the volatile oil of the C-S-B formula can improve EF,FS,and other indices of myocardial damage in a rat model,thus relieving myocardial damage caused by heart hyperactivity,improving cardiac function,and protecting against myocardial damage.展开更多
Objective To explore ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris, and to provide new ideas for the clinical treatment.Methods With “angina pectoris” as the key word, ...Objective To explore ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris, and to provide new ideas for the clinical treatment.Methods With “angina pectoris” as the key word, ancient books prescriptions and Chinese patent medicines related to angina pectoris were collected from China National Knowledge Infrastructure(CNKI), Traditional Chinese Medicine Database System, Chinese Medicine Prescription Database, New National Proprietary Chinese Medicine(2 nd edition), and Chinese Pharmacopoeia(2020 edition) from January 1, 2015 to December 31, 2021. Core highfrequency aromatic Chinese medicines were defined, and their potential medication rules were analyzed and summarized. Microsoft Access 2010 was used for data management. Data analysis software, including Excel and IBM SPSS Modeler 18.0 were used for drug association rule analysis, and Cytoscape 3.7.2 for visual display.Results There were 67 ancient books prescriptions and 258 Chinese patent medicines containing aromatic Chinese medicines treating angina pectoris collected from relevant databases. In ancient books prescriptions, there were nine aromatic Chinese medicines with the frequency ≥10, and the most commonly used medicine was Danggui(Angelicae Sinensis Radix), followed by Chenpi(Citri Reticulatae Pericarpium). There were 33 aromatic Chinese medicines with the frequency ≥10 in Chinese patent medicines, and the most commonly used medicine was Danshen(Salviae Miltiorrhizae Radix et Rhizoma), followed by Chuanxiong(Chuanxiong Rhizoma) and Sanqi(Notoginseng Radix et Rhizoma). In ancient books prescriptions, the medicines mainly belonged to intenal-warming medicines, Qi-regulating medicines, and blood circulation promoting and blood stasis removing medicines.There were eight medicine pairs with confidence equal to 100% in ancient books prescriptions, the most frequently used pairs were Chuanxiong(Chuanxiong Rhizoma) +Danggui(Angelicae Sinensis Radix), and Xiangfu(Cyperi Rhizoma) + Chenpi(Citri Reticulatae Pericarpium). In Chinese patent medicines, the aromatic Chinese medicine Chuanxiong(Chuanxiong Rhizoma) could be combined with many other Chinese medicines, among which the Confidence and Support of Chuanxiong(Chuanxiong Rhizoma) + Danshen(Salviae Miltiorrhizae Radix et Rhizoma) were at a high level.Conclusion Aromatic Chinese medicines for the treatment of angina pectoris of coronary heart disease are mainly warm, and the flavors are mainly pungent, sweet, and bitter. They mainly access to the liver, gallbladder, and pericardium meridians. The treatment of angina pectoris of coronary heart disease mainly focuses on warming heart pulse, and promoting blood circulation and removing blood stasis.展开更多
文摘目的:分析我国股骨头坏死(osteonecrosis of the femoral head,ONFH)的流行病学特点。方法:从中国股骨头坏死数据库(China osteonecrosis of the femoral head database,CONFHD)中导出2016年7月至2018年12月就诊的ONFH患者的病例资料,提取的资料包括性别、年龄、体质量、身高、职业、籍贯等信息。统计患者的性别、年龄、地区、体质量指数(body mass index,BMI)及劳动强度分布情况。结果:符合要求的ONFH患者共1859例,男1314例、女545例。18~35岁286例,36~55岁930例,56~75岁571例,>75岁72例。男性患者年龄小于女性[(48.24±12.55)岁,(55.48±14.98)岁,t=-10.686,P=0.001]。华中地区529例,华东地区527例,西北地区303例,华北地区220例,华南地区219例,东北地区36例,西南地区25例。体质量过低者(BMI<18.5 kg·m^-2)64例、体质量正常者(18.5 kg·m^-2≤BMI<24.0 kg·m^-2)815例、超重者(24.0 kg·m^-2≤BMI<28.0 kg·m^-2)736例、肥胖者(BMI≥28.0 kg·m^-2)244例,其中超重和肥胖患者占53%。Ⅰ级体力劳动者(文职人员、退休人员、公务员等)362例、Ⅱ级体力劳动者(医生、教师、司机、工程师等)111例、Ⅲ级体力劳动者(电工、清洁工等)15例、Ⅳ级体力劳动者(农民、工人等)998例、其他(自由职业、无业人员)373例,其中Ⅳ级体力劳动者占54%。结论:此次基于CONFHD的调查结果显示,目前我国ONFH患者男性多于女性,男性发病较女性早;超重和肥胖者及从事Ⅳ级体力劳动者所占比例较高;患者主要集中在华中、华东和西北地区。
文摘研究一种基于变胞铰链Ra(Reconfigurable axis)的新型3(Ra)PS变胞并联机构的可重构特性和统一运动学分析方法。根据约束螺旋系统表明,在一个构态下,(Ra)PS支链对平台没有约束,而在另一个构态下,通过改变可重构铰链Ra铰内轴线的位置,可以提供一个约束力。支链的两个构态使3(Ra)PS变胞并联机构具有4种构型,其中包括2R1T(2个旋转1个平移)、3R1T(3个旋转1个平移)、3R2T(3个旋转2个平移)和6 DOF(Degree of freedom)构型。根据支链两构态的差异,提出以一个支链构态作为另一个支链构态特例的统一运动学建模方法。在此基础上,建立3(Ra)PS变胞并联机构的驱动选择方案和可以包含4种构型的统一运动学模型。对逆运动学和正运动学进行求解,数值算例验证了理论结果的正确性。这种特殊类型的并联机构为特殊变胞机构的工作空间、路径规划和控制奠定了基础。
基金funding support from the Major Science and Technology Research and Development Special Project of Jiangxi Science and Technology Department(No.20194ABC28009)National Key Research and Development Plan(No.2018YFC1706404)。
