Efficient thermal management of lithium-ion battery,working under extremely rapid charging-discharging,is of widespread interest to avoid the battery degradation due to temperature rise,resulting in the enhanced lifes...Efficient thermal management of lithium-ion battery,working under extremely rapid charging-discharging,is of widespread interest to avoid the battery degradation due to temperature rise,resulting in the enhanced lifespan.Herein,thermal management of lithium-ion battery has been performed via a liquid cooling theoretical model integrated with thermoelectric model of battery packs and single-phase heat transfer.Aiming to alleviate the battery temperature fluctuation by automatically manipulating the flow rate of working fluid,a nominal model-free controller,i.e.,fuzzy logic controller is designed.An optimized on-off controller based on pump speed optimization is introduced to serve as the comparative controller.Thermal control simulations are conducted under regular operating and extreme operating conditions,and two controllers are applied to control battery temperature with proper intervals which is conducive to enhance the battery charge-discharge efficiency.The results indicate that,for any operating condition,the fuzzy logic controller shows excellence in terms of the tracking accuracy of set-point of battery temperature.Thanks to the establishment of fuzzy set and fuzzy behavioral rules,the battery temperature has been throughout maintained near the set point,and the temperature fluctuation amplitude is highly reduced,with better temperature control accuracy of~0.2℃(regular condition)and~0.5℃(extreme condition)compared with~1.1℃(regular condition)and~1.6℃(extreme condition)of optimized on-off controller.While in the case of extreme operating condition,the proposed optimized on-off controller manifests the hysteresis in temperature fluctuation,which is ascribed to the set of dead-band for the feedback temperature.The simulation results cast new light on the utilization and development of model-free temperature controller for the thermal management of lithium-ion battery.展开更多
为提高新能源渗透率、拓宽绿氢生产利用途径、实现综合能源系统多能联供低碳经济化运行,提出包含电制氢(power to hydrogen,P2H)技术的风-氢多元储能系统(wind-hydrogen multi-energy storage,WHMES),建立综合能源系统多目标优化配置模...为提高新能源渗透率、拓宽绿氢生产利用途径、实现综合能源系统多能联供低碳经济化运行,提出包含电制氢(power to hydrogen,P2H)技术的风-氢多元储能系统(wind-hydrogen multi-energy storage,WHMES),建立综合能源系统多目标优化配置模型及两阶段能量梯级利用运行控制策略,将某系统中全年风电及负荷聚合为3类典型场景,以经济、能源供应、碳排放3个方面作为优化目标,采用基于分解的多目标进化算法进行求解,在得到的一系列非劣解集中,利用模糊隶属度函数从中权衡筛选出最优配置方案。算例结果验证了所提模型与方法的科学性与有效性,并在不同典型日场景下都具有良好的环保性和供能可靠性,为含风氢耦合的综合能源系统优化配置提供参考。展开更多
OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on...OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was conducted.The targeted skin lesions were categorized into either the treatment or control group.The treatment group used the flesh-moistening paste;the control group used a placebo.Both the paste and the placebo were topically applied twice daily for eight weeks.The patients were examined biweekly to evaluate the effects.The two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier function.Adverse events were recorded during the study period.SPSS 21.0 was used to analyze the data.RESULTS:Fifty-six patients were enrolled between February 2016 and October 2017.Two were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the study.Four dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse event.The final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion rate.After 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control group.Only one patient had an adverse reaction associated with the treatment.Improvements in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demonstrated a reliable curative effect and safety for treating psoriasis vulgaris in patients with blood stasis patterns.The topical paste improved the barrier function of the skin lesions.展开更多
基金supported by the National Key R&D Program of China(2021YFB3803200)the National Natural Science Foundation of China(Grant No.U2241253)。
