目的分析2型糖尿病患者糖基化终末产物(Advanced glycation end products,AGEs)累积量与各临床影响因素的相关性,为2型糖尿病的中医诊疗及其相关并发症的早期防治提供参考。方法选取2018年12月—2020年12月期间于开封市中医院内分泌科...目的分析2型糖尿病患者糖基化终末产物(Advanced glycation end products,AGEs)累积量与各临床影响因素的相关性,为2型糖尿病的中医诊疗及其相关并发症的早期防治提供参考。方法选取2018年12月—2020年12月期间于开封市中医院内分泌科住院的2型糖尿病患者285例,收集其AGEs、实验室检查及中医证候信息。采用描述性统计分析,非参数检验、斯皮尔曼相关性分析,最优尺度回归方法分析AGEs的相关影响因素。结果AGEs水平与果糖胺(Glycosylated serum protein,GSP)、糖化血红蛋白等实验室指标呈现相关关系,在不同中医证型中AGEs水平存在显著的差异。中医证候、年龄、病程、尿微量白蛋白是2型糖尿病患者AGEs水平的独立影响因素。结论AGEs水平与临床影响因素具有相关性,为2型糖尿病的中医诊疗及其并发症的防治提供了参考。展开更多
In order to improve the recovery of tungsten ores containing tin minerals,anisic hydroxamic acid(p-methoxy benzohydroxanic acid,PMOB)was synthesized and introduced as novel collector in the flotation of scheelite,wolf...In order to improve the recovery of tungsten ores containing tin minerals,anisic hydroxamic acid(p-methoxy benzohydroxanic acid,PMOB)was synthesized and introduced as novel collector in the flotation of scheelite,wolframite and cassiterite.The flotation performance and adsorption mechanism were investigated by micro/batch flotation,zeta potential measurements and density functional theory(DFT).The micro flotation results showed that the recoveries of scheelite,wolframite and cassiterite using PMOB as collector are 97.45%,95.77% and 90.08%,respectively,and the corresponding recoveries are 91.00%,84.30% and 84.67% for benzohydroxamic acid(BHA).The batch flotation results revealed that the collector dosage could be reduced by about 45% for PMOB compared with BHA,in the case of similar flotation indicators.Zeta potential measurements indicated that PMOB could be adsorbed on the mineral surfaces by chemisorption.Moreover,density functional theory(DFT)calculation results showed that the substituent group—OCH_(3)endues PMOB stronger electron donation ability and hydrophobicity compared with benzohydroxamic acid(BHA),pmethyl benzohydroxamic acid(PMB)and p-hydroxyl benzohydroxamic acid(PHB).展开更多
文摘目的:探讨Stanford B型主动脉夹层(TBAD)患者给予腔内修复术(EVAR)治疗对炎症因子、血管内皮生长因子(VEGF)的影响及预后。方法:选取2020年1月至2021年1月在河南省胸科医院治疗的TBAD患者47例作为研究对象,均给予EVAR治疗,统计患者围手术期指标及预后情况,比较手术前后患者的炎症因子、VEGF水平变化。结果:47例患者的术中出血量平均为(32.41±5.48)mL,手术时间平均为(1.52±0.41)h,重症监护室(ICU)入住时间平均为(13.34±3.02)h,住院时间平均为(17.24±3.45)d;术后7 d白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平较术前降低,差异均具有统计学意义(P<0.05);术后7 d VEGF水平较术前降低,差异具有统计学意义(P<0.05);患者中有5例发生并发症,发生率为10.64%,其中2例内漏,1例夹层破裂,2例胸腔积液,未发生肾功能障碍;随访1年,共3例患者再介入治疗,占6.38%,1例死亡,病死率为2.13%。结论:TBAD患者给予EVAR治疗,术中出血量较少,手术时间短,患者恢复快,能够改善炎症因子、VEGF水平,预后较好。
基金Projects(2020GDASYL-20200302009,2020GDASYL-20200302004,2019GDASYL-0501007)supported by Guandong Academy of Sciences,ChinaProject(2020YFC1909202)supported by Ministry of Science and Technology of China。
文摘In order to improve the recovery of tungsten ores containing tin minerals,anisic hydroxamic acid(p-methoxy benzohydroxanic acid,PMOB)was synthesized and introduced as novel collector in the flotation of scheelite,wolframite and cassiterite.The flotation performance and adsorption mechanism were investigated by micro/batch flotation,zeta potential measurements and density functional theory(DFT).The micro flotation results showed that the recoveries of scheelite,wolframite and cassiterite using PMOB as collector are 97.45%,95.77% and 90.08%,respectively,and the corresponding recoveries are 91.00%,84.30% and 84.67% for benzohydroxamic acid(BHA).The batch flotation results revealed that the collector dosage could be reduced by about 45% for PMOB compared with BHA,in the case of similar flotation indicators.Zeta potential measurements indicated that PMOB could be adsorbed on the mineral surfaces by chemisorption.Moreover,density functional theory(DFT)calculation results showed that the substituent group—OCH_(3)endues PMOB stronger electron donation ability and hydrophobicity compared with benzohydroxamic acid(BHA),pmethyl benzohydroxamic acid(PMB)and p-hydroxyl benzohydroxamic acid(PHB).
