Diabetic nephropathy(DN)is the most serious microvascular complication of diabetes mellitus,which is highly prevalent worldwide.Abnormal activation of Wnt/β-catenin signaling pathway is an important mechanism of rena...Diabetic nephropathy(DN)is the most serious microvascular complication of diabetes mellitus,which is highly prevalent worldwide.Abnormal activation of Wnt/β-catenin signaling pathway is an important mechanism of renal damage induced by hyperglycemia.Many studies have shown that TCM has the advantages of high efficiency and safety in the prevention and treatment of DN.Some TCM monomers and compounds repair podocyte function and inhibit transdifferentiation process by inhibiting the activation of Wnt/β-catenin signaling pathway,thus playing a protective role in kidney.Based on this,this paper will review the existing research results and related mechanisms of TCM intervention in Wnt/β-catenin signaling pathway in the treatment of DN,in order to promote the more effective and reasonable application of TCM in clinical practice.展开更多
利用CiteSpace和VOSviewer软件对2012年~2022年Web of Science核心数据库和中国知网中相关的3537篇文献进行计量和可视化分析。美国、中国、德国等是相对高产的国家。国外研究热点集中在中西医结合疗法、癌症护理及整合医学循证系统评价...利用CiteSpace和VOSviewer软件对2012年~2022年Web of Science核心数据库和中国知网中相关的3537篇文献进行计量和可视化分析。美国、中国、德国等是相对高产的国家。国外研究热点集中在中西医结合疗法、癌症护理及整合医学循证系统评价等,未来研究趋势集中在综合肿瘤学、新型冠状病毒感染等。国内研究热点集中在医学教育、教学课程整合与思政教育等,未来研究方向集中在课程体系构建、教学模式改革及复合型医学人才培养等。整合医学是新时代医学研究的必经之路。完善理论体系、加强整合式临床诊治实践和深化整合医学教育课程改革,是我国整合医学发展的关键。展开更多
基金National Natural Science Foundation Project (No.81860838)Guangxi Natural Science Foundation Project (No.GXNSFAA297246)。
文摘Diabetic nephropathy(DN)is the most serious microvascular complication of diabetes mellitus,which is highly prevalent worldwide.Abnormal activation of Wnt/β-catenin signaling pathway is an important mechanism of renal damage induced by hyperglycemia.Many studies have shown that TCM has the advantages of high efficiency and safety in the prevention and treatment of DN.Some TCM monomers and compounds repair podocyte function and inhibit transdifferentiation process by inhibiting the activation of Wnt/β-catenin signaling pathway,thus playing a protective role in kidney.Based on this,this paper will review the existing research results and related mechanisms of TCM intervention in Wnt/β-catenin signaling pathway in the treatment of DN,in order to promote the more effective and reasonable application of TCM in clinical practice.
文摘利用CiteSpace和VOSviewer软件对2012年~2022年Web of Science核心数据库和中国知网中相关的3537篇文献进行计量和可视化分析。美国、中国、德国等是相对高产的国家。国外研究热点集中在中西医结合疗法、癌症护理及整合医学循证系统评价等,未来研究趋势集中在综合肿瘤学、新型冠状病毒感染等。国内研究热点集中在医学教育、教学课程整合与思政教育等,未来研究方向集中在课程体系构建、教学模式改革及复合型医学人才培养等。整合医学是新时代医学研究的必经之路。完善理论体系、加强整合式临床诊治实践和深化整合医学教育课程改革,是我国整合医学发展的关键。