Engineering Strategies for Suppressing the Shuttle Effect in Lithium–Sulfur Batteries

Lithium–sulfur(Li–S)batteries are supposed to be one of the most potential next-generation batteries owing to their high theoretical capacity and low cost.Nevertheless,the shuttle effect of firm multi-step two-electron reaction between sulfur and lithium in liquid electrolyte makes the capacity much smaller than the theoretical value.Many methods were proposed for inhibiting the shuttle effect of polysulfide,improving corresponding redox kinetics and enhancing the integral performance of Li–S batteries.Here,we will comprehensively and systematically summarize the strategies for inhibiting the shuttle effect from all components of Li–S batteries.First,the electrochemical principles/mechanism and origin of the shuttle effect are described in detail.Moreover,the efficient strategies,including boosting the sulfur conversion rate of sulfur,confining sulfur or lithium polysulfides(LPS)within cathode host,confining LPS in the shield layer,and preventing LPS from contacting the anode,will be discussed to suppress the shuttle effect.Then,recent advances in inhibition of shuttle effect in cathode,electrolyte,separator,and anode with the aforementioned strategies have been summarized to direct the further design of efficient materials for Li–S batteries.Finally,we present prospects for inhibition of the LPS shuttle and potential development directions in Li–S batteries.

A novel live attenuated vaccine candidate protects chickens against subtype B avian metapneumovirus

Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the dominant epidemic strain in China. We developed an attenuated aMPV subtype B strain by serial passaging in Vero cells and evaluated its safety and efficacy as a vaccine candidate. The safety test showed that after the 30th passage, the LN16-A strain was fully attenuated, as clinical signs of infection and histological lesions were absent after inoculation.The LN16-A strain did not revert to a virulent strain after five serial passages in chickens. The genomic sequence of LN16-A differed from that of the parent wild-type LN16(wtLN16) strain and had nine amino acid mutations. In chickens, a single immunization with LN16-A induced robust humoral and cellular immune responses, including the abundant production of neutralizing antibodies, CD4^(+) T lymphocytes, and the Th1(IFN-γ) and Th2(IL-4 and IL-6)cytokines. We also confirmed that LN16-A provided 100% protection against subtype B aMPV and significantly reduced viral shedding and turbinate inflammation. Our findings suggest that the LN16-A strain is a promising live attenuated vaccine candidate that can prevent infection with subtype B aMPV.

Experimental Investigations of Quasi-Coherent Micro-Instabilities in J-TEXT Ohmic Plasmas

Quasi-coherent micro-instabilities is one of the key topics of magnetic confinement fusion. This work focuses on the quasi-coherent spectra of ion temperature gradient(ITG) and trapped-electron-mode instabilities using newly developed far-forward collective scattering measurements within ohmic plasmas in the J-TEXT tokamak.The ITG mode is characterized by frequencies ranging from 30 to 100 k Hz and wavenumbers(k_(θρs)) less than 0.3. Beyond a critical plasma density threshold, the ITG mode undergoes a bifurcation, which is marked by a reduction in frequency and an enhancement in amplitude. Concurrently, enhancements in ion energy loss and degradation in confinement are observed. This ground-breaking discovery represents the first instance of direct experimental evidence that establishes a clear link between ITG instability and ion thermal transport.

Regional Brand and High-quality Development of Fruits in Ethnic Areas of the Yangtze River Economic Belt under the Greater Food Approach

Establishing the Greater Food Approach and promoting the Yangtze River Economic Belt s national major regional development strategy can better support and serve the agricultural power and Chinese-style modernization.This paper introduces the characteristics of fruit industry in 16 autonomous prefectures and 47 autonomous counties under the jurisdiction of the Yangtze River Economic Belt.It studies the intellectual property resources of brand marks from the aspects of geographical indications,collective trademarks,certification trademarks,well-known trademarks in China and national design patents,and analyzes the main problems of brand and high-quality development of fruit industry in these ethnic autonomous areas.Finally,it puts forward some strategies,such as improving the protection of intellectual property rights of geographical indications,using intellectual property rights of brand signs,building modern seed industry upgrading project,drawing lessons from the experience of thousand villages demonstration project,ensuring that large-scale poverty does not occur,and building a diversified food supply system.

