Clinical Application of Sex Hormone in Different Physiological Periods in the Diagnosis of Infertility Patients

Background: Infertility is characterized by the inability to conceive after a year of regular unprotected intercourse. Aims: This study aimed to investigate the diagnostic value of sex hormone levels during different physiological periods in the diagnosis of infertility patients. Methods: From December 2019 to May 2021, a total of 93 infertility patients were admitted and selected as the observation group. Among them, 31 cases were in the follicular stage, 31 cases in the ovulation stage, and 31 cases in the luteal stage. Ninety-three healthy women for fertility evaluation due to male infertility were selected as the control group. The control group included 31 women in the follicular phase, 31 women in the ovulatory phase, and 31 women in the luteal phase. The levels of sex hormones (prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), testosterone (T), and progesterone (P)) during different physiological phases were compared between the observation and control groups. Results: The follicular phase showed no significant difference in LH levels between the observation group and the control group. The observation group showed higher levels of PRL and P compared to the control group, while the levels of FSH, E2, and T were lower in the observation group compared to the control group. The ovulation phase showed no significant difference in PRL levels between the two groups. The observation group showed lower levels of LH, FSH, E2, T, and P compared to the control group. The luteal phase showed no statistical difference in E2 levels between the two groups. The observation group showed higher levels of PRL, LH, and FSH compared to the control group, while the levels of T and P were lower in the observation group compared to the control group. Conclusion: Infertile women show variations in hormone levels compared to the normal levels during the follicular phase, ovulatory phase, and luteal phase.

Boosting High-Voltage Practical Lithium Metal Batteries with Tailored Additives

The lithium(Li)metal anode is widely regarded as an ideal anode material for high-energy-density batteries.However,uncontrolled Li dendrite growth often leads to unfavorable interfaces and low Coulombic efficiency(CE),limiting its broader application.Herein,an ether-based electrolyte(termed FGN-182)is formulated,exhibiting ultra-stable Li metal anodes through the incorporation of LiFSI and LiNO3 as dual salts.The synergistic effect of the dual salts facilitates the formation of a highly robust SEI film with fast Li+transport kinetics.Notably,Li||Cu half cells exhibit an average CE reaching up to 99.56%.In particular,pouch cells equipped with high-loading lithium cobalt oxide(LCO,3 mAh cm^(-2))cathodes,ultrathin Li chips(25μm),and lean electrolytes(5 g Ah-1)demonstrate outstanding cycling performance,retaining 80%capacity after 125 cycles.To address the gas issue in the cathode under high voltage,cathode additives 1,3,6-tricyanohexane is incorporated with FGN-182;the resulting high-voltage LCO||Li(4.4 V)pouch cells can cycle steadily over 93 cycles.This study demonstrates that,even with the use of ether-based electrolytes,it is possible to simultaneously achieve significant improvements in both high Li utilization and electrolyte tolerance to high voltage by exploring appropriate functional additives for both the cathode and anode.

黄铵铁矾渣热分解反应机理及其动力学解析

针对黄铵铁矾渣侧吹熔炼熔渣稳定控制研究需求,采用热重−差热−质谱联用仪结合XRD、SEM-EDS等分析方法对其热分解过程及动力学特性进行研究。结果表明:黄铵铁矾渣中主要化合物为铵铁矾(NH_(4))Fe_(3)(SO_(4))_(2)(OH)_(6)、铁锌尖晶石(Zn,Fe)Fe_(2)O_(4)及硫酸铅PbSO_(4)、CaSO_(4)(H_(2)O)_(2)等硫酸盐。在热分解过程中,铵铁矾在380℃左右发生了脱氨、脱羟反应,生成各种硫酸盐,其机理函数为减速型α−t曲线;Fe_(2)(SO_(4))3在610℃时发生了分解,反应表观活化能E为153.07 kJ/mol,强化气体产物的扩散有助于推进反应进程;硫酸铅在1080℃左右发生分解,其反应机理遵循三维扩散,表观活化能较高(555.90 kJ/mol);硫酸铅分解的主要限制性因素是分解产物PbO在渣中的扩散,可通过降低渣系的熔点及黏度促进反应进行。

