In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8（vanen）3（NO3）2（CH3OH）2（H2O）·3NO3· 5.5H2O]（abbreviated as Bivanen） was synthesized with Salen-like ligand Hzvanen[Hzvanen=N,N＇-ethylene...In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8（vanen）3（NO3）2（CH3OH）2（H2O）·3NO3· 5.5H2O]（abbreviated as Bivanen） was synthesized with Salen-like ligand Hzvanen[Hzvanen=N,N＇-ethylene bis（3-methoxysalicylideneimine）] and bismuth（III） nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaecharomyees pombe（S, pombe） were studied using biological mierocalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 ℃. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant（k）, inhibition ratio（I） and half inhibition concentration（IC50） were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.展开更多
In this work, the binding interaction between a new bismuth（HI） Schiff base complex{ [Bi（valen）]C1.2H2O} [H2valen=N,N′bis（2-hydroxy-3-methoxyphenylmethylidene）-2,6-pyridinediamine, C2 IH19N3O4]and bovine serum ...In this work, the binding interaction between a new bismuth（HI） Schiff base complex{ [Bi（valen）]C1.2H2O} [H2valen=N,N′bis（2-hydroxy-3-methoxyphenylmethylidene）-2,6-pyridinediamine, C2 IH19N3O4]and bovine serum albumin（BSA） was studied via fluorescence quenching method. The static quenching constant KLBand some thermodynamic parameters（e.g.,△G^θ, △H^θ and △S^θ） of the interaction were estimated. In particular, thebinding site between the complex and BSA was explored by molecular docking. On the basis of the mechanism ofFOrster energy transfer, the binding distance between the bismuth（Ⅲ） Schiff base complex and BSA（Trp.213） as wellas the transfer efficiency was obtained. Furthermore, the effect of the bismuth（Ⅲ） Schiff base complex on the con-formation of BSA was investigated using synchronous fluorescence spectroscopy.展开更多
基金Supported by the National Natural Science Foundation of China（Nos.21273190, 20973145） and the Science and Technology Plan Projects of Hunan Province, China（Nos.2014F J3011, 2013F J3033, 2014TT2026）.
文摘In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8（vanen）3（NO3）2（CH3OH）2（H2O）·3NO3· 5.5H2O]（abbreviated as Bivanen） was synthesized with Salen-like ligand Hzvanen[Hzvanen=N,N＇-ethylene bis（3-methoxysalicylideneimine）] and bismuth（III） nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaecharomyees pombe（S, pombe） were studied using biological mierocalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 ℃. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant（k）, inhibition ratio（I） and half inhibition concentration（IC50） were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.
文摘In this work, the binding interaction between a new bismuth（HI） Schiff base complex{ [Bi（valen）]C1.2H2O} [H2valen=N,N′bis（2-hydroxy-3-methoxyphenylmethylidene）-2,6-pyridinediamine, C2 IH19N3O4]and bovine serum albumin（BSA） was studied via fluorescence quenching method. The static quenching constant KLBand some thermodynamic parameters（e.g.,△G^θ, △H^θ and △S^θ） of the interaction were estimated. In particular, thebinding site between the complex and BSA was explored by molecular docking. On the basis of the mechanism ofFOrster energy transfer, the binding distance between the bismuth（Ⅲ） Schiff base complex and BSA（Trp.213） as wellas the transfer efficiency was obtained. Furthermore, the effect of the bismuth（Ⅲ） Schiff base complex on the con-formation of BSA was investigated using synchronous fluorescence spectroscopy.