Thoughts on Pairing Assistance to Tibet for Promoting Agricultural High-quality Development in Southern Tibet from the Perspective of Agricultural Power

In the new era,there is an urgent need to further promote pairing assistance to Tibet,promote the simultaneous construction of a strong agriculture in Tibet and the China's Mainland,and compose a Chinese-style modernization.Southern Tibet,located in the southeastern part of the Tibet Autonomous Region,includes Shannan City and Nyingchi City,is a region assisted by four provincial partners including Hubei Province.This paper introduces the agricultural environment in southern Tibet,studies its agricultural characteristics,and analyzes the main issues of its pairing assistance.Taking forging the strong consciousness of the Chinese national community as the main line,the paper explores strategies for promoting agricultural high-quality development in southern Tibet through pairing assistance to Tibet from the perspective of agricultural power,and proposes some strategies,such as inheriting agricultural cultural heritage,promoting the upgrading of modern seed industry,enhancing the characteristic advantages of highland barley(naked barley)and animal husbandry industries,and developing edible fungi and cold water fish industries.

Promoting High-quality Development of Grain and Oil in Ethnic Areas of the Yangtze River Economic Belt from the Perspective of Agricultural Power

Accelerating the construction of agricultural power,further promoting the high-quality development of the Yangtze River Economic Belt,and better supporting and serving Chinese-style modernization are the key issues at present.This paper first introduces the Yangtze River Economic Belt and its ethnic areas,and studies the characteristics of the grain and oil industry in the ethnic autonomous areas of the economic belt,as well as the current situation of various types of intellectual property resources,such as industrial cultural heritage,scientific and tech-nological innovation,and brand marking intellectual property.Besides,it analyzes the main problems in the high-quality development of grain and oil in the Yangtze River Economic Belt ethnic areas.Finally,it comes up with recommendations,including protecting the intellectual prop-erty rights of cultural heritage in the field of grain and oil,leading the inheritance and development of excellent traditional Chinese culture,use scientific and technological innovation intellectual property rights to promote the innovation-driven development strategy of the grain and oil in-dustry,and providing counterpart assistance to ethnic autonomous areas in the Yangtze River Economic Belt to further promote the high-quality development of the Yangtze River Economic Belt.

Geographical Indication Intellectual Property Protection and Regional Public Brand Construction of Rape Industry in China

As China s largest oil crop,rape occupies a central position in ensuring the safety of China s cooking oil supply.This paper introduced China s rapeseed industry from the rape type,rapeseed production,planting area,national rapeseed production protected area,rape national dominant characteristic industrial clusters,and rapeseed industry,etc.Besides,from the aspects of geographical indication products,geographical indication trademarks,and geographical indications of agricultural products,this paper discussed the intellectual property protection of geographical indications of rape,rapeseed,and rapeseed oil in China.It analyzed the main problems such as the lag in the formulation of relevant standards for geographical indications and the low use of special signs for geographical indications,and finally came up with recommendations including building a public brand of geographical indications and expanding foreign exchanges of geographical indications.

Inheritance,Innovation and High-quality Development of Herbaceous Edible Oils in Hubei Province under the Strategy of Strengthening the Country with Intellectual Property

Only by improving the production capacity of domestic herbal edible oil can China ensure the safety of the supply chain of the important industrial chain of vegetable edible oil in China and practice the big food concept.In addition to rice,maize,and soybean for using as grain and oil,there are eight kinds of herbaceous edible oil crops in Hubei Province,including rape,peanut,sesame,sunflower,perilla(perilla seed),cotton,linen and tiger nut(Cyperus esculentus).This paper studies the main industries of herbaceous edible oil crops and their intellectual property resources in Hubei Province,and analyzes the main problems of its inheritance,innovation and high-quality development under the strategy of strengthening the country with intellectual property.Finally,it proposes the countermeasures of carrying forward and inheriting traditional knowledge and traditional culture,maintaining the biodiversity of crops,strengthening the creation of new plant varieties and breeding patents,and opening up the whole chain of intellectual property rights.