1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex

Ulcerative colitis(UC)is characterized by chronic relapsing intestinal inflammation.Currently,there is no effective treatment for the disease.According to our preliminary data,1,8-cineole,which is the main active compound of Amomum compactum Sol.ex Maton volatile oil and an effective drug for the treatment of pneumonia,showed remarkable anti-inflammatory effects on colitis pathogenesis.However,its mechanism of action and direct targets remain unclear.This study investigated the direct targets and mechanism through which 1,8-cineole exerts its anti-inflammatory effects using a dextran sulfate sodium salt-induced colitis mouse model.The effects of 1,8-cineole on macrophage polarization were investigated using activated bone marrow-derived macrophages and RAW264.7 cells.In addition,1,8-cineole targets were revealed by drug affinity responsive target stability,thermal shift assay,cellular thermal shift assay,and heat shock protein 90(HSP90)adenosine triphosphatases(ATPase)activity assays.The results showed that 1,8-cineole exhibited powerful anti-inflammatory properties in vitro and in vivo by inhibiting the macrophage M1 polarization and protecting intestinal barrier function.Mechanistically,1,8-cineole directly interacted with HSP90 and decreased its ATPase activity,also inhibited nucleotide-binding and oligomerization domain-,leucine rich repeat-,and pyrin domain-containing 3(NLRP3)binding to HSP90 and suppressor of G-two allele of SKP1(SGT1)and suppressed NLRP3 inflammasome activation in macrophages.These results demonstrated that 1,8-cineole is a potential drug candidate for UC treatment.

Kai-Xin-San regulates synaptic plasticity through calcium signaling to alleviate symptoms of depression-like behavioral disorders in mice

Background:Kai-Xin-San,a classical Chinese medicine prescription,has been widely applied in the clinical therapy for depression,but its pharmacological mechanism remains to be further explored.Based on network pharmacology,molecular docking and animal experiments,the research is performed to exploit pharmacological mechanism of Kai-Xin-San for treating depression.Methods:Obtain chemical components and potential targets of Kai-Xin-San through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,Encyclopedia of Traditional Chinese Medicine and Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine databases,and then screen the active ingredients of each herb in accordance with absorption,distribution,metabolism,and excretion.The GenCards,Online Mendelian Inheritance in Man,Therapeutic Target database and DrugBank databases were used to obtain the major targets of depression,and the STRING platform was used to construct the protein-protein interaction network and explore the potential protein functional modules in the network.The targets were subjected to Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis by STRING database and Metascape database.The interaction network of“Kai-Xin-San active components-depression-targets-pathways”was constructed by Cytoscape,and molecular docking verification was performed by Auto Dock tools.Finally,animal experiments were carried out for further verification.The chronic restraint stress depression model was established and mice were randomly divided into 4 groups:control group,chronic restraint stress group,fluoxetine group and Kai-Xin-San group.Behavioral tests were used to evaluate the depressive phenotype of mice.The expression of CaMKII-,synaptophysin,poststroke depression-95,and CACNA1C were all detected using a western blot.Results:Network analysis shows that Kai-Xin-San may mainly regulate calcium signaling pathway to exert antidepressant effects.A majority of the targets and components have good binding activity,according to the molecular docking studies.In the current study,behavioral tests showed that Kai-Xin-San could effectively alleviate depression-like behaviors in mice compared with the chronic restraint stress group,which effect was comparable to fluoxetine.Meanwhile,compared with the chronic restraint stress group,protein levels of CACNA1C,CaMKII-α,synaptophysin and poststroke depression-95 were significantly increased(P<0.05).Conclusion:The research initially identifies the multi-component,multi-target,and multi-path mechanism of Kai-Xin-San in the treatment of depression.Kai-Xin-San may improve synaptic plasticity through calcium signaling pathway to exert antidepressant effects.

从铁矾渣侧吹熔炼—烟化法烟灰中回收锌镉及其净化除杂

研究了采用酸性浸出—硫化除杂法从铁矾渣侧吹熔炼—烟化法产出的烟灰中回收锌、镉,并选择性除去浸出液中的铜,产物用以制备镉掺杂硫化锌;在热力学分析基础上,探明了硫酸体系下锌浸出率影响因素及其浸出动力学;通过正交试验明确了各参数对硫化钠选择性除杂的影响。结果表明:烟灰中锌主要以氧化锌形式存在,其浸出过程符合混合控制,表观活化能为73.70 kJ/mol;在最佳条件下,锌浸出率达98.99%。以Na_(2)S用量为理论添加量的3.2倍,控制体系pH=2.0,铜去除率可达95.97%,同时有效保留锌、镉,实现了铜与锌、镉的选择性分离。

