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智能体Petri网融合的多机器人−多任务协调框架 被引量:6
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作者 李勇 李坤成 +3 位作者 孙柏青 张秋豪 王义娜 杨俊友 《自动化学报》 EI CAS CSCD 北大核心 2021年第8期2029-2049,共21页
为解决异构的服务机器人团队为多位老人服务时的协调问题以及在此过程中如何最大化老人的总体满意度,提出了一种服务于多人的多机器人−多任务协调框架.首先,结合时延Petri网和颜色Petri网提出了可扩展时延−颜色Petri网(Scalable timed-c... 为解决异构的服务机器人团队为多位老人服务时的协调问题以及在此过程中如何最大化老人的总体满意度,提出了一种服务于多人的多机器人−多任务协调框架.首先,结合时延Petri网和颜色Petri网提出了可扩展时延−颜色Petri网(Scalable timed-colored Petri net,STdCPN)对养老院情境下服务机器人照顾老人的过程进行建模.然后,将老人的感受和情绪作为机器人照顾老人时的重要指标,构建了服务对象满意度模型.最后,设计智能体来实现该协调框架的调度,该智能体通过考虑老人“个人因素”和机器人的实时状态、位置等信息来对任务进行合理的规划调度,使机器人帮助老人完成任务的同时,最大化老人总体满意度. 展开更多
关键词 多机器人协调 满意度 PETRI 智能体
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阿尔茨海默病针刺四关穴动脉自旋脑灌注初步研究 被引量:6
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作者 马天 樊响 +3 位作者 倪虹 李晖 李坤成 China-ADNI 《阿尔茨海默病及相关病杂志》 2018年第1期1-5,共5页
目的:应用三维动脉自旋标记技术探索阿尔茨海默病针刺四关穴脑血流灌注变化,初步评价针刺四关穴的治疗效果。材料与方法:搜集10例经首都医科大学宣武医院神经内科记忆障碍门诊诊断的AD患者(AD组)和10例年龄、性别和受教育程度与之相匹... 目的:应用三维动脉自旋标记技术探索阿尔茨海默病针刺四关穴脑血流灌注变化,初步评价针刺四关穴的治疗效果。材料与方法:搜集10例经首都医科大学宣武医院神经内科记忆障碍门诊诊断的AD患者(AD组)和10例年龄、性别和受教育程度与之相匹配的正常老年人作为对照(NC组),其中AD组患者行针刺四关穴治疗6个月。采用三维动脉自旋标记(three-dimensional arterial spin labeling,3D-ASL)技术测量被试者脑多部位灌注信号强度,运用神经心理学量表辅助评估AD组及NC组的认知状态。AD组和NC组在入组时和6个月后完成MRI扫描和神经心理学量表测评,分析两组被试的异同。结果:(1)AD组和NC组被试年龄、性别、受教育年限匹配,组间差异无统计学意义(P>0.05); AD组简明精神状态检查量表(mini-mental state examination, MMSE)和蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评分值显著低于NC组。(2)AD组和NC组被试基线数据左右侧脑灌注信号强度差异无统计学意义;AD组在双侧海马、双侧后扣带回、双侧额颞叶皮层、右侧枕叶皮层部位ASL信号强度降低,以右侧后扣带回为著。(3)AD组基线与6个月后复查ASL图像比较,左颞叶皮层、右侧尾状核信号强度减低,差异有统计学意义;NC组基线与6个月复查比较信号强度无显著性差异;AD和NC组二次检查脑灌注ASL的信号差异无统计学意义。结论:(1)应用3D-ASL技术可以显示AD脑灌注异常区,有可能作为AD早期诊断的指标之一。(2)针刺四关穴或可减缓AD脑灌注减低进程。 展开更多
关键词 阿尔茨海默病 三维动脉自旋标记 针刺
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桃红四物汤对缺糖缺氧大鼠脑微血管内皮细胞VEGF、VEGFR-2、Akt基因及蛋白表达的作用机制研究
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作者 郭少英 闫建军 +4 位作者 李媛 娄重章 乔磊 李昆城 王静 《现代生物医学进展》 CAS 2024年第4期636-640,共5页
目的:探讨桃红四物汤对缺糖缺氧(OGD)大鼠脑微血管内皮细胞(r BMECs)血管内皮生长因子(VEGF)、血管内皮生长因子受体2(VEGFR-2)、蛋白激酶B(Akt)基因及蛋白表达的影响及其作用机制。方法:取r BMECs进行培养并随机分为正常组培养、模型... 目的:探讨桃红四物汤对缺糖缺氧(OGD)大鼠脑微血管内皮细胞(r BMECs)血管内皮生长因子(VEGF)、血管内皮生长因子受体2(VEGFR-2)、蛋白激酶B(Akt)基因及蛋白表达的影响及其作用机制。方法:取r BMECs进行培养并随机分为正常组培养、模型组培养、桃红四物汤(0.4 mg/mL)组和桃红四物汤(0.8 mg/mL)组,除正常组外,其余三组采用氧糖剥夺实验构建OGD损伤模型。桃红四物汤组在造模前1 h按0.4 mg/mL、0.8 mg/mL浓度加入桃红四物汤,而正常组及模型组则加入等量体积生理盐水。实时定量聚合酶链反应(qRT-PCR)、蛋白免疫印迹试验检测VEGF、VEGFR-2、Akt基因及蛋白表达情况。结果:与正常组比较,模型组细胞凋亡率显著升高(P<0.05)。与模型组比较,桃红四物汤(0.4 mg/mL)组和桃红四物汤(0.8 mg/mL)组均降低,且以桃红四物汤(0.8 mg/mL)组最为显著(P<0.05)。与正常组比较,模型组r BMECs中Akt、VEGFR-2、VEGF相对m RNA和蛋白表达水平显著升高(P<0.05)。与模型组比较,桃红四物汤(0.4 mg/mL)组和桃红四物汤(0.8 mg/mL)组显著降低,且以桃红四物汤(0.8 mg/mL)组最为显著(P<0.05)。结论:桃红四物汤可能通过降低OGD条件下r BMECs中VEGF、VEGFR-2、Akt基因及蛋白表达水平,从而发挥抑制内皮细胞的凋亡,保持内皮细胞的完整性,这可能是桃红四物汤对脑保护的机制之一。 展开更多
关键词 桃红四物汤 缺糖缺氧 大鼠 脑微血管内皮细胞 VEGF VEGFR-2 Akt
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Dysembryoplastic neuroepithelial tumors: magnetic resonance imaging and magnetic resonance spectroscopy evaluation 被引量:9
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作者 YU Ai-hong CHEN li +3 位作者 li Yong-jie ZHANG Guo-jun li kun-cheng WANG Yu-ping 《Chinese Medical Journal》 SCIE CAS CSCD 2009年第20期2433-2437,共5页