Lycium ruthenicum Murr. treatment attenuates APP_(SWE)/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model

Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer's disease(AD). However, it is unclear whether different mouse models with mitochondrialrelated diseases have similar changes in mitochondrial morphology of the same tissues. Moreover, whether similarities in mitochondrial morphology can be a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria morphology in different tissues of a novel mitochondrial outer membrane protein Slc25a46 knockout mouse and a traditional APP_(SWE)/PS1ΔE9 transgenic mouse were examined using transmission electron microscope(TEM). Both young Slc25a46 knockout mice and aged APP_(SWE)/PS1ΔE9 mice models showed similar mitochondrial damage in cerebellum tissues. The results indicated that different mitochondrial-related diseases shared similar alteration and defects in mitochondrial morphology. Furthermore, Lycium ruthenicum Murr. extract, a bioactive food substance with cognition-improving property, could effectively improve muscle strength and increase body weight in the Slc25a46 knockout mice. These findings suggest that mitochondrial morphology defects in mice models, particularly in the mitochondrial compartment, represent a unified and effective marker for screening and validating natural product-derived functional substances with mitochondrial protective properties. It also holds potential application in mitochondrial-impaired senile neurodegenerative diseases, especially in AD.

氮气钻井岩爆动力学演化机制的数值模拟及岩爆实录特征分析

为了厘清氮气钻井井底岩爆动力学演化机理,应用多物理场耦合分析软件COMSOL Multiphysics 4.3,建立井底逐渐接近裂缝的数值模型,基于致密砂岩岩体内部微裂缝起裂时对应的等效塑性应变为判断标准,分别应用CWFS(cohesion weakening and frictional strengthening)-DP(Drucker-Prager)内聚力弱化摩擦力强度准则、DP强度准则及MC(Mohr-Coulomb)强度准则进行平行数值计算,得出了氮气钻井井底岩爆的动态演化过程。结果表明:井底逐渐靠近裂缝过程中致密砂岩基质会产生两种不同的破坏方式,即是沿着潜在剪切面,向井筒剪切滑移破坏及应力集中条件下的微剪切方式的挤压屈服破坏,直至破坏区延伸连通低压井筒,裂缝内的高压气体及岩爆碎屑释放大量能量,产生井底岩爆。研究成果可系统解释X8-2井井底岩爆发生前后随钻监测参数的异常变化,为准确判断氮气钻井井下工况提供了理论支撑,同时为及时采取针对性的对策措施提供了依据。

基于SWOT分析的矿山生态修复治理EOD模式研究

矿山的生态修复治理已成为亟需解决的生态环境和区域协调发展的关键难题。本文系统分析了政府和社会资本合作模式(Public-Private-Partnership,PPP模式)及工程总承包模式(Engineering-Procurement-Construction,EPC模式)在矿山生态修复治理中的现状,并基于SWOT分析法梳理出生态环境导向的矿山生态修复治理开发模式(Eco-environment-oriented Development,EOD模式)下矿山修复的内在优劣势和外部的机遇与挑战。研究结果表明,EOD模式可以很好地吸纳EPC模式和PPP模式的优点,将矿山修复工作融合到区域经济发展中,EOD模式的优势表现在促进区域融合发展、加速土地指标流转、废弃资源综合利用、经济增长与环境保护相协调、缓解政府治理环境的压力、国家部门政策支持,以及环境治理资金投入不断加大等方面。EOD模式在矿山生态修复治理方面的劣势主要表现为对于区位优势不突出的矿山难以起到很好的融资效果,进而实现经济效益,并且在利益分配方面也面临着尾矿处置权益边界不清晰和国家在生态修复过程中的制度缺陷等问题。