骨科住院医师规范化培训年度考核成绩影响因素分析

目的对住院医师年度考核成绩进行分析,探讨影响年度考核成绩的相关因素。方法以中山大学孙逸仙纪念医院骨外科2021年二、三年级住院医师年度考核成绩为住院医师年度培训效果得分,对其性别、年龄、学历、婚姻状况、学员类型、入培摸底测试成绩、教学活动出勤情况、日常培训成绩进行影响因素分析。结果二年级住院医师培训效果影响因素包括日常理论考核(P=0.002)和日常技能考核(P=0.023);而三年级的影响因素包括教学活动出勤比例(P=0.017)、日常理论考核(P=0.016)和日常技能考核(P=0.050)。结论日常住院医师规范化培训(简称住培)工作的落实与日常临床工作与培训的密切相关,通过加强监督与及时调整个体化教学策略,有利于提高住培效果,是实现“出口同质”,增强住院医师岗位胜任力的重要举措。

中西部地区混凝土拌合站规模与费用测定研究

混凝土拌合站是铁路项目重要的大型临时工程设施,混凝土拌合站费用的精准确定对保障铁路建设投资合理性有着重要意义。本文突破以往混凝土集中拌合站设计只采用统一指标计列工程费用的模式,综合考虑整体规模以及场地地形等因素引起混凝土拌合站主要工程数量的变化,对中西部地区混凝土拌合站的设计补充制定相应原则,并对其主要工程数量及概算指标进行测定分析,以提高费用计列的精度及准确性。本文的研究成果将为今后中西部地区混凝土拌合站的设计提供参考和依据,也为不同类型的混凝土拌合站费用的计列提供理论支撑。

Improved nuclear mass formula with an additional term from the Fermi gas model

Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear astrophysics.Owing to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models cannot completely describe nuclear binding energies.In this study,the mass formula was improved by considering an additional term from the Fermi gas model.All nuclear masses in the Atomic Mass Evaluation Database were reproduced with a root-mean-square deviation(RMSD)of -1.86 MeV(1.92 MeV).The new mass formula exhibits good performance in the neutron-rich nuclear region.The RMSD decreases to 0.393 MeV when the ratio of the neutron number to the proton number is≥1.6.

Market Operation of Energy Storage System in Smart Grid:A Review

As a flexible resource,energy storage plays an increasingly significant role in stabilizing and supporting the power system,while providing auxiliary services.Still,the current high demand for energy storage contrasts with the fuzzy lack of market-oriented mechanisms for energy storage,the principle of market-oriented operation has not been embodied,and there is no unified and systematic analytical framework for the business model.However,the dispatch management model of energy storage in actual power system operation is not clear.Still,the specific scheduling process and energy storage strategy on the source-load-network side could be more specific,and there needs to be a greater understanding of the collaborative scheduling process of the multilevel scheduling center.On this basis,this paper reviews the energy storage operation model and market-based incentive mechanism,For different functional types and installation locations of energy storage within the power system,the operational models and existing policies for energy storage participation in the market that are adapted to multiple operating states are summarized.From the point of view of the actual scheduling and operation management of energy storage in China,an energy storage regulation and operation management model based on“national,provincial,and local”multilevel coordination is proposed,as well as key technologies in the interactive scenarios of source-load,network and storage.

油田注水结垢规律及化学防治措施研究

鄂尔多斯盆地X区块多层系同时开发,不同层位采出水未做分离,混合后用于回注作业造成注入压力升高。本文通过静态模拟实验测试分析了X区块已开发的S、M、Z 3个层位采出水及其混合水的结垢规律,并通过测试透光率、岩芯伤害率分析了各层采出水配伍性,最后对5种类型化学除垢剂进行评价优选实验。研究表明,X区块S、Z层采出水为CaCl_(2)水型,M层采出水为Na_(2)SO_(4)水型,相同水型任意比混配在40~90℃内结垢量甚微,且配伍性良好;S层/M层、M层/Z层产出水混合后结垢量较大,配伍性差,分别在1∶1与3∶1的质量比条件下出现最大结垢量以及对岩芯的最大伤害率;有机复合膦酸防垢剂相对于磷酸盐、磷酸酯以及羧酸类防垢剂体现出最佳防垢效果与最低用量,防垢剂临界浓度为10~15 mg·L^(-1),防垢率达到95.8%。

