Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although t...Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although the current diagnosis and treatment equipment and drug research and development keep pace with the times, the current medical technology still can not completely cure the disease, so it is of great significance to explore the pathogenesis and treatment target of AD. The disorder of energy metabolism is one of the characteristic changes in the pathological process of AD. Aerobic glycolysis (AEG) is a special metabolic pathway in the brain, which can rapidly consume glucose to produce energy and substrate for neurons, improve synaptic plasticity, neuroinflammation and oxidative damage, and contribute to the recovery of memory and cognitive function. In recent years, many literatures have reported the mechanism of AEG in AD and the intervention of Tradit Chin Med on this mechanism. The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by Tradit Chin Med, in order to provide reference and ideas for the prevention and treatment of AD with Tradit Chin Med in the future.展开更多
The waveguide invariant,denoted asβ,can be used to describe the slope of the intensity of a broadband acoustic signal.In deep water,the interference patterns of the areas with dominant waterborne modes and only with ...The waveguide invariant,denoted asβ,can be used to describe the slope of the intensity of a broadband acoustic signal.In deep water,the interference patterns of the areas with dominant waterborne modes and only with bottom bounce modes are greatly different.This phenomenon is illustrated by simulation and explained by the distribution ofβ.The theory shows that in the convergence zone,βapproaches infinity,which leads to the larger slope of sound intensity;on the contrary,in the shadow zone,βis close to 1,leading to smaller slopes.展开更多
In a realistic application of matched field processing for source localization,the ability to localize an acoustic source is strongly affected by the uncertainty of the environment.However,accurate environment measure...In a realistic application of matched field processing for source localization,the ability to localize an acoustic source is strongly affected by the uncertainty of the environment.However,accurate environment measurement is a difficult task in large regions of the ocean.We employ a Bayesian approach,referred to here as focalization,to overcome the mismatch by including the environment in the parameter search space.Focalization maximizes the posterior probability density over the unknown source and environmental parameters.The broadband signals recorded by a vertical line array in a Yellow Sea experiment are presented to demonstrate the feasibility of focalization.展开更多
基金Project(52108363) supported by the National Natural Science Foundation of ChinaProjects(2021M700654, 2023T160074) supported by the Postdoctoral Research Foundation of China+2 种基金Project(TUL2022-01) supported by the Key Laboratory of Urban Underground Engineering of Ministry of Education,ChinaProject(XLYC1905015) supported by the Liaoning Revitalization Talents Program,ChinaProject(LJKZZ20220003) supported by the key Project of Liaoning Education Department,China。
文摘选取HC700/980DHD+Z、 HC780/980CPD+Z和HC700/980DPD+Z进行分析,对比了3种材料力学性能和极限冷弯性能的差异;基于5种硬化模型对材料性能曲线进行拟合,选取两类拟合度较高的模型构建了组合硬化模型,并采用R5缺口拉伸试验进行了验证;基于前防撞梁静态三点弯曲测试和仿真对标分析,对组合硬化模型进行验证,并对3种材料的承载性能进行对比分析。结果表明:HC700/980DHD+Z和HC780/980CPD+Z的极限冷弯角分别为109.8°和109.6°,优于HC700/980DPD+Z;前纵梁静态三点弯曲试验测试与仿真分析中关键参数的最大误差在6%左右,表明材料本构模型的精度较高;HC780/980CPD+Z的承载力峰值最大,达到15.1 k N;HC700/980DHD+Z达到承载力峰值的位移最大,达到52 mm;屈强比对静态承载过程的峰值力产生重要影响,而断后伸长率的增加提升了材料的强塑积和塑性应变变形,使得承载力峰值的位移增大。
基金National Natural Science Foundation of China Regional Fund(No.82060844)Guangxi Natural Science Foundation General Project(No.2022GXNSFAA035461)+4 种基金Guangxi Clinical Medical Research Center for Tradit Chin Med Encephalopathy(No.Guike AD20238028)Academic Team Construction Project of the First Affiliated Hospital of Guangxi Univ Tradit Chin Med[Hospital Letter(2018)No.146]The 2020 Guangxi Higher Education High level Innovation Team and Outstanding Scholar Program[Guijiao Talent(2020)No.6]Guangxi Univ Tradit Chin Med"Qihuang Project"High level Talent Team Cultivation Project(No.2018003)Guangxi Key Discipline Construction Project of Tradit Chin Med(No.GZXK-Z-20-13)Alzheimer’s disease(AD)is an irreversible neurodegenerative disease.At present,the number of AD cases has exceeded 30 million and continues to rise in the world,especially in developing countries including China.Due to the superposition of factors such as an aging population,social pressure and improper lifestyle,it is speculated that the number of AD cases will double in the next 30 years[1].Although a large amount of money has been invested in the drug development and diagnosis and treatment of AD,the