目的:分析化学发光微粒子免疫法(Chemiluminescence particle immunoassay,CMIA)和酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)对乙型肝炎病毒(Hepatitis B virus,HBV)感染患者血清学标志物诊断准确率的临床应用价值.方法...目的:分析化学发光微粒子免疫法(Chemiluminescence particle immunoassay,CMIA)和酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)对乙型肝炎病毒(Hepatitis B virus,HBV)感染患者血清学标志物诊断准确率的临床应用价值.方法:回顾性选取我院2020年5月至2022年4月就诊的85例HBV感染患者,并采用CMIA法、ELISA法分析HBV感染的准确率、血清学标志物检测结果[乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)、乙肝e抗体(Hepatitis B e antibody,HBeAb)、乙肝e抗原(Hepatitis B e antigen,HBeAg)、乙肝核心抗体(Hepatitis B core antibody,HBcAb)浓度]、HBsAb、HBsAg回收率.结果:CMIA法诊断准确率,检测HBsAg、HBeAb、HBcAb阳性率高于ELISA法(P<0.05);两组平均回收率无统计学差异.结论:与ELISA法相比,CMIA法用于检测HBV感染患者血清学标志物具有较高准确度、回收率.展开更多
The poor thermal stability and high sensitivity severely hinder the practical application of hexanitrohexaazaisowurtzitane(CL-20).Herein,a kind of novel core@double-shell CL-20 based energetic composites were fabricat...The poor thermal stability and high sensitivity severely hinder the practical application of hexanitrohexaazaisowurtzitane(CL-20).Herein,a kind of novel core@double-shell CL-20 based energetic composites were fabricated to address the above issues.The coordination complexes which consist of natural polyphenol tannic acid(TA) and Fe~Ⅲ were chosen to construct the inner shell,while the graphene sheets were used to build the outer shell.The resulting CL-20/TA-Fe~Ⅲ/graphene composites exhibited simultaneously improved thermal stability and safety performance with only 1 wt% double-shell content,which should be ascribed to the intense physical encapsulation effect from inner shell combined with the desensitization effect of carbon nano-materials from outer shell.The phase transition(ε to γ) temperature increased from 173.70 ℃ of pure CL-20 to 191.87℃ of CL-20/TA-Fe~Ⅲ/graphene composites.Meanwhile,the characteristic drop height(H_(50)) dramatically increased from 14.7 cm of pure CL-20 to112.8 cm of CL-20/TA-Fe~Ⅲ/graphene composites,indicating much superior safety performance after the construction of the double-shell structure.In general,this work has provided an effective and versatile strategy to conquer the thermal stability and safety issues of CL-20 and contributes to the future application of high energy density energetic materials.展开更多
井下斜坡道的定位与建图是实现井下斜坡道无人驾驶的关键技术之一,矿山井下斜坡道区域为典型非结构化环境特征,且道路具有一定倾斜角度,采用传统SLAM算法无法获得精确里程计信息,导致定位与建图精度难以满足无人矿卡行驶需求。针对上述...井下斜坡道的定位与建图是实现井下斜坡道无人驾驶的关键技术之一,矿山井下斜坡道区域为典型非结构化环境特征,且道路具有一定倾斜角度,采用传统SLAM算法无法获得精确里程计信息,导致定位与建图精度难以满足无人矿卡行驶需求。针对上述问题,通过研究激光SLAM(Simultaneous Localization And Mapping)算法LeGO-LOAM,笔者提出一种适用于矿山井下斜坡道环境的定位与建图方法。首先,针对井下斜坡道口两侧均为光滑水泥墙壁,特征点稀少问题,设计了基于人工路标的辅助增强定位方法,有效增加点云特征数量,从而优化位姿估计结果,避免建图漂移现象;然后在特征预处理阶段,提出了一种基于激光点云高度差与坡度信息融合的提取地面点高效算法,通过改善地面地点的选取策略,针对倾斜坑洼路面仍能有效识别地面点,解决了井下斜坡道定位与建图倾斜角度大、误差大等问题;其次,基于CVC(Curved-Voxel Clustering)聚类算法设计了一种斜坡道点云曲率体素聚类算法,采用曲率体素和基于哈希的数据结构对点云进行分割,大幅提高在井下稀疏、噪声环境下点云聚类的鲁棒性;最后,运用Scan-To-Map进行点云匹配,同时兼顾点云配准的性能与速度。在中钢集团山东某井下斜坡道的现场实验证明:与原算法相比精度提升13.15%,Z轴误差降低22.3%,地图质量明显提升,能有效解决井下无人驾驶建图及定位的难题。展开更多
文摘目的:分析化学发光微粒子免疫法(Chemiluminescence particle immunoassay,CMIA)和酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)对乙型肝炎病毒(Hepatitis B virus,HBV)感染患者血清学标志物诊断准确率的临床应用价值.方法:回顾性选取我院2020年5月至2022年4月就诊的85例HBV感染患者,并采用CMIA法、ELISA法分析HBV感染的准确率、血清学标志物检测结果[乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)、乙肝e抗体(Hepatitis B e antibody,HBeAb)、乙肝e抗原(Hepatitis B e antigen,HBeAg)、乙肝核心抗体(Hepatitis B core antibody,HBcAb)浓度]、HBsAb、HBsAg回收率.结果:CMIA法诊断准确率,检测HBsAg、HBeAb、HBcAb阳性率高于ELISA法(P<0.05);两组平均回收率无统计学差异.结论:与ELISA法相比,CMIA法用于检测HBV感染患者血清学标志物具有较高准确度、回收率.