Background Dysembryoplastic neuroepithelial tumor (DNT) is a rare benign neoplasm of the central nervous system affecting young people. A correct preoperative diagnosis is helpful for planning surgical strategies an... Background Dysembryoplastic neuroepithelial tumor (DNT) is a rare benign neoplasm of the central nervous system affecting young people. A correct preoperative diagnosis is helpful for planning surgical strategies and improving prognosis. The purpose of this study was to characterize DNTs using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) and to analyze the value of these two techniques in the diagnosis of DNTs. Methods MR images of 13 patients with DNTs were reviewed retrospectively; and five of the patients also underwent MRS. Tumors were confirmed by surgery. The distribution, extension and signal features of the lesions were assessed, and the MRS results were analyzed. Results All tumors were supratentorial. The cortex was the main area involved, with nine tumors located in the temporal lobe, three in the frontal lobe, and one on the boundary between the temporal and occipital lobes. All cases had decreased signal intensity on Tl-weighted MR images and increased signal intensity on T2-weighted images. On fluid attenuated inversion recovery weighted images, the hyperintense "ring sign" and internal septation of the lesion were seen in 9 cases. Eight tumors had well-demarcated borders. Peritumoral edema or mass effect was absent in all cases. A contrast enhancement examination was performed in 9 cases. Contrast enhancement was absent in five cases, and four cases showed significant enhancement. The MRS showed a low N-acetylaspartate peak and a lack of elevated choline-containing component (Cho) or Cho-Cr ratio (Cho/Cr) in five patients. Conclusions The MRI findings of DNTs were stereotypical. The combination of MRI and MRS techniques were helpful in making a correct presurgical diagnosis. 展开更多
关键词 EPILEPSY dysembryoplastic neuroepithelial tumor magnetic resonance imaging magnetic resonance spectroscopy
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Intracranial malignant meningioma with cerebrospinal fluid dissemination: a case report 被引量:2
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作者 PENG Jing liANG Zhi-gang li kun-cheng 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第10期1597-1599,共3页
Malignant meningiomas are uncommon intracranial tumors. The metastasis of malignant meningiomas to distant extracranial sites are well known. However, dissemination of the tumours in the cerebrospinal fluid (CSF) is... Malignant meningiomas are uncommon intracranial tumors. The metastasis of malignant meningiomas to distant extracranial sites are well known. However, dissemination of the tumours in the cerebrospinal fluid (CSF) is rare and few cases have been reported. We present a case of histologically proven malignant meningioma with CSF dissemination at the remote intracranial area and into the spinal canal detected with maqnetic resonance imaging. 展开更多
关键词 malignant meningioma magnetic resonance imaging cerebrospinal fluid METASTASIS LEPTOMENINGEAL
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Lipid signal in evaluation of intracranial meningiomas
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作者 QI Zhi-gang li Yu-xin +4 位作者 WANG Yan GENG Dao-yin li kun-cheng SHEN Tian-zhen CHEN Xin-rong 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第23期2415-2419,共5页
