虽然妊娠期合并恶性肿瘤较为罕见,但随着女性妊娠期年龄的增大、头颈部癌症(head and neck cancer,HNC)患者的年轻化,妊娠期合并HNC的发病率略有增加。然而,目前临床尚缺乏关于妊娠期HNC的规范化诊疗标准。本研究通过系统检索PubMed数据...虽然妊娠期合并恶性肿瘤较为罕见,但随着女性妊娠期年龄的增大、头颈部癌症(head and neck cancer,HNC)患者的年轻化,妊娠期合并HNC的发病率略有增加。然而,目前临床尚缺乏关于妊娠期HNC的规范化诊疗标准。本研究通过系统检索PubMed数据库,评估孕妇(含围产期)患HNC的频率、肿瘤类型、相关因素和特异性生物标志物,并依据循证医学证据,对妊娠期合并HNC的研究进行综述,以期为临床工作提供指导。展开更多
The mountain rocks in the Dushan Complex are Sr-rich granite with a much higher Sr level than those in other crustal lithospheres in eastern China. That presents a high potential for developing Sr-rich mineral water. ...The mountain rocks in the Dushan Complex are Sr-rich granite with a much higher Sr level than those in other crustal lithospheres in eastern China. That presents a high potential for developing Sr-rich mineral water. In this study, 6 groups of rock samples, together with 30 groups of water samples, were collected. Combining with the existing data, the Sr contents in three different types of underground water were obtained, which are the Quaternary pore water, the meshed bedrock fissure water in weathered zones and the tectonic bedrock fissure water. On the basis of preliminary understanding for the distribution characteristics of Sr-rich mineral water in the Dushan Mountain region, the causes for the Sr-rich mineral water were investigated. Our results showed that the Sr content of the rocks in the studied area ranges from 988 to 1 950 μg/g. In the horizontal direction, those in both the pore water and the meshed bedrock fissure water in weathered zones show high values in the west but low ones in the east, and high ones in the south but low ones in the north. Furthermore, both types of water meet the standard for Sr-rich mineral water in the western areas. In the vertical direction, the Sr content shows the lowest value in pore water(the average value is 0.707 mg/L), middle value in the meshed bedrock fissure water in weathered zones(the average value is 1.415 mg/L) and the highest value in the tectonic bedrock fissure water(the average value is 8.331 mg/L). It was thought that the widely-developed Sr-rich granite in this region provides physical sources for the formation of Sr-rich mineral water. The continuous dissolution of Sr during underground water runoff is the internal mechanism. In addition, the hydraulic interrelations may exist between the three vertical aquifers, leading a continuous accumulation of the Sr level during infiltration.展开更多
Biting midges of the genus Culicoides(order Diptera,family Ceratopogonidae)are potential biological vectors for the transmission of certain arboviruses among humans,livestock,and wild animals.This study collected a to...Biting midges of the genus Culicoides(order Diptera,family Ceratopogonidae)are potential biological vectors for the transmission of certain arboviruses among humans,livestock,and wild animals.This study collected a total of 405 Culicoides individuals from seven animal farms located in five counties in the border areas of Yunnan Province,China,and examined the Culicoides species composition and the major arboviruses carried by the Culicoides species.The collected Culicoides were classified into seven species with variable abundances:Culicoides arakawae(5.43%,22/405),Culicoides homotomus(1.23%,5/405),Culicoides obsoletus(19.75%,80/405),Culicoides orientalis(17.28%,70/405),Culicoides oxystoma(29.38%,119/405),Culicoides peregrinus(5.68%,23/405),and Culicoides nipponensis(21.23%,86/405).Among the seven species,C.oxystoma and C.nipponensis were distributed in all the five counties with abundances of 13.33–44.87%and 10.00–46.83%,respectively,suggesting that these were the dominant species of Culicoides widespread on animal farms in the border areas.PCR was used to detect major arboviruses in the collected Culicoides specimens,including bluetongue