基金financially supported by the National Natural Science Foundation of China (Grant No. 22275173)the Open Project of State Key Laboratory of Environment-friendly Energy Materials (Grant No. 22kfhg10)。
文摘The poor thermal stability and high sensitivity severely hinder the practical application of hexanitrohexaazaisowurtzitane(CL-20).Herein,a kind of novel core@double-shell CL-20 based energetic composites were fabricated to address the above issues.The coordination complexes which consist of natural polyphenol tannic acid(TA) and Fe~Ⅲ were chosen to construct the inner shell,while the graphene sheets were used to build the outer shell.The resulting CL-20/TA-Fe~Ⅲ/graphene composites exhibited simultaneously improved thermal stability and safety performance with only 1 wt% double-shell content,which should be ascribed to the intense physical encapsulation effect from inner shell combined with the desensitization effect of carbon nano-materials from outer shell.The phase transition(ε to γ) temperature increased from 173.70 ℃ of pure CL-20 to 191.87℃ of CL-20/TA-Fe~Ⅲ/graphene composites.Meanwhile,the characteristic drop height(H_(50)) dramatically increased from 14.7 cm of pure CL-20 to112.8 cm of CL-20/TA-Fe~Ⅲ/graphene composites,indicating much superior safety performance after the construction of the double-shell structure.In general,this work has provided an effective and versatile strategy to conquer the thermal stability and safety issues of CL-20 and contributes to the future application of high energy density energetic materials.
文摘井下斜坡道的定位与建图是实现井下斜坡道无人驾驶的关键技术之一,矿山井下斜坡道区域为典型非结构化环境特征,且道路具有一定倾斜角度,采用传统SLAM算法无法获得精确里程计信息,导致定位与建图精度难以满足无人矿卡行驶需求。针对上述问题,通过研究激光SLAM(Simultaneous Localization And Mapping)算法LeGO-LOAM,笔者提出一种适用于矿山井下斜坡道环境的定位与建图方法。首先,针对井下斜坡道口两侧均为光滑水泥墙壁,特征点稀少问题,设计了基于人工路标的辅助增强定位方法,有效增加点云特征数量,从而优化位姿估计结果,避免建图漂移现象;然后在特征预处理阶段,提出了一种基于激光点云高度差与坡度信息融合的提取地面点高效算法,通过改善地面地点的选取策略,针对倾斜坑洼路面仍能有效识别地面点,解决了井下斜坡道定位与建图倾斜角度大、误差大等问题;其次,基于CVC(Curved-Voxel Clustering)聚类算法设计了一种斜坡道点云曲率体素聚类算法,采用曲率体素和基于哈希的数据结构对点云进行分割,大幅提高在井下稀疏、噪声环境下点云聚类的鲁棒性;最后,运用Scan-To-Map进行点云匹配,同时兼顾点云配准的性能与速度。在中钢集团山东某井下斜坡道的现场实验证明:与原算法相比精度提升13.15%,Z轴误差降低22.3%,地图质量明显提升,能有效解决井下无人驾驶建图及定位的难题。
