目的探究原发性肝癌患者术前营养相关指标与患者主观整体评估(patient⁃generated subjective global assess⁃ment,PG⁃SGA)评分之间的相关性。方法选取2016年12月至2017年3月海军军医大学附属东方肝胆外科医院的120例肝癌患者为研究对象...目的探究原发性肝癌患者术前营养相关指标与患者主观整体评估(patient⁃generated subjective global assess⁃ment,PG⁃SGA)评分之间的相关性。方法选取2016年12月至2017年3月海军军医大学附属东方肝胆外科医院的120例肝癌患者为研究对象,根据PG⁃SGA量表将其分成营养不良组(PG⁃SGA评分≥4分)76例和非营养不良组(PG⁃SGA评分<4分)44例。检测2组多项术前营养相关指标,与PG⁃SGA评分进行相关性分析,并使用受试者工作特征(receiver operating character⁃istic,ROC)曲线预测诊断价值。结果120例患者中营养不良率为63.3%。营养不良组患者血液视黄醇结合蛋白(retinol⁃binding protein,RBP)为(23.2±10.8)mg/L、前白蛋白(prealbumin,PA)为(122.8±44.7)mg/L、肌酐(creatinine,Cr)为(57.9±12.5)mol/L、体质量指数(body mass index,BMI)为23.2±3.4,均显著低于非营养不良组[分别为(45.9±14.9)mg/L、(252.7±51.8)mg/L、(80.7±13.6)mol/L、25.7±3.2],差异均具有统计学意义(P<0.001)。原发性肝癌患者术前PG⁃SGA评分与RBP(r=-0.526,P<0.001)、PA(r=-0.636,P<0.001)、Cr(r=-0.612,P<0.001)及BMI(r=-0.219,P=0.016)均存在负相关关系;通过ROC曲线发现RBP(AUC=0.925,P<0.001)、PA(AUC=0.979,P<0.001)、Cr(AUC=0.906,P<0.001)和BMI(AUC=0.701,P<0.001)均有较好的诊断价值。结论原发性肝癌患者术前营养不良发生率较高。BMI以及血液RBP、PA、Cr与PG⁃SGA评分存在负相关,对肝癌患者术前的营养不良有诊断价值。展开更多
A large amount of marine noise pollution from coastal industrial construction and the water transportation industry affects the growth and development of marine life,which is a big issue threatening marine organisms.H...A large amount of marine noise pollution from coastal industrial construction and the water transportation industry affects the growth and development of marine life,which is a big issue threatening marine organisms.However,most studies have focused on vertebrates,such as marine mammals and fishes,and little is known about the effects of noise on invertebrates.Therefore,the impacts of low-frequency noise(100,300,and 500 Hz)on behavioral and physiological responsesof the sea slug(Onchidium reevesii)were investigated.Under laboratory conditions,sea slugs were stimulated with low-frequency noise at 100,300,and 500 Hz for 1 h.Then,hemolymph enzyme activities(glucose,albumin,triglycerides,superoxide dismutase,catalase,and malondialdehyde)were measured,and mRNA expression of the hsp70 gene was detected in hemolymph and the nervous system by quantitative realtime polymerase chain reaction(qRT-PCR)analysis,while expression of the hsp70 protein was analyzed by immunohistochemistry.The results demonstrated that sea slugs were away from the stimulus source under the influence of low-frequency noise compared to the control group.Enzyme activities,as well as hsp70 gene mRNA and protein expression levels,were significantly higher in the noiseexposed groups than those in the control group.Overall,these changes indicate that low-frequency noise caused oxidative stress in sea slugs in vivo,and the oxidative damage gradually increased when the noise frequency was increased from 100 to 500 Hz.展开更多
文摘目的探究原发性肝癌患者术前营养相关指标与患者主观整体评估(patient⁃generated subjective global assess⁃ment,PG⁃SGA)评分之间的相关性。方法选取2016年12月至2017年3月海军军医大学附属东方肝胆外科医院的120例肝癌患者为研究对象,根据PG⁃SGA量表将其分成营养不良组(PG⁃SGA评分≥4分)76例和非营养不良组(PG⁃SGA评分<4分)44例。检测2组多项术前营养相关指标,与PG⁃SGA评分进行相关性分析,并使用受试者工作特征(receiver operating character⁃istic,ROC)曲线预测诊断价值。结果120例患者中营养不良率为63.3%。营养不良组患者血液视黄醇结合蛋白(retinol⁃binding protein,RBP)为(23.2±10.8)mg/L、前白蛋白(prealbumin,PA)为(122.8±44.7)mg/L、肌酐(creatinine,Cr)为(57.9±12.5)mol/L、体质量指数(body mass index,BMI)为23.2±3.4,均显著低于非营养不良组[分别为(45.9±14.9)mg/L、(252.7±51.8)mg/L、(80.7±13.6)mol/L、25.7±3.2],差异均具有统计学意义(P<0.001)。原发性肝癌患者术前PG⁃SGA评分与RBP(r=-0.526,P<0.001)、PA(r=-0.636,P<0.001)、Cr(r=-0.612,P<0.001)及BMI(r=-0.219,P=0.016)均存在负相关关系;通过ROC曲线发现RBP(AUC=0.925,P<0.001)、PA(AUC=0.979,P<0.001)、Cr(AUC=0.906,P<0.001)和BMI(AUC=0.701,P<0.001)均有较好的诊断价值。结论原发性肝癌患者术前营养不良发生率较高。BMI以及血液RBP、PA、Cr与PG⁃SGA评分存在负相关,对肝癌患者术前的营养不良有诊断价值。
基金supported by the Shanghai Collaborative Innovation Center for Cultivating Elite Breeds and Green-culture of Aquaculture Animals(No.A1-3605-21-000202)the Capacity Enhancement of Aquatic Germplasm Resources Research and Support Platform of Shanghai Ocean University(No.A1-3201-20-300206).
文摘A large amount of marine noise pollution from coastal industrial construction and the water transportation industry affects the growth and development of marine life,which is a big issue threatening marine organisms.However,most studies have focused on vertebrates,such as marine mammals and fishes,and little is known about the effects of noise on invertebrates.Therefore,the impacts of low-frequency noise(100,300,and 500 Hz)on behavioral and physiological responsesof the sea slug(Onchidium reevesii)were investigated.Under laboratory conditions,sea slugs were stimulated with low-frequency noise at 100,300,and 500 Hz for 1 h.Then,hemolymph enzyme activities(glucose,albumin,triglycerides,superoxide dismutase,catalase,and malondialdehyde)were measured,and mRNA expression of the hsp70 gene was detected in hemolymph and the nervous system by quantitative realtime polymerase chain reaction(qRT-PCR)analysis,while expression of the hsp70 protein was analyzed by immunohistochemistry.The results demonstrated that sea slugs were away from the stimulus source under the influence of low-frequency noise compared to the control group.Enzyme activities,as well as hsp70 gene mRNA and protein expression levels,were significantly higher in the noiseexposed groups than those in the control group.Overall,these changes indicate that low-frequency noise caused oxidative stress in sea slugs in vivo,and the oxidative damage gradually increased when the noise frequency was increased from 100 to 500 Hz.
