A statistical thermodynamic theory of linear protein solutions was proposed with the aid of a lattice model and applied to type Ⅰ antifreeze protein(AFPI) solutions.The numerical results for several AFPI solutions ...A statistical thermodynamic theory of linear protein solutions was proposed with the aid of a lattice model and applied to type Ⅰ antifreeze protein(AFPI) solutions.The numerical results for several AFPI solutions show that the Gibbs function of the solution has a minimum at a certain protein concentration,but the protein chemical potential increases with increasing the concentration.The influences of temperature and protein chain length on the AFPI chemical potential were also discussed.The evaluation for the colligative depression of the freezing point confirms that the antifreeze action should be recognized as non-colligative.The theoretical deduction for the concentration dependence of the thermal hysteresis activity coincides qualitatively with the previous experimental and theoretical results.展开更多
目的探讨超声检查对老年退行性心脏瓣膜病与颈动脉粥样硬化关系的评价价值。方法选择2016年7月至2018年7月间佛山市第五人民医院诊治的150例退行性心脏瓣膜病患者纳入观察组,另选择30例健康志愿者为对照组,比较对照组与不同心脏瓣膜钙...目的探讨超声检查对老年退行性心脏瓣膜病与颈动脉粥样硬化关系的评价价值。方法选择2016年7月至2018年7月间佛山市第五人民医院诊治的150例退行性心脏瓣膜病患者纳入观察组,另选择30例健康志愿者为对照组,比较对照组与不同心脏瓣膜钙化程度分级患者心功能指标、颈动脉硬化情况的差异。根据有无心脏形态改变对观察组患者进行分组,比较两组患者颈动脉硬化情况。结果随着心脏瓣膜钙化分级的增加,观察组中1级、2级及3级患者左室舒张末内径(LVD)[(43.86±4.28) mm vs (50.35±5.86) mm vs (56.37±6.72) mm]、左房内径(LAD)[(33.24±4.83) mm vs (42.25±4.98) mm vs (49.68±5.37) mm]逐渐增大,左室射血分数(LVEF)[(69.28±9.25)%vs (60.32±7.65)%vs (51.98±6.25)%]逐渐降低,不同分级间两两比较差异均有统计学意义(P<0.05);2级及3级患者LVD、LAD及LVEF与对照组[(41.23±4.66) mm,(31.25±4.28) mm,(71.32±9.25) mm]比较差异均有统计学意义(P<0.05);随着心脏瓣膜钙化分级的增加,观察组1级、2级及3级患者颈动脉内膜厚度(IMT)逐渐增大[(1.09±0.36)mm vs (1.22±0.40) mm vs (1.28±0.43) mm],颈动脉斑块积分[(1.66±0.48)分vs (2.43±0.82)分vs (2.88±0.96分)]逐渐增高,不同分级间两两比较差异均有统计学意义(P<0.05);2级及3级患者IMT及颈动脉斑块积分与对照组[(1.06±0.33) mm,(1.62±0.50)分]比较差异均有统计学意义(P<0.05);与无心脏形态改变患者比较,存在心脏形态改变患者的IMT更大[(1.26±0.46) mm vs(1.19±0.32) mm],颈动脉斑块积分更高[(1.96±0.55)分vs (2.62±0.78)分],差异均有统计学意义(P<0.05)。结论超声检查能够准确评价老年退行性心脏瓣膜病及颈动脉粥样硬化的关系,随着老年退行性心脏瓣膜病病情的加重,患者颈动脉硬化程度也加重。展开更多
基金Supported by the National Natural Science Foundation of China(Nos.10764003,30560039)the Special Fund for Basic Scientific Research of Central Colleges,North China Institute of Science and Technology for Nationalities(No.JCB1201A)
文摘A statistical thermodynamic theory of linear protein solutions was proposed with the aid of a lattice model and applied to type Ⅰ antifreeze protein(AFPI) solutions.The numerical results for several AFPI solutions show that the Gibbs function of the solution has a minimum at a certain protein concentration,but the protein chemical potential increases with increasing the concentration.The influences of temperature and protein chain length on the AFPI chemical potential were also discussed.The evaluation for the colligative depression of the freezing point confirms that the antifreeze action should be recognized as non-colligative.The theoretical deduction for the concentration dependence of the thermal hysteresis activity coincides qualitatively with the previous experimental and theoretical results.
文摘目的探讨超声检查对老年退行性心脏瓣膜病与颈动脉粥样硬化关系的评价价值。方法选择2016年7月至2018年7月间佛山市第五人民医院诊治的150例退行性心脏瓣膜病患者纳入观察组,另选择30例健康志愿者为对照组,比较对照组与不同心脏瓣膜钙化程度分级患者心功能指标、颈动脉硬化情况的差异。根据有无心脏形态改变对观察组患者进行分组,比较两组患者颈动脉硬化情况。结果随着心脏瓣膜钙化分级的增加,观察组中1级、2级及3级患者左室舒张末内径(LVD)[(43.86±4.28) mm vs (50.35±5.86) mm vs (56.37±6.72) mm]、左房内径(LAD)[(33.24±4.83) mm vs (42.25±4.98) mm vs (49.68±5.37) mm]逐渐增大,左室射血分数(LVEF)[(69.28±9.25)%vs (60.32±7.65)%vs (51.98±6.25)%]逐渐降低,不同分级间两两比较差异均有统计学意义(P<0.05);2级及3级患者LVD、LAD及LVEF与对照组[(41.23±4.66) mm,(31.25±4.28) mm,(71.32±9.25) mm]比较差异均有统计学意义(P<0.05);随着心脏瓣膜钙化分级的增加,观察组1级、2级及3级患者颈动脉内膜厚度(IMT)逐渐增大[(1.09±0.36)mm vs (1.22±0.40) mm vs (1.28±0.43) mm],颈动脉斑块积分[(1.66±0.48)分vs (2.43±0.82)分vs (2.88±0.96分)]逐渐增高,不同分级间两两比较差异均有统计学意义(P<0.05);2级及3级患者IMT及颈动脉斑块积分与对照组[(1.06±0.33) mm,(1.62±0.50)分]比较差异均有统计学意义(P<0.05);与无心脏形态改变患者比较,存在心脏形态改变患者的IMT更大[(1.26±0.46) mm vs(1.19±0.32) mm],颈动脉斑块积分更高[(1.96±0.55)分vs (2.62±0.78)分],差异均有统计学意义(P<0.05)。结论超声检查能够准确评价老年退行性心脏瓣膜病及颈动脉粥样硬化的关系,随着老年退行性心脏瓣膜病病情的加重,患者颈动脉硬化程度也加重。