virus(BTV),Japanese encephalitis virus,Dengue virus,Zika virus,African swine fever virus,and African horse sickness virus.Among the tested viruses,only BTV serotype 1 was tested positive in C.oxystoma specimens collected from a buffalo farm.Culicoides oxystoma was the dominant species on animal farms in the sampled areas,but it has not previously been documented as positive for BTV in China.The current results thus suggest that C.oxystoma could be an important vector for BTV transmission in these border areas,which,however,needs to be confirmed by further comprehensive experiments.Overall,the present study provides the first profile of Culicoides species on animal farms in the China,Vietnam,and Myanmar border areas,establishes the prevalence of arboviruses carried by these Culicoides species,and suggests the vector potential of C.oxystoma species for the transmission of BTV.展开更多
目的 探究认知障碍和口腔健康问题对老年人死亡风险的联合关联影响。方法 本研究采用回顾性队列研究设计,通过筛选参与美国国家健康与营养调查(The National Health and Nutrition Examination Survey, NHANES)的3706名60岁及以上的社...目的 探究认知障碍和口腔健康问题对老年人死亡风险的联合关联影响。方法 本研究采用回顾性队列研究设计,通过筛选参与美国国家健康与营养调查(The National Health and Nutrition Examination Survey, NHANES)的3706名60岁及以上的社区人群,根据健康指标纳入诊断为认知障碍和口腔健康不良的共计1973名参与者。在调整潜在混杂因素后,使用Cox比例风险回归模型检验龋齿/牙周炎或无牙颌和认知障碍对全因死亡率和心脏代谢性死亡率的综合影响。结果 随访期间,共有978名参与者死亡(其中264人死于心脏代谢性疾病)。研究发现,认知障碍、牙周炎和牙齿缺失是全因死亡率的重要预测因素。然而,龋齿与死亡率无显著相关性。汇总其预测因素并联合分析时,与健康对照组相比,罹患认知障碍和牙周炎的全因死亡风险和心脏代谢性死亡风险分别增加了83.1%和87.7%。此外,在认知障碍和牙齿缺失共同发生的情况下,全因死亡率的风险最高[调整后的风险比(adjusted hazard ratio, aHR)=1.701,95%CI(1.338,2.161)]。结论 在中老年人群中,认知障碍伴随口腔健康问题的共同存在可能与更高的死亡率相关。本研究为提高对认知障碍和口腔健康问题在老年人群中预后结局的认识提供了有力的科学依据。展开更多
文摘虽然妊娠期合并恶性肿瘤较为罕见,但随着女性妊娠期年龄的增大、头颈部癌症(head and neck cancer,HNC)患者的年轻化,妊娠期合并HNC的发病率略有增加。然而,目前临床尚缺乏关于妊娠期HNC的规范化诊疗标准。本研究通过系统检索PubMed数据库,评估孕妇(含围产期)患HNC的频率、肿瘤类型、相关因素和特异性生物标志物,并依据循证医学证据,对妊娠期合并HNC的研究进行综述,以期为临床工作提供指导。
基金financially supported by scientific research project of Hebei Geological and Mineral Resource Bureau(454-0601-YBN-VKK1)
文摘The mountain rocks in the Dushan Complex are Sr-rich granite with a much higher Sr level than those in other crustal lithospheres in eastern China. That presents a high potential for developing Sr-rich mineral water. In this study, 6 groups of rock samples, together with 30 groups of water samples, were collected. Combining with the existing data, the Sr contents in three different types of underground water were obtained, which are the Quaternary pore water, the meshed bedrock fissure water in weathered zones and the tectonic bedrock fissure water. On the basis of preliminary understanding for the distribution characteristics of Sr-rich mineral water in the Dushan Mountain region, the causes for the Sr-rich mineral water were investigated. Our results showed that the Sr content of the rocks in the studied area ranges from 988 to 1 950 μg/g. In the horizontal direction, those in both the pore water and the meshed bedrock fissure water in weathered zones show high values in the west but low ones in the east, and high ones in the south but low ones in the north. Furthermore, both types of water meet the standard for Sr-rich mineral water in the western areas. In the vertical direction, the Sr content shows the lowest value in pore water(the average value is 0.707 mg/L), middle value in the meshed bedrock fissure water in weathered zones(the average value is 1.415 mg/L) and the highest value in the tectonic bedrock fissure water(the average value is 8.331 mg/L). It was thought that the widely-developed Sr-rich granite in this region provides physical sources for the formation of Sr-rich mineral water. The continuous dissolution of Sr during underground water runoff is the internal mechanism. In addition, the hydraulic interrelations may exist between the three vertical aquifers, leading a continuous accumulation of the Sr level during infiltration.