气体钻井高效开发致密砂岩气藏的典型案例分析

目前气体钻井开发致密砂岩气藏是否高效建产受多方面制约,建产机理尚不清晰,阻碍了气体钻井发挥技术优势。为此,文章选取塔里木迪北地区和川西地区的典型高产井为研究对象,在综合分析随钻资料的基础上,探究了高效建产的共性特征。研究发现,产气点的井深与砂泥岩岩性界面存在高度相关性,证实了岩性界面处发育的缝网系统是有利渗流通道;有水致密气藏中,受断裂带影响,地层水在断层下降盘上部富集概率高,部署在断层上升盘的井产水程度低,加之岩性界面缝的存在,使气水实现同产、稳产。分析认为,井位部署应以构造高部位和断层上升盘为依据,确保气源富集的同时避免水体突进,井轨迹应将岩性界面缝作为重点穿越目标,上部井段下套管应避免完全封隔目的层泥岩段,以充分释放岩性界面缝的产气潜力。未来还应加强技术攻关,提升气体钻井钻穿复杂砂泥岩互层的能力。

基于三维地质力学的压力剖面钻前预测研究

为解决目前基于邻井测井资料评价得到的压力剖面与待钻井实际井轨迹上的结果不符等问题,提出基于三维地质力学的待钻井井眼轨迹上的压力剖面钻前预测方法。以地震解释的层位数据为基础,结合断层数据、钻井分层数据等构建三维地质模型。然后,利用已钻井测井数据,通过序贯高斯插值法获得三维岩石力学参数场,并且通过有限元数值模拟得到区域地应力以及压力系统,进而获得待钻井井眼轨迹上的压力剖面。研究结果表明:该方法预测精度较高,已钻井的孔隙压力预测值与实测值的误差为3.57%,地应力预测值与实测值误差为5.8%。现场2口井的预测层位与实钻层位吻合程度较高,预测的三压力剖面能够较好地解释实钻过程中出现的井下复杂问题。研究结果可为钻前地质工程设计、井身结构优化、井下复杂问题预防等提供较为可靠的数据参考。

探究减瘤手术对合并远处转移的上尿路尿路上皮癌患者预后的影响

目的探究减瘤手术对合并远处转移的上尿路尿路上皮癌患者预后的影响。方法筛选2010年1月至2015年12月SEER数据库中已经发生远处转移的上尿路尿路上皮癌患者的临床数据,根据是否行减瘤手术分为减瘤手术组和未做减瘤手术组,比较组间基线差异。通过单因素和多因素Cox比例风险回归模型分析与已经发生远处转移的上尿路尿路上皮癌患者生存有关的预后影响因素。通过Kaplan-Meier法绘制生存曲线分析各组的生存情况。结果本研究共纳入患者238例,减瘤手术者157例,未做减瘤手术者81例,总体基线较为平稳。单因素和多因素Cox回归分析结果显示:减瘤手术、化学药物治疗(以下简称化疗)、肝转移是总生存期(overall survival,OS)的独立风险因素;减瘤手术和化疗是癌症特异性生存期(cancer special survival,CSS)的独立风险因素。Kaplan-Meier曲线显示:年龄、减瘤手术、化疗、肝转移与OS密切相关;减瘤手术、化疗、肝转移与CSS密切相关。结论对于已经发生远处转移的上尿路尿路上皮癌患者,减瘤手术可明显改善患者预后,减瘤手术、化疗、肝转移是总生存结局的独立影响因素,减瘤手术和化疗是疾病相关生存结局的独立影响因素。

Scientific Advances and Weather Services of the China Meteorological Administration’s National Forecasting Systems during the Beijing 2022 Winter Olympics

