Nonalcoholic steatohepatitis(NASH)is a common clinical condition that can lead to advanced liver diseases.The mechanism of the diaease progression,which is lacking effective therapy,remains obsure.Therefore,there is a...Nonalcoholic steatohepatitis(NASH)is a common clinical condition that can lead to advanced liver diseases.The mechanism of the diaease progression,which is lacking effective therapy,remains obsure.Therefore,there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies.To accomplish this goal,experimental animal models that recapitulate the human disease are necessary.Currently,an increasing number of studies have focused on natural constituents from medicinal plants which have been emerged as a new hope for NASH.This review summarized the pathogenesis of NASH,animal models commonly used,and the promising targets for therapeutics.We also reviewed the natural constituents as potential NASH therapeutic agents.展开更多
基金supported by the National Natural Science Foundation of China(No.81872889)the Drug Innovation Major Project(Nos.2018ZX09711-001-007 and 2018ZX09735002-003)。
文摘Nonalcoholic steatohepatitis(NASH)is a common clinical condition that can lead to advanced liver diseases.The mechanism of the diaease progression,which is lacking effective therapy,remains obsure.Therefore,there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies.To accomplish this goal,experimental animal models that recapitulate the human disease are necessary.Currently,an increasing number of studies have focused on natural constituents from medicinal plants which have been emerged as a new hope for NASH.This review summarized the pathogenesis of NASH,animal models commonly used,and the promising targets for therapeutics.We also reviewed the natural constituents as potential NASH therapeutic agents.
