Continental epithermal ore deposits are commonly associated with sedimentary organic matter,oils or solid bitumen.These organics embedded in mineral deposits can convey valuable information of the ore genesis.However,...Continental epithermal ore deposits are commonly associated with sedimentary organic matter,oils or solid bitumen.These organics embedded in mineral deposits can convey valuable information of the ore genesis.However,the extent to which the formation of ore minerals was recorded by organic compounds remains largely unknown,as also is how metal-rich ores interfere with the molecular proxies in the temperature regime envisaged for hydrothermal activity.The molecular compositional changes of various polycyclic aromatic steranes and polycyclic aromatic hydrocarbons and compounds derived from the Jinding Pb/Zn deposit,SW China provide new data.Aliphatic regular steranes are present as traces.The transformation from polycyclic aromatic steranes to unsubstituted polycyclic aromatic hydrocarbons is observed to show an increased trend with increasing hydrothermal alteration levels;this is consistent with the transformation from unsubstituted polycyclic aromatic hydrocarbons to heterocyclic compounds.Dehydrocyclization(aromatization)of polycyclic biological compounds and hydrodecyclization(dearomatization)of polycyclic aromatic compounds are two important reaction pathways in hydrothermal systems with moderate temperature.This detailed investigation of organicinorganic interactions of two groups of polycyclic compounds with metal-rich ores provides insights into the questions on how and to what extent the formation of Pb/Zn deposits can be recorded by organics.This work will improve our understanding of carbon reduction,oxidation or condensation in the deep Earth and the carbon exchange between the Earth's crust and mantle,and may shed light on the processes for ultra-deep hydrocarbon exploration.展开更多
胆盐水解酶(Bile salt hydrolase,BSH)广泛存在于哺乳动物胃肠道中,是肠道菌群在生长、繁殖过程中产生的一种胞内酶,可以调节宿主的胆汁酸平衡,影响脂质代谢,有控制胆固醇、调节肠道疾病的作用,并且BSH这种调控作用可以实现益生菌部分...胆盐水解酶(Bile salt hydrolase,BSH)广泛存在于哺乳动物胃肠道中,是肠道菌群在生长、繁殖过程中产生的一种胞内酶,可以调节宿主的胆汁酸平衡,影响脂质代谢,有控制胆固醇、调节肠道疾病的作用,并且BSH这种调控作用可以实现益生菌部分益生功能,因此BSH一直是研究热点。BSH结构和底物特异性的详细知识是开发BSH相关产品的坚实基础。本文介绍了BSH的来源及活性检测方法,BSH基因结构、酶学性质及底物识别机制,最后讨论了BSH在畜禽业食品工业及医药等方面的应用,期望为胆盐水解酶的深入研究及其在食品、保健品及医药方面的开发利用提供参考。展开更多
基金financially supported by the National Key Research and Development Program of China(Grant No.2019YFA0708504)National Natural Science Foundation of China(Grant Nos.U20B6001,42141021,42102185)。
文摘Continental epithermal ore deposits are commonly associated with sedimentary organic matter,oils or solid bitumen.These organics embedded in mineral deposits can convey valuable information of the ore genesis.However,the extent to which the formation of ore minerals was recorded by organic compounds remains largely unknown,as also is how metal-rich ores interfere with the molecular proxies in the temperature regime envisaged for hydrothermal activity.The molecular compositional changes of various polycyclic aromatic steranes and polycyclic aromatic hydrocarbons and compounds derived from the Jinding Pb/Zn deposit,SW China provide new data.Aliphatic regular steranes are present as traces.The transformation from polycyclic aromatic steranes to unsubstituted polycyclic aromatic hydrocarbons is observed to show an increased trend with increasing hydrothermal alteration levels;this is consistent with the transformation from unsubstituted polycyclic aromatic hydrocarbons to heterocyclic compounds.Dehydrocyclization(aromatization)of polycyclic biological compounds and hydrodecyclization(dearomatization)of polycyclic aromatic compounds are two important reaction pathways in hydrothermal systems with moderate temperature.This detailed investigation of organicinorganic interactions of two groups of polycyclic compounds with metal-rich ores provides insights into the questions on how and to what extent the formation of Pb/Zn deposits can be recorded by organics.This work will improve our understanding of carbon reduction,oxidation or condensation in the deep Earth and the carbon exchange between the Earth's crust and mantle,and may shed light on the processes for ultra-deep hydrocarbon exploration.
文摘胆盐水解酶(Bile salt hydrolase,BSH)广泛存在于哺乳动物胃肠道中,是肠道菌群在生长、繁殖过程中产生的一种胞内酶,可以调节宿主的胆汁酸平衡,影响脂质代谢,有控制胆固醇、调节肠道疾病的作用,并且BSH这种调控作用可以实现益生菌部分益生功能,因此BSH一直是研究热点。BSH结构和底物特异性的详细知识是开发BSH相关产品的坚实基础。本文介绍了BSH的来源及活性检测方法,BSH基因结构、酶学性质及底物识别机制,最后讨论了BSH在畜禽业食品工业及医药等方面的应用,期望为胆盐水解酶的深入研究及其在食品、保健品及医药方面的开发利用提供参考。