current medical methods can only delay the disease of AD but can not cure it completely.It is undeniable that AD is a recognized health problem and health problem in the current society.Therefore,it is particularly important to further study the molecular mechanism of AD in order to identify the pathogenic factors and therapeutic targets,and to explore effective treatment.Modern medicine believes that its pathological mechanism is complex and interact with each other,includingβ-amyloid(Aβ)toxic damage,abnormal modification of Tau protein,oxidative stress,neuroinflammation,mitochondrial dysfunction and so on[2].In fact,in the process of inevitable aging,the metabolic network is affected by related signal pathways,proteins and genes,which leads to the gradual down-regulation of aerobic glycolysis(AEG),which can directly or indirectly participate in the pathogenesis of the above-mentioned AD and affect its pathological changes.Therefore,taking AEG as the research target can provide a new idea for the prevention and treatment of AD.The name of AD disease is not seen in Tradit Chin Med,and it is Alzheimer's disease(AD)is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis,so that the disease has a high prevalence and mortality in the world.Although the current diagnosis and treatment equipment and drug research and development keep pace with the times,the current medical technology still can not completely cure the disease,so it is of great significance to explore the pathogenesis and treatment target of AD.The disorder of energy metabolism is one of the characteristic changes in the pathological process of AD.Aerobic glycolysis(AEG)is a special metabolic pathway in the brain,which can rapidly consume glucose to produce energy and substrate for neurons,improve synaptic plasticity,neuroinflammation and oxidative damage,and contribute to the recovery of memory and cognitive function.In recent years,many literatures have reported the mechanism of AEG in AD and the intervention of Tradit Chin Med on this mechanism.The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by Tradit Chin Med,in order to provide reference and ideas for the prevention and treatment of AD with Tradit Chin Med in the future。
文摘Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although the current diagnosis and treatment equipment and drug research and development keep pace with the times, the current medical technology still can not completely cure the disease, so it is of great significance to explore the pathogenesis and treatment target of AD. The disorder of energy metabolism is one of the characteristic changes in the pathological process of AD. Aerobic glycolysis (AEG) is a special metabolic pathway in the brain, which can rapidly consume glucose to produce energy and substrate for neurons, improve synaptic plasticity, neuroinflammation and oxidative damage, and contribute to the recovery of memory and cognitive function. In recent years, many literatures have reported the mechanism of AEG in AD and the intervention of Tradit Chin Med on this mechanism. The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by Tradit Chin Med, in order to provide reference and ideas for the prevention and treatment of AD with Tradit Chin Med in the future.
基金Supported by the National Natural Science Foundation of China under Grant Nos 10974218 and 10734100and the Knowledge Innovation Program of Chinese Academy of Sciences(KZCX1-YW-12-2).
文摘The waveguide invariant,denoted asβ,can be used to describe the slope of the intensity of a broadband acoustic signal.In deep water,the interference patterns of the areas with dominant waterborne modes and only with bottom bounce modes are greatly different.This phenomenon is illustrated by simulation and explained by the distribution ofβ.The theory shows that in the convergence zone,βapproaches infinity,which leads to the larger slope of sound intensity;on the contrary,in the shadow zone,βis close to 1,leading to smaller slopes.
基金Supported by the National Natural Science Foundation of China under Grant Nos 10974218 and 10734100the Knowledge Innovation Program of Chinese Academy of Sciences(KZCX1-YW-12-2)。
文摘In a realistic application of matched field processing for source localization,the ability to localize an acoustic source is strongly affected by the uncertainty of the environment.However,accurate environment measurement is a difficult task in large regions of the ocean.We employ a Bayesian approach,referred to here as focalization,to overcome the mismatch by including the environment in the parameter search space.Focalization maximizes the posterior probability density over the unknown source and environmental parameters.The broadband signals recorded by a vertical line array in a Yellow Sea experiment are presented to demonstrate the feasibility of focalization.