Background Using magnetic resonance imaging, diagnosis of malignant meningioma from benign meningioma with atypical features is uncertain. We evaluated the value of lipid signal in differentiating intracranial meningi... Background Using magnetic resonance imaging, diagnosis of malignant meningioma from benign meningioma with atypical features is uncertain. We evaluated the value of lipid signal in differentiating intracranial meningiomas. Methods ^1H-magnetic resonance spectroscopy (MRS) using a point resolved spectroscopy (TR/TE 1000/144 ms) sequences were performed on 34 patients on a 3.0 T scanner. Lipid peak located at 1.3 ppm was evaluated. MRS data from these tumours were compared with histopathological findings (including hematoxylin and eosin staining and KP-1 staining). Results Twenty-nine meningiomas were histologically benign (eleven meningothelial, thirteen fibrous, four transitional and one microcystic), three were atypical, and two were anaplastic. Lipid signal was detected in ten cases: two anaplastic three atypical, two fibrous and three rneningothelial meningiomas. All voxels with lipid peak in the spectrum from the tumour were evaluated. With creatinine peak in the normal white matter chosen as internal standard, lipid/creatinine ratios of anaplastic, atypical and benign meningiomas were 0.844±0.027 (range from 0.725 to 0.994), 0.465±0.023 (range from 0.239 to 0.724), and 0.373±0.016 (range from 0.172 to 0.571) respectively. Highly significant differences were noted between anaplastic and the other two subtypes. Patchy necrosis was observed in anaplastic meningioma, while focal necrosis was noted in atypical meningioma with HE stain. However, no necrosis was found in benign group. KP-1 stain demonstrated histocytes containing lipids in the necrotic region of anaplastic and atypical meningioma. Conclusion The lipid signal at 1.3 ppm is a useful marker in evaluating the malignancy of intracranial meningiomas, especially in the differential diagnosis of anaplastic meningioma. 展开更多
关键词 MENINGIOMA magnetic resonance spectroscopy LIPID DIAGNOSIS
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Diffusion tensor imaging in medial temporal lobe epilepsy 被引量:10
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作者 YU Ai-hong li kun-cheng +2 位作者 YU Chun-shui WANG Yu-ping XUE Su-fang 《Chinese Medical Journal》 SCIE CAS CSCD 2006年第15期1237-1241,共5页
Background Diffusion tensor imaging (DTI) is a noninvasive imaging technique for the assessment of the integrity of cerebral tissues. This study was undertaken to assess the changes of diffusion indices of hippocamp... Background Diffusion tensor imaging (DTI) is a noninvasive imaging technique for the assessment of the integrity of cerebral tissues. This study was undertaken to assess the changes of diffusion indices of hippocampal formation (HF) in patients with medial temporal lobe epilepsy (MTLE). Methods Fourteen patients with MTLE and 14 healthy subjects were evaluated. Mean diffusivity (MD) and fractional anisotropy (FA) from the symmetrical-voxel sampling regions of the anterior HF were calculated in all subjects. The MD and FA values were compared across the groups. Results No significant differences of MD and FA values were noted between right and left HF in the controls. In the patient group, MD significantly increased in the HF ipsilateral to the lesioned side [(9.27±1.09)×10^-4 mm^2/s], compared with the values in the contralateral HF [(8.20±0.59)×10^-4 min^2]s] (t = 4.479, P = 0.001) and healthy subjects [(7.58±0.51)×10^-4 mm^2/s] (P 〈 0.001), but no significant differences were found in FA. When compared with the controls, patients had a significantly higher MD in the contralateral HF (P 〈 0.05), but the difference in FA was not statistically significant. Conclusions DTI could detect hippocampal abnormality in patients with MTLE. This technique may be helpful for preoperative evaluation of such patients. 展开更多
关键词 diffusion tensor imaging EPILEPSY temporal lobe
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