基于“水-能-碳”关联系统的城镇污水处理厂碳排放研究

在“双碳”战略背景下,有效地核算污水处理厂碳排放量对节能减碳具有重要意义。基于“水-能-碳”关联系统,构建新型核算体系,并以长江中下游某城镇污水厂为案例,开展碳排放量核算。结果表明,常规情况下污水厂碳排放总量达208211.97 kgCO_(2)/d,直接碳排放为主要排放源,各子碳排放系统中CH_(4)类碳排放量占比最高,达48.26%。最后,针对核算结果,提出污水处理厂减碳措施与建议,以期为后来的研究者、工程技术人员研究同类问题提供参考。

骨科见习教学中应用改良LBL-PBL-LBL教学模式的效果分析

目的使用调查问卷和考试成绩评价改良LBLPBL-LBL教学模式对于骨科临床见习的教学效果。方法选取2020年8月至2021年4月参加临床见习的五年制临床医学本科生共118名,分为对照组和研究组两组,对照组采用传统的以授课为基础的教学法(lecture-based learning,LBL),研究组使用改良LBL-PBL-LBL教学模式。综合评教问卷和考试成绩来评价改良LBL-PBL-LBL教学模式对骨科临床见习的教学效果。结果相比于对照组,研究组的教学效果评分更高,差异有统计学意义(P<0.05);在考试成绩方面,研究组学生的理论考试和实践技能考试的分数也更高,差异有统计学意义(P<0.05)。结论改良LBL-PBL-LBL教学模式是一种可以显著改善骨科临床见习教学效果的教学模式,可以在骨科临床见习教学中广泛应用。

Transfection of the glial cell line-derived neurotrophic factor gene promotes neuronal differentiation

Glial cell line-derived neurotrophic factor recombinant adenovirus vector-transfected bone marrow mesenchymal stem cells were induced to differentiate into neuron-like cells using inductive medium containing retinoic acid and epidermal growth factor. Cell viability, micro- tubule-associated protein 2-positive cell ratio, and the expression levels of glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein-43 protein in the su- pernatant were significantly higher in glial cell line-derived neurotrophic factor/bone marrow mesenchymal stem cells compared with empty virus plasmid-transfected bone marrow mes- enchymal stem cells. Furthermore, microtubule-associated protein 2, glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein743 mRNA levels in cell pellets were statistically higher in glial cell line-derived neurotrophic factor/bone marrow mesen- chymal stem cells compared with empty virus plasmid-transfected bone marrow mesenchymal stem cells. These results suggest that glial cell line-derived neurotrophic factor/bone marrow mesenchymal stem cells have a higher rate of induction into neuron-like cells, and this enhanced differentiation into neuron-like cells may be associated with up-regulated expression of glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein-43.

Electro-Optically Switchable Optical True Delay Lines of Meter-Scale Lengths Fabricated on Lithium Niobate on Insulator Using Photolithography Assisted Chemo-Mechanical Etching

Optical true delay lines(OTDLs)of low propagation losses,small footprints and high tuning speeds and efficiencies are of critical importance for various photonic applications.Here,we report fabrication of electro-optically switchable OTDLs on lithium niobate on insulator using photolithography assisted chemo-mechanical etching.Our device consists of several low-loss optical waveguides of different lengths which are consecutively connected by electro-optical switches to generate different amounts of time delay.The fabricated OTLDs show an ultra-low propagation loss of^0.03dB/cm for waveguide lengths well above 100 cm.

A high fidelity general purpose 3-D Monte Carlo particle transport program JMCT3.0

JMCT is a large-scale,high-fidelity,three-dimensional general neutron–photon–electron–proton transport Monte Carlo software system.It was developed based on the combinatorial geometry parallel infrastructure JCOGIN and the adaptive structured mesh infrastructure JASMIN.JMCT is equipped with CAD modeling and visualizes the image output.It supports the geometry of the body and the structured/unstructured mesh.JMCT has most functions,variance reduction techniques,and tallies of the traditional Monte Carlo particle transport codes.Two energy models,multi-group and continuous,are provided.In recent years,some new functions and algorithms have been developed,such as Doppler broadening on-thefly(OTF),uniform tally density(UTD),consistent adjoint driven importance sampling(CADIS),fast criticality search of boron concentration(FCSBC)domain decomposition(DD),adaptive control rod moving(ACRM),and random geometry(RG)etc.The JMCT is also coupled with the discrete ordinate SNcode JSNT to generate source-biasing factors and weight-window parameters.At present,the number of geometric bodies,materials,tallies,depletion zones,and parallel processors are sufficiently large to simulate extremely complicated device problems.JMCT can be used to simulate reactor physics,criticality safety analysis,radiation shielding,detector response,nuclear well logging,and dosimetry calculations etc.In particular,JMCT can be coupled with depletion and thermal-hydraulics for the simulation of reactor nuclear-hot feedback effects.This paper describes the progress in advanced modeling,high-performance numerical simulation of particle transport,multiphysics coupled calculations,and large-scale parallel computing.

