目的分析近7年大肠埃希菌及肺炎克雷伯菌耐药率与抗菌药物使用强度(antibiotics use density,AUD)的相关性,为临床合理使用抗菌药物提供参考。方法回顾性分析该院2016—2022年大肠埃希菌及肺炎克雷伯菌的耐药率与同期主要抗菌药物的AUD...目的分析近7年大肠埃希菌及肺炎克雷伯菌耐药率与抗菌药物使用强度(antibiotics use density,AUD)的相关性,为临床合理使用抗菌药物提供参考。方法回顾性分析该院2016—2022年大肠埃希菌及肺炎克雷伯菌的耐药率与同期主要抗菌药物的AUD,采用Pearson相关性分析法分析两者的相关性。结果大肠埃希菌对对哌拉西林/他唑巴坦的耐药率与头孢呋辛的AUD呈正相关(P<0.05);对头孢吡肟的耐药率与头孢西丁、氨曲南的AUD呈正相关(P<0.01、P<0.05);对头孢西丁的耐药率与头孢西丁的AUD呈正相关(P<0.05);对亚胺培南的耐药率与头孢哌酮/舒巴坦、阿米卡星的AUD呈正相关(P<0.01)。肺炎克雷伯菌对阿莫西林/克拉维酸的耐药率与头孢西丁、氨曲南的AUD呈正相关(P<0.01);对哌拉西林/他唑巴坦的耐药率与头孢西丁的AUD呈正相关(P<0.05),对头孢噻肟的耐药率与阿莫西林/克拉维酸的AUD呈正相关(P<0.01);对头孢吡肟的耐药率与头孢西丁、左氧氟沙星的AUD呈正相关(P<0.05);对阿米卡星的耐药率与头孢他啶、头孢噻肟、亚胺培南的AUD呈正相关(P<0.01、P<0.05)。大肠埃希菌对哌拉西林/他唑巴坦的耐药率与头孢唑啉的AUD呈负相关(P<0.05);对头孢唑啉的耐药率与头孢他啶、头孢噻肟的AUD呈负相关(P<0.05);对头孢吡肟的耐药率与哌拉西林/他唑巴坦、头孢噻肟的AUD呈负相关(P<0.05);对头孢西丁的耐药率与头孢噻肟的AUD呈负相关(P<0.05);对亚胺培南的耐药率与阿莫西林/克拉维酸的AUD呈负相关(P<0.05)。肺炎克雷伯菌对阿莫西林/克拉维酸的耐药率与哌拉西林/他唑巴坦的AUD呈负相关(P<0.05);对头孢西丁的耐药率与哌拉西林/他唑巴坦的AUD呈负相关(P<0.05)。结论大肠埃希菌及肺炎克雷伯菌的耐药率与多种抗菌药物的AUD相关,应加强抗菌药物的合理管控,延缓细菌耐药的发生。展开更多
The size effects on the crystallite structure,Raman spectra as well as phase tian-sition in lanthanum-modified lead titanate Pb_(1-x)La_(x)Ti_(1-3/4x)O_(3)(x=0.14)(PLT14)nanocrystalline powders were investigated.The r...The size effects on the crystallite structure,Raman spectra as well as phase tian-sition in lanthanum-modified lead titanate Pb_(1-x)La_(x)Ti_(1-3/4x)O_(3)(x=0.14)(PLT14)nanocrystalline powders were investigated.The results show that with decreasing grain size,the crystallite structure changes from tetragonal perovskite phase to cubic perovskite phase;the soft mode frequency at room temperature decreases,and disappears when the grain size is as small as 19nm;the phase transition temperature from ferroelectric to paraelectric shifts towards a low temperature region.The phase transition in nanocrystalline PLT14 is a second order one,which is confirmed by its dielectric constant measurement.展开更多
The Raman spectra of PbZr_(0.3)Ti_(0.7)O_(3) for different grain size as well as at high temperature and high pressure have revealed that its structure is transformed from tetragonal to quasi-cubic phase with decreasi...The Raman spectra of PbZr_(0.3)Ti_(0.7)O_(3) for different grain size as well as at high temperature and high pressure have revealed that its structure is transformed from tetragonal to quasi-cubic phase with decreasing grain size.The phase transition temperature drops down to a lower temperature and the pressure-induced phase transition can be correlated with the diffuse phase transition.展开更多