文摘Objective To explore the pharmacodynamic material basis and mechanism of action of volatile oil from Chuanxiong(Chuanxiong Rhizoma)-Suhexiang(Styrax)-Bingpian(Borneolum)(hereinafter referred to as C-S-B volatile oil)in treating angina pectoris based on network pharmacology and to detect its protective effects against rat myocardial damage.Methods Gas chromatography-mass spectrometry(GC-MS)was used to determine the constituents of volatile oils from Chuanxiong(Chuanxiong Rhizoma),Suhexiang(Styrax),and Bingpian(Borneolum),and the targets of the three main constituents were found predicted and screened using the PharmMapper server,and Gene Cards and Coo LGe N databases.The STRING database and Cytoscape software were used to draw the protein-protein interaction(PPI)network,RStudio software was used to analyze Gene Ontology(GO)and Kyoto Encyclopedia of Genome and Genome(KEGG)pathways,and Cytoscape software was used to construct the component-target-pathwaydisease network.The rat model of myocardial injury was established by intraperitoneal injection of a large dose of isoprenaline hydrochloride.After continuous intervention with C-S-B volatile oil for 14 d,the ejection fraction(EF)and short axis shortening rate(FS)of the left ventricle were detected.The indices of myocardial damage were detected after hematoxylin-eosin(HE)staining.Results Fifteen volatile oil components from the C-S-B formula were identified.There are 470 targets of these volatile oil components and 401 angina-related genes.There are 28 core targets,including CHRM4,ADRA1 A,FGFR1,CHRM2,CYP2 A6,CHRM5,CHRM1,CHRM3,HDAC2,and MPO,etc..The results of the KEGG analysis indicated that the C-S-B formula probably interferes with the following pathways:neuroactive ligand-receptor interactions,calcium signaling,cytochrome P450 metabolism of heteropoietin,among others.The results of animal experiments showed that the C-S-B formula essential oil could significantly improve the following myocardial indices in rats with myocardial injury:EF,FS,left ventricular end-systolic diameter(LVIDs),left ventricular end-diastolic diameter(LVIDd),and stroke volume(SV),and all the differences were statistically significant(P<0.01).Conclusion The mechanism of action of volatile oil components in the C-S-B formula in treating angina pectoris was analyzed using multi-component,multi-target and multi-pathway systems,which has laid a foundation for further revealing its mechanism of action.Animal experiments have shown that the volatile oil of the C-S-B formula can improve EF,FS,and other indices of myocardial damage in a rat model,thus relieving myocardial damage caused by heart hyperactivity,improving cardiac function,and protecting against myocardial damage.
基金Jiangxi Provincial Department of Science and Technology Major Research and Development Program(20194ABC28009 and 20202BBGL73008)National Key Research and Development Program(2018YFC1706404)。
文摘Objective To explore ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris, and to provide new ideas for the clinical treatment.Methods With “angina pectoris” as the key word, ancient books prescriptions and Chinese patent medicines related to angina pectoris were collected from China National Knowledge Infrastructure(CNKI), Traditional Chinese Medicine Database System, Chinese Medicine Prescription Database, New National Proprietary Chinese Medicine(2 nd edition), and Chinese Pharmacopoeia(2020 edition) from January 1, 2015 to December 31, 2021. Core highfrequency aromatic Chinese medicines were defined, and their potential medication rules were analyzed and summarized. Microsoft Access 2010 was used for data management. Data analysis software, including Excel and IBM SPSS Modeler 18.0 were used for drug association rule analysis, and Cytoscape 3.7.2 for visual display.Results There were 67 ancient books prescriptions and 258 Chinese patent medicines containing aromatic Chinese medicines treating angina pectoris collected from relevant databases. In ancient books prescriptions, there were nine aromatic Chinese medicines with the frequency ≥10, and the most commonly used medicine was Danggui(Angelicae Sinensis Radix), followed by Chenpi(Citri Reticulatae Pericarpium). There were 33 aromatic Chinese medicines with the frequency ≥10 in Chinese patent medicines, and the most commonly used medicine was Danshen(Salviae Miltiorrhizae Radix et Rhizoma), followed by Chuanxiong(Chuanxiong Rhizoma) and Sanqi(Notoginseng Radix et Rhizoma). In ancient books prescriptions, the medicines mainly belonged to intenal-warming medicines, Qi-regulating medicines, and blood circulation promoting and blood stasis removing medicines.There were eight medicine pairs with confidence equal to 100% in ancient books prescriptions, the most frequently used pairs were Chuanxiong(Chuanxiong Rhizoma) +Danggui(Angelicae Sinensis Radix), and Xiangfu(Cyperi Rhizoma) + Chenpi(Citri Reticulatae Pericarpium). In Chinese patent medicines, the aromatic Chinese medicine Chuanxiong(Chuanxiong Rhizoma) could be combined with many other Chinese medicines, among which the Confidence and Support of Chuanxiong(Chuanxiong Rhizoma) + Danshen(Salviae Miltiorrhizae Radix et Rhizoma) were at a high level.Conclusion Aromatic Chinese medicines for the treatment of angina pectoris of coronary heart disease are mainly warm, and the flavors are mainly pungent, sweet, and bitter. They mainly access to the liver, gallbladder, and pericardium meridians. The treatment of angina pectoris of coronary heart disease mainly focuses on warming heart pulse, and promoting blood circulation and removing blood stasis.