非淹没双空化射流流场及冲击特性数值模拟

空化射流具有比同等条件下普通水射流更强的冲击力,被广泛应用于各种领域。为进一步提高空化射流的工作效率,提出了新型的非淹没双空化射流。基于多相流Mixture模型和RNG k-ε输运方程,研究了双空化喷嘴中内外喷嘴径向间距D 0与出口轴向间距L,以及外喷嘴来流压力P 1对射流轴线速度、压力、含气率与比能的影响,并分析了最优D 0,L,P 1组合下射流冲击平板的壁面压力分布特征。研究结果表明,当D 0=1.5 mm,且L=2 mm时射流的流场特性最优,在此结构下的最优靶距为20~25 mm。对该非淹没双空化射流冲击特性分析发现,相比于传统中心体空化喷嘴,其可产生体积更大的空化云和更好的冲击效果。研究结果可为空化射流的高效应用提供理论基础。

Oligomerization of 1-Decene: Catalyzation by Immobilized AlCl_3/γ-Al_2O_3 Catalyst in Fixed-bed Reactor

1-Decene was oligomerized over the supported AlCl3/γ-Al2O3 catalyst in a fixed-bed reactor. The effects of temperature and LHSV on oligomerization of 1-decene were investigated and the synthetic PAO was characterized with GC technique. Furthermore, the life of immobilized catalyst was tested and the mechanism of catalyst deactivation was discussed. The results showed that with an increasing temperature, the PAO yield increased and the kinematic viscosity of oil decreased. The GC results indicated that the synthesized PAO was a mixture consisting of dimers, trimers, tetramers and pentamers. The results of chloride content measurements and BET tests showed that catalyst deactivation could be mainly attributed to the loss of active components.

构建骨外科临床培训多维度综合评价体系的探索

目的针对住院医师临床胜任力的培训,探索骨科围绕住院医师“六大核心能力”多维度评价系统的构建及可行性。方法针对2019年9月—2020年7月中山大学孙逸仙纪念医院三年级住院医师分析既往评价方式与胜任力间对应关系,将日常培训、阶段考核、调查问卷等均归结于六大核心能力评价范畴,经教师团队讨论设置权重,构建评价体系。于2021年3—10月的三年级住院医师培训中应用,动态观察六大核心能力的变化,并开展教师及住院医师的满意度调查,以分析其可行性。结果在初步应用期间住院医师六大核心能力均持续提升,住院医师间能力掌握水平差异不断减少。对带教老师及住院医师的满意度调查中,多维度评价体系的全面性、针对性、基于评价结果所进行的反馈获益、教与学效率的提升方面均显示出较高的认可度。结论多维度评价体系设计能较为全面、直观地反映住院医师六大核心能力水平,对住院医师的能力水平变化实现多维度、个体化动态监测,有利于及时反馈,并实现个体化教学,促进临床胜任力的培养。

Fabrication of multi-shell coated silicon nanoparticles via in-situ electroless deposition as high performance anodes for lithium ion batteries

Si-based materials have been extensively studied because of their high theoretical capacity,low working potential,and abundant reserves,but serious initial irreversible capacity loss and poor cyclic performance resulting from large volume change of Si during lithiation and delithiation processes restrict their widespread application.Herein,we report the preparation of multi-shell coated Si(DS-Si)nanocomposites by in-situ electroless deposition method using Si granules as the active materials and copper sulfate as Cu sources.The ratio of Si and Cu was readily tuned by varying the concentration of copper sulfate.The multi-shell(Cu@CuxSi/SiO2)coating on Si surface promotes the formation of robust and dense SEI films and the transportation of electron.Thus,the obtained DS-Si composites exhibit an initial coulombic efficiency of 86.2%,a capacity of 1636 mAh g^-1 after 100 discharge-charge cycles at 840 mA g^-1,and an average charge capacity of 1493 mAh g^-1 at 4200 mA g^-1.This study provides a low-cost and large-scale approach to the preparation of nanostructured Si-metal composites anodes with good electrochemical performance for lithium ion batteries.