文摘目的分析近7年大肠埃希菌及肺炎克雷伯菌耐药率与抗菌药物使用强度(antibiotics use density,AUD)的相关性,为临床合理使用抗菌药物提供参考。方法回顾性分析该院2016—2022年大肠埃希菌及肺炎克雷伯菌的耐药率与同期主要抗菌药物的AUD,采用Pearson相关性分析法分析两者的相关性。结果大肠埃希菌对对哌拉西林/他唑巴坦的耐药率与头孢呋辛的AUD呈正相关(P<0.05);对头孢吡肟的耐药率与头孢西丁、氨曲南的AUD呈正相关(P<0.01、P<0.05);对头孢西丁的耐药率与头孢西丁的AUD呈正相关(P<0.05);对亚胺培南的耐药率与头孢哌酮/舒巴坦、阿米卡星的AUD呈正相关(P<0.01)。肺炎克雷伯菌对阿莫西林/克拉维酸的耐药率与头孢西丁、氨曲南的AUD呈正相关(P<0.01);对哌拉西林/他唑巴坦的耐药率与头孢西丁的AUD呈正相关(P<0.05),对头孢噻肟的耐药率与阿莫西林/克拉维酸的AUD呈正相关(P<0.01);对头孢吡肟的耐药率与头孢西丁、左氧氟沙星的AUD呈正相关(P<0.05);对阿米卡星的耐药率与头孢他啶、头孢噻肟、亚胺培南的AUD呈正相关(P<0.01、P<0.05)。大肠埃希菌对哌拉西林/他唑巴坦的耐药率与头孢唑啉的AUD呈负相关(P<0.05);对头孢唑啉的耐药率与头孢他啶、头孢噻肟的AUD呈负相关(P<0.05);对头孢吡肟的耐药率与哌拉西林/他唑巴坦、头孢噻肟的AUD呈负相关(P<0.05);对头孢西丁的耐药率与头孢噻肟的AUD呈负相关(P<0.05);对亚胺培南的耐药率与阿莫西林/克拉维酸的AUD呈负相关(P<0.05)。肺炎克雷伯菌对阿莫西林/克拉维酸的耐药率与哌拉西林/他唑巴坦的AUD呈负相关(P<0.05);对头孢西丁的耐药率与哌拉西林/他唑巴坦的AUD呈负相关(P<0.05)。结论大肠埃希菌及肺炎克雷伯菌的耐药率与多种抗菌药物的AUD相关,应加强抗菌药物的合理管控,延缓细菌耐药的发生。
基金Supported by the National Natural Science Foundation of ChinaDoctorial Foundation of National Committee of Education of China。
文摘The size effects on the crystallite structure,Raman spectra as well as phase tian-sition in lanthanum-modified lead titanate Pb_(1-x)La_(x)Ti_(1-3/4x)O_(3)(x=0.14)(PLT14)nanocrystalline powders were investigated.The results show that with decreasing grain size,the crystallite structure changes from tetragonal perovskite phase to cubic perovskite phase;the soft mode frequency at room temperature decreases,and disappears when the grain size is as small as 19nm;the phase transition temperature from ferroelectric to paraelectric shifts towards a low temperature region.The phase transition in nanocrystalline PLT14 is a second order one,which is confirmed by its dielectric constant measurement.
文摘The Raman spectra of PbZr_(0.3)Ti_(0.7)O_(3) for different grain size as well as at high temperature and high pressure have revealed that its structure is transformed from tetragonal to quasi-cubic phase with decreasing grain size.The phase transition temperature drops down to a lower temperature and the pressure-induced phase transition can be correlated with the diffuse phase transition.