文摘Efficient thermal management of lithium-ion battery,working under extremely rapid charging-discharging,is of widespread interest to avoid the battery degradation due to temperature rise,resulting in the enhanced lifespan.Herein,thermal management of lithium-ion battery has been performed via a liquid cooling theoretical model integrated with thermoelectric model of battery packs and single-phase heat transfer.Aiming to alleviate the battery temperature fluctuation by automatically manipulating the flow rate of working fluid,a nominal model-free controller,i.e.,fuzzy logic controller is designed.An optimized on-off controller based on pump speed optimization is introduced to serve as the comparative controller.Thermal control simulations are conducted under regular operating and extreme operating conditions,and two controllers are applied to control battery temperature with proper intervals which is conducive to enhance the battery charge-discharge efficiency.The results indicate that,for any operating condition,the fuzzy logic controller shows excellence in terms of the tracking accuracy of set-point of battery temperature.Thanks to the establishment of fuzzy set and fuzzy behavioral rules,the battery temperature has been throughout maintained near the set point,and the temperature fluctuation amplitude is highly reduced,with better temperature control accuracy of~0.2℃(regular condition)and~0.5℃(extreme condition)compared with~1.1℃(regular condition)and~1.6℃(extreme condition)of optimized on-off controller.While in the case of extreme operating condition,the proposed optimized on-off controller manifests the hysteresis in temperature fluctuation,which is ascribed to the set of dead-band for the feedback temperature.The simulation results cast new light on the utilization and development of model-free temperature controller for the thermal management of lithium-ion battery.
文摘为提高新能源渗透率、拓宽绿氢生产利用途径、实现综合能源系统多能联供低碳经济化运行,提出包含电制氢(power to hydrogen,P2H)技术的风-氢多元储能系统(wind-hydrogen multi-energy storage,WHMES),建立综合能源系统多目标优化配置模型及两阶段能量梯级利用运行控制策略,将某系统中全年风电及负荷聚合为3类典型场景,以经济、能源供应、碳排放3个方面作为优化目标,采用基于分解的多目标进化算法进行求解,在得到的一系列非劣解集中,利用模糊隶属度函数从中权衡筛选出最优配置方案。算例结果验证了所提模型与方法的科学性与有效性,并在不同典型日场景下都具有良好的环保性和供能可靠性,为含风氢耦合的综合能源系统优化配置提供参考。
基金Supported by the Clinical Characteristics Application of Beijing Municipal Science and Technology Commission(No.Z161100000516108)a Randomized Controlled Clinical Study on the Indications of TCM External Treatment for Psoriasis with"Analogic Drug Selection"the Project of Ten Diseases and Ten Drugs funded by the Beijing Municipal Science and Technology Commission(No.Z161100001816024)Research and Development of Traditional Chinese Medicine Preparation for Treatment of Sunburn By Hao Qin Huaban Granule+1 种基金the project supported by the National Natural Science Foundation of China(No.81673975 Study on the Mechanism of Hui Yang Sheng Ji Gao Promoting Ulcer Angiogenesis in Type 2 Diabetes Mellitus and 81774309 Study on the Immune Regulation Mechanism of PI3K/Akt/m TOR Signaling Pathway Mediated by tlrs-4 in Light Sensitive Skin Diseases by Clearing Heat,Cooling Blood and Detoxification)the Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis(No.BZ0375)。
文摘OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was conducted.The targeted skin lesions were categorized into either the treatment or control group.The treatment group used the flesh-moistening paste;the control group used a placebo.Both the paste and the placebo were topically applied twice daily for eight weeks.The patients were examined biweekly to evaluate the effects.The two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier function.Adverse events were recorded during the study period.SPSS 21.0 was used to analyze the data.RESULTS:Fifty-six patients were enrolled between February 2016 and October 2017.Two were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the study.Four dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse event.The final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion rate.After 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control group.Only one patient had an adverse reaction associated with the treatment.Improvements in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demonstrated a reliable curative effect and safety for treating psoriasis vulgaris in patients with blood stasis patterns.The topical paste improved the barrier function of the skin lesions.
