Objective:To systemically evaluate clinical efficacy and safety of traditional Chinese medicine(TCM)combined with ivabradine(IVA)in the treatment of chronic heart failure(CHF).Method:We searched China National Knowled...Objective:To systemically evaluate clinical efficacy and safety of traditional Chinese medicine(TCM)combined with ivabradine(IVA)in the treatment of chronic heart failure(CHF).Method:We searched China National Knowledge Infrastructure(CNKI)datebase,Wanfang datebase,Chinese Scientifific Journal Database(VIP)datebase,PubMed,Conchrane Library and EMbase database to enroll the random control trials(RCTs)of TCM combined with IVA treating CHF.Meta-analysis was performed by Review Manager 5.3 software.Results:A total of 10 RCTs involving 960 patients were included.The results of Meta-analysis showed that compared with control group,the experimental group could improve the efficiency of cardiac function improvement[RR=1.19,95%CI(1.12,1.27),P<0.00001],increase left ventricular ejection fraction[MD=4.36,95%CI(2.88,5.83),P<0.0001]and reduce heart rate[MD=-8.21,95%CI(-12.08,-4.34),P<0.00001],the incidence of adverse reactions was similar between two groups[RR=1.00,95%CI(0.62,1.61),P=1.00].Conclusion:Traditional Chinese medicine combined with ivabradine has significant efficacy and good safety in improving cardiac function,improving left ventricular ejection fraction and reducing heart rate in the treatment of chronic heart failure.展开更多
financially supported by the Key R＆D Program of Jiangxi Province of China （20152ACF60010）;the Key Projects of Hunan Science and Technology Support Program of China （Application research of Guiye A male sterile lin...financially supported by the Key R＆D Program of Jiangxi Province of China （20152ACF60010）;the Key Projects of Hunan Science and Technology Support Program of China （Application research of Guiye A male sterile line）;the Research Project of Humanities and Social Sciences in Universities of Jiangxi Province, China（JC1315）;supported by Emmy Noether DFG grant MA 6473/1-1展开更多
气化炉产生的高温烟气进入激冷室后需要实现快速降温,为了研究这一复杂过程,分别采用Volume of Fluid(VOF)模型、Two-fluid model(TFM)模型和Mixture模型对激冷室下降管内小孔喷淋实验进行数值模拟。由于高温烟气与冷却水接触充分,采用...气化炉产生的高温烟气进入激冷室后需要实现快速降温,为了研究这一复杂过程,分别采用Volume of Fluid(VOF)模型、Two-fluid model(TFM)模型和Mixture模型对激冷室下降管内小孔喷淋实验进行数值模拟。由于高温烟气与冷却水接触充分,采用Lee传质模型描述气液间的传质过程,从而对激冷室内温度测量值和预测值进行对比分析。模拟结果表明:VOF模型预测的温度分布较其他两个模型更合理,另外辐射模型的耦合对温度的预测值基本没有影响,说明在该工况下对流传热是影响激冷效果的主要因素。展开更多
基金National 12th Five-Year Science and Technology Support Plan(No.2013BAI02B01)National Key Science and Technology Project of"Major New Drug Creation"(No.2019ZX09201005-002-006)+1 种基金Beijing TCM Science and Technology Development Fund Project(No.JJ-2020-79)Science and Technology Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A00920)。
文摘Objective:To systemically evaluate clinical efficacy and safety of traditional Chinese medicine(TCM)combined with ivabradine(IVA)in the treatment of chronic heart failure(CHF).Method:We searched China National Knowledge Infrastructure(CNKI)datebase,Wanfang datebase,Chinese Scientifific Journal Database(VIP)datebase,PubMed,Conchrane Library and EMbase database to enroll the random control trials(RCTs)of TCM combined with IVA treating CHF.Meta-analysis was performed by Review Manager 5.3 software.Results:A total of 10 RCTs involving 960 patients were included.The results of Meta-analysis showed that compared with control group,the experimental group could improve the efficiency of cardiac function improvement[RR=1.19,95%CI(1.12,1.27),P<0.00001],increase left ventricular ejection fraction[MD=4.36,95%CI(2.88,5.83),P<0.0001]and reduce heart rate[MD=-8.21,95%CI(-12.08,-4.34),P<0.00001],the incidence of adverse reactions was similar between two groups[RR=1.00,95%CI(0.62,1.61),P=1.00].Conclusion:Traditional Chinese medicine combined with ivabradine has significant efficacy and good safety in improving cardiac function,improving left ventricular ejection fraction and reducing heart rate in the treatment of chronic heart failure.
基金financially supported by the Key R&D Program of Jiangxi Province of China (20152ACF60010)the Key Projects of Hunan Science and Technology Support Program of China (Application research of Guiye A male sterile line)+1 种基金the Research Project of Humanities and Social Sciences in Universities of Jiangxi Province, China(JC1315)supported by Emmy Noether DFG grant MA 6473/1-1
文摘financially supported by the Key R＆D Program of Jiangxi Province of China （20152ACF60010）;the Key Projects of Hunan Science and Technology Support Program of China （Application research of Guiye A male sterile line）;the Research Project of Humanities and Social Sciences in Universities of Jiangxi Province, China（JC1315）;supported by Emmy Noether DFG grant MA 6473/1-1
文摘气化炉产生的高温烟气进入激冷室后需要实现快速降温,为了研究这一复杂过程,分别采用Volume of Fluid(VOF)模型、Two-fluid model(TFM)模型和Mixture模型对激冷室下降管内小孔喷淋实验进行数值模拟。由于高温烟气与冷却水接触充分,采用Lee传质模型描述气液间的传质过程,从而对激冷室内温度测量值和预测值进行对比分析。模拟结果表明:VOF模型预测的温度分布较其他两个模型更合理,另外辐射模型的耦合对温度的预测值基本没有影响,说明在该工况下对流传热是影响激冷效果的主要因素。
