目的分析血清的细胞周期激酶抑制因子4b(INK4b)位点的反义非编码RNA(antisense non-coding RNA in the INK4 Locus,lncRNA ANRIL)、基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)与血清淀粉样蛋白A(serum amyloid protein A,SAA...目的分析血清的细胞周期激酶抑制因子4b(INK4b)位点的反义非编码RNA(antisense non-coding RNA in the INK4 Locus,lncRNA ANRIL)、基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)与血清淀粉样蛋白A(serum amyloid protein A,SAA)在食管癌中的表达及临床意义。方法食管癌病人80例,同期体检健康人群100例。采用实时定量聚合酶链反应(real-time PCR)法检测血清lncRNA ANRIL;采用酶联免疫吸附法(ELISA)和酶法分别检测MMP-2与SAA水平。结果食管癌病人lncRNA ANRIL、MMP-2与SAA水平高于对照组,差异有统计学意义(P<0.05)。食管癌病人lncRNA ANRIL、MMP-2和SAA水平与肿瘤TNM分期、组织学类型、肿瘤分化程度等显著相关(P<0.05),且在中晚期食管癌、食管腺鳞癌及低分化食管癌病人中的增高最为显著。lncRNA ANRIL联合MMP-2与SAA在区分食管癌与对照的曲线下面积(area under the curve,AUC)为0.927(95%CI:0.900~0.954,P<0.05),灵敏度为80.1%,特异度为90.4%。多因素分析显示,高lncRNA ANRIL、MMP-2和SAA水平是食管癌发病的独立危险因素。结论 lncRNA ANRIL、MMP-2和SAA对食管癌具有诊断价值,可作为食管癌发病风险预测的参考指标。展开更多
The research of three-dimensional integrated communication technology plays a key role in achieving the ubiquitous connectivity,ultra-high data rates,and emergency communications in the sixth generation(6G)networks.Ae...The research of three-dimensional integrated communication technology plays a key role in achieving the ubiquitous connectivity,ultra-high data rates,and emergency communications in the sixth generation(6G)networks.Aerial networking provides a prom⁃ising solution to flexible,scalable,low-cost and reliable coverage for wireless devices.The integration of aerial network and terrestrial network has been an inevitable paradigm in the 6G era.However,energy-efficient communications and networking among aerial net⁃work and terrestrial network face great challenges.This paper is dedicated to discussing green communications of the air-ground integrated heterogeneous network(AGIHN).We first provide a brief introduction to the characteristics of AGIHN in 6G networks.Further,we analyze the challenges of green AGIHN from the aspects of green terrestrial networks and green aerial networks.Finally,several solutions to and key technologies of the green AGIHN are discussed.展开更多
文摘目的分析血清的细胞周期激酶抑制因子4b(INK4b)位点的反义非编码RNA(antisense non-coding RNA in the INK4 Locus,lncRNA ANRIL)、基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)与血清淀粉样蛋白A(serum amyloid protein A,SAA)在食管癌中的表达及临床意义。方法食管癌病人80例,同期体检健康人群100例。采用实时定量聚合酶链反应(real-time PCR)法检测血清lncRNA ANRIL;采用酶联免疫吸附法(ELISA)和酶法分别检测MMP-2与SAA水平。结果食管癌病人lncRNA ANRIL、MMP-2与SAA水平高于对照组,差异有统计学意义(P<0.05)。食管癌病人lncRNA ANRIL、MMP-2和SAA水平与肿瘤TNM分期、组织学类型、肿瘤分化程度等显著相关(P<0.05),且在中晚期食管癌、食管腺鳞癌及低分化食管癌病人中的增高最为显著。lncRNA ANRIL联合MMP-2与SAA在区分食管癌与对照的曲线下面积(area under the curve,AUC)为0.927(95%CI:0.900~0.954,P<0.05),灵敏度为80.1%,特异度为90.4%。多因素分析显示,高lncRNA ANRIL、MMP-2和SAA水平是食管癌发病的独立危险因素。结论 lncRNA ANRIL、MMP-2和SAA对食管癌具有诊断价值,可作为食管癌发病风险预测的参考指标。
基金This work was supported by National Natural Science Foundation of Chi⁃na under Grant Nos.61901051 and 61932005.
文摘The research of three-dimensional integrated communication technology plays a key role in achieving the ubiquitous connectivity,ultra-high data rates,and emergency communications in the sixth generation(6G)networks.Aerial networking provides a prom⁃ising solution to flexible,scalable,low-cost and reliable coverage for wireless devices.The integration of aerial network and terrestrial network has been an inevitable paradigm in the 6G era.However,energy-efficient communications and networking among aerial net⁃work and terrestrial network face great challenges.This paper is dedicated to discussing green communications of the air-ground integrated heterogeneous network(AGIHN).We first provide a brief introduction to the characteristics of AGIHN in 6G networks.Further,we analyze the challenges of green AGIHN from the aspects of green terrestrial networks and green aerial networks.Finally,several solutions to and key technologies of the green AGIHN are discussed.