Since the Beijing 2022 Winter Olympics was the first Winter Olympics in history held in continental winter monsoon climate conditions across complex terrain areas,there is a deficiency of relevant research,operational techniques,and experience.This made providing meteorological services for this event particularly challenging.The China Meteorological Administration(CMA)Earth System Modeling and Prediction Centre,achieved breakthroughs in research on short-and medium-term deterministic and ensemble numerical predictions.Several key technologies crucial for precise winter weather services during the Winter Olympics were developed.A comprehensive framework,known as the Operational System for High-Precision Weather Forecasting for the Winter Olympics,was established.Some of these advancements represent the highest level of capabilities currently available in China.The meteorological service provided to the Beijing 2022 Games also exceeded previous Winter Olympic Games in both variety and quality.This included achievements such as the“100-meter level,minute level”downscaled spatiotemporal resolution and forecasts spanning 1 to 15 days.Around 30 new technologies and over 60 kinds of products that align with the requirements of the Winter Olympics Organizing Committee were developed,and many of these techniques have since been integrated into the CMA’s operational national forecasting systems.These accomplishments were facilitated by a dedicated weather forecasting and research initiative,in conjunction with the preexisting real-time operational forecasting systems of the CMA.This program represents one of the five subprograms of the WMO’s high-impact weather forecasting demonstration project(SMART2022),and continues to play an important role in their Regional Association(RA)II Research Development Project(Hangzhou RDP).Therefore,the research accomplishments and meteorological service experiences from this program will be carried forward into forthcoming highimpact weather forecasting activities.This article provides an overview and assessment of this program and the operational national forecasting systems.

Influence of perinatal factors on full-term low-birth-weight infants and construction of a predictive model

BACKGROUND Being too light at birth can increase the risk of various diseases during infancy.AIM To explore the effect of perinatal factors on term low-birth-weight(LBW)infants and build a predictive model.This model aims to guide the clinical management of pregnant women’s healthcare during pregnancy and support the healthy growth of newborns.METHODS A retrospective analysis was conducted on data from 1794 single full-term pregnant women who gave birth.Newborns were grouped based on birth weight:Those with birth weight<2.5 kg were classified as the low-weight group,and those with birth weight between 2.5 kg and 4 kg were included in the normal group.Multiple logistic regression analysis was used to identify the factors influencing the occurrence of full-term LBW.A risk prediction model was established based on the analysis results.The effectiveness of the model was analyzed using the Hosmer–Leme show test and receiver operating characteristic(ROC)curve to verify the accuracy of the predictions.RESULTS Among the 1794 pregnant women,there were 62 cases of neonatal weight<2.5 kg,resulting in an LBW incidence rate of 3.46%.The factors influencing full-term LBW included low maternal education level[odds ratio(OR)=1.416],fewer prenatal examinations(OR=2.907),insufficient weight gain during pregnancy(OR=3.695),irregular calcium supplementation during pregnancy(OR=1.756),and pregnancy hypertension syndrome(OR=2.192).The prediction model equation was obtained as follows:Logit(P)=0.348×maternal education level+1.067×number of prenatal examinations+1.307×insufficient weight gain during pregnancy+0.563×irregular calcium supplementation during pregnancy+0.785×pregnancy hypertension syndrome−29.164.The area under the ROC curve for this model was 0.853,with a sensitivity of 0.852 and a specificity of 0.821.The Hosmer–Leme show test yieldedχ^(2)=2.185,P=0.449,indicating a good fit.The overall accuracy of the clinical validation model was 81.67%.CONCLUSION The occurrence of full-term LBW is related to maternal education,the number of prenatal examinations,weight gain during pregnancy,calcium supplementation during pregnancy,and pregnancy-induced hypertension.The constructed predictive model can effectively predict the risk of full-term LBW.