基金supported by the National Key Research and Development Program of China(2017YFD0501805)the Natural Science Foundation of Shanghai,China(19ZR1469000)+1 种基金the Shanghai Science and Technology Development Funds(17391901600)the Project of International Science and Technology Cooperation,China(2014DFE30140)。
文摘Biting midges of the genus Culicoides(order Diptera,family Ceratopogonidae)are potential biological vectors for the transmission of certain arboviruses among humans,livestock,and wild animals.This study collected a total of 405 Culicoides individuals from seven animal farms located in five counties in the border areas of Yunnan Province,China,and examined the Culicoides species composition and the major arboviruses carried by the Culicoides species.The collected Culicoides were classified into seven species with variable abundances:Culicoides arakawae(5.43%,22/405),Culicoides homotomus(1.23%,5/405),Culicoides obsoletus(19.75%,80/405),Culicoides orientalis(17.28%,70/405),Culicoides oxystoma(29.38%,119/405),Culicoides peregrinus(5.68%,23/405),and Culicoides nipponensis(21.23%,86/405).Among the seven species,C.oxystoma and C.nipponensis were distributed in all the five counties with abundances of 13.33–44.87%and 10.00–46.83%,respectively,suggesting that these were the dominant species of Culicoides widespread on animal farms in the border areas.PCR was used to detect major arboviruses in the collected Culicoides specimens,including bluetongue virus(BTV),Japanese encephalitis virus,Dengue virus,Zika virus,African swine fever virus,and African horse sickness virus.Among the tested viruses,only BTV serotype 1 was tested positive in C.oxystoma specimens collected from a buffalo farm.Culicoides oxystoma was the dominant species on animal farms in the sampled areas,but it has not previously been documented as positive for BTV in China.The current results thus suggest that C.oxystoma could be an important vector for BTV transmission in these border areas,which,however,needs to be confirmed by further comprehensive experiments.Overall,the present study provides the first profile of Culicoides species on animal farms in the China,Vietnam,and Myanmar border areas,establishes the prevalence of arboviruses carried by these Culicoides species,and suggests the vector potential of C.oxystoma species for the transmission of BTV.
文摘目的 探究认知障碍和口腔健康问题对老年人死亡风险的联合关联影响。方法 本研究采用回顾性队列研究设计,通过筛选参与美国国家健康与营养调查(The National Health and Nutrition Examination Survey, NHANES)的3706名60岁及以上的社区人群,根据健康指标纳入诊断为认知障碍和口腔健康不良的共计1973名参与者。在调整潜在混杂因素后,使用Cox比例风险回归模型检验龋齿/牙周炎或无牙颌和认知障碍对全因死亡率和心脏代谢性死亡率的综合影响。结果 随访期间,共有978名参与者死亡(其中264人死于心脏代谢性疾病)。研究发现,认知障碍、牙周炎和牙齿缺失是全因死亡率的重要预测因素。然而,龋齿与死亡率无显著相关性。汇总其预测因素并联合分析时,与健康对照组相比,罹患认知障碍和牙周炎的全因死亡风险和心脏代谢性死亡风险分别增加了83.1%和87.7%。此外,在认知障碍和牙齿缺失共同发生的情况下,全因死亡率的风险最高[调整后的风险比(adjusted hazard ratio, aHR)=1.701,95%CI(1.338,2.161)]。结论 在中老年人群中,认知障碍伴随口腔健康问题的共同存在可能与更高的死亡率相关。本研究为提高对认知障碍和口腔健康问题在老年人群中预后结局的认识提供了有力的科学依据。
