自身免疫性疾病是一类可累及多组织器官的全身性疾病,且皮肤受累是其常见的临床表现。Janus酪氨酸激酶(Janus kinase,JAK)-信号转导及转录激活因子(signal transducers and activators of transcription,STAT)通路参与多种自身免疫性疾...自身免疫性疾病是一类可累及多组织器官的全身性疾病,且皮肤受累是其常见的临床表现。Janus酪氨酸激酶(Janus kinase,JAK)-信号转导及转录激活因子(signal transducers and activators of transcription,STAT)通路参与多种自身免疫性疾病的皮损形成[1]。目前,JAK抑制剂已在临床用于治疗多种皮肤疾病,包括特应性皮炎、斑秃、银屑病和白癜风等。展开更多
Hot compression tests of 3Cr2NiMnMo steel were performed at temperatures in the range of 850 to 1 100 ℃ and with strain rates of 10 ^-2 s^- 1 to 1 s ^-1. Both the constitutive equations and the hot deformation activa...Hot compression tests of 3Cr2NiMnMo steel were performed at temperatures in the range of 850 to 1 100 ℃ and with strain rates of 10 ^-2 s^- 1 to 1 s ^-1. Both the constitutive equations and the hot deformation activation energy were derived from the correlativity of flow stress, strain rate and temperature. The mathematical models of the dynamic recrystaIiization of 3Cr2NiMnMo steel, which inelude the dynamic recrystallization kinetics model and the crystalliza- tion grain size model, are based on Avrami＇s law and the results of thermosimulation experiments. By integrating de- rived dynamic recrystallization models with the thermal mechanical coupled finite element method, the microstruc ture evolution in hot compressive deformation was simulated. The distribution of dynamic recrystallization grains and grain sizes were determined through a comparison of the simulation results with the experimental results. The distri- bution of strain and dynamic recrystallization grain is also discussed. The similarity between the experimental results and the simulated results indicates that the derived dynamic recrystallization models can be applied effectively to pre diet and analyze the microstructure evolution in hot deformed 3Cr2NiMnMo steel.展开更多
文摘自身免疫性疾病是一类可累及多组织器官的全身性疾病,且皮肤受累是其常见的临床表现。Janus酪氨酸激酶(Janus kinase,JAK)-信号转导及转录激活因子(signal transducers and activators of transcription,STAT)通路参与多种自身免疫性疾病的皮损形成[1]。目前,JAK抑制剂已在临床用于治疗多种皮肤疾病,包括特应性皮炎、斑秃、银屑病和白癜风等。
基金Sponsored by Innovation Program of Shanghai Municipal Education Commission of China(12ZZ183)Shanghai IndustryUniversity Coorperation Projects of China(12QY20)
文摘Hot compression tests of 3Cr2NiMnMo steel were performed at temperatures in the range of 850 to 1 100 ℃ and with strain rates of 10 ^-2 s^- 1 to 1 s ^-1. Both the constitutive equations and the hot deformation activation energy were derived from the correlativity of flow stress, strain rate and temperature. The mathematical models of the dynamic recrystaIiization of 3Cr2NiMnMo steel, which inelude the dynamic recrystallization kinetics model and the crystalliza- tion grain size model, are based on Avrami＇s law and the results of thermosimulation experiments. By integrating de- rived dynamic recrystallization models with the thermal mechanical coupled finite element method, the microstruc ture evolution in hot compressive deformation was simulated. The distribution of dynamic recrystallization grains and grain sizes were determined through a comparison of the simulation results with the experimental results. The distri- bution of strain and dynamic recrystallization grain is also discussed. The similarity between the experimental results and the simulated results indicates that the derived dynamic recrystallization models can be applied effectively to pre diet and analyze the microstructure evolution in hot deformed 3Cr2NiMnMo steel.