Treatment of malignant biliary obstruction by combined percutaneous transhepatic biliary drainage with local tumor treatment

瞄准：为了评估本地肿瘤的用途，治疗为恶意的妨碍的胆汁的疾病把胆汁的排水(PTBD ) 与经皮的 transhepatic 相结合。方法：有恶意的胆汁的阻塞的 233 个病人的一个总数被金属性的 stents 或塑料试管的放置与 PTBD 在我们的医院里对待。在 PTBD 以后， 49 个病人接受了 brachytherapy 或额外放射的治疗或动脉的注入化疗。病人被跟随在上面与临床、 X 光线照相术的评估。幸存和斯滕特氏印模膏明显率被 Kaplan-Meier 幸存分析计算。结果： 22 个病人经历了化疗(肝的癌的 11 个盒子，胰腺的癌的 7 个盒子，变形淋巴结病的 4 个盒子)，并且 14 个病人收到了放射疗法( cholangiocarcinoma 的 10 个盒子，胰腺的癌的 4 个盒子)，并且 13 个病人接受了 brachytherapy ( cholangiocarcinoma 的 7 个盒子，胰腺的癌的 3 个盒子，变形淋巴结病的 4 个盒子)。在 1， 3， 6，和 12 个月的本地肿瘤治疗组的幸存率分别地是 97.96% ， 95.92% ， 89.80% ，和 32.59% ，比的长非治疗组。在 1， 3， 6，和 12 个月的明显率分别地是 97.96% ， 93.86% ， 80.93% ，和 56.52% 。明显率的差别不在治疗组之间是重要的，非，治疗组织。结论：我们的结果建议那本地肿瘤治疗能与恶意的胆汁的阻塞延长病人的生存时间，并且可以改进斯滕特氏印模膏明显。

Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients

BACKGROUND Hepatitis B is a major public health problem in China. Accurate liver injury assessment is essential for clinical evidence-based treatment. Liver biopsy is considered the gold standard method to stage liver disease, but it is not widely used in resource-limited settings. Therefore, non-invasive liquid biopsy tests are needed. AIM To assess liver injury in hepatitis B patients using quantified cell free DNA combined with other serum biomarker as a liquid biopsy-based method. METHODS A cohort of 663 subjects including 313 hepatitis B patients and 350 healthy controls were enrolled. Ultrasound-guided liver biopsies followed by histopathological assessments were performed for the 263 chronic hepatitis B patients to determine the degree of liver injury. Cell-free DNA was quantified using a novel duplex real-time polymerase chain reaction assay. RESULTS Compared with healthy controls, patients with hepatitis B virus (HBV) infection had significantly higher plasma DNA, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and HBV DNA levels (P<0.01). Serum ALT, AST, bilirubin, and plasma DNA levels of patients with markedsevere inflammation were significantly higher than those with mild-moderate inflammation (P<0.01). There was a statistically significant correlation between hepatocyte inflammation severity and serum bilirubin (R^2=0.673, P<0.01) or plasma DNA (R^2=0.597, P<0.01) levels. The areas under the curves of serum ALT, bilirubin, plasma DNA, and their combination to distinguish between patients with mild–moderate and marked-severe inflammation were 0.8059, 0.7910, 0.7921, and 0.9564, respectively. CONCLUSION The combination of plasma DNA, serum ALT, and bilirubin could be a candidate liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients.

砂样岩屑图像特征的岩性智能高效识别

在录井过程中,岩屑的岩性分析主要依靠人工,效率较低且稳定性较差,难以在钻进地层过程中快速识别岩性变化。为此,提出基于砂样图像中颗粒岩屑纹理、色泽和形状等特征的岩性智能识别方法。首先,计算砂样图像的像素值梯度并求取颗粒质心,采用分水岭算法获取颗粒岩屑轮廓线并标记;然后,采用图像分割算法从砂样图像中分离出待检测的单个颗粒岩屑图像,建立颗粒岩屑图像样本库;最后,利用注意力机制及特征融合模块改进MobileNetV2网络,提取颗粒岩屑特征并分类,实现单个颗粒岩屑图像岩性识别,进而获取砂样岩性成分比。该方法将以往岩性智能识别过程中常采用的砂样整体识别方式转变为对砂样中单颗粒岩屑的岩性识别,大幅度减少了颗粒岩屑之间的相互干扰。多个油气区块的砂样图像测试结果表明,该方法对灰岩、泥岩、砂岩和页岩的识别准确率均不低于92%,一组砂样图像岩性分析的用时小于10 s。

油气勘探开发中的工程地质力学问题及研究方法

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