目的:探究双层软组织缝合封闭技术在单纯应用抗骨吸收药物引起的发生在下颌骨的中早期药物相关性颌骨骨坏死(medication-related osteonecrosis of the jaw,MRONJ)患者手术治疗中的临床应用效果。方法:选择2021年10月至2022年9月于北京...目的:探究双层软组织缝合封闭技术在单纯应用抗骨吸收药物引起的发生在下颌骨的中早期药物相关性颌骨骨坏死(medication-related osteonecrosis of the jaw,MRONJ)患者手术治疗中的临床应用效果。方法:选择2021年10月至2022年9月于北京大学口腔医院四病区经手术治疗的中早期下颌骨MRONJ患者的病历资料进行回顾性分析,收集患者术前基线临床资料,包括原发疾病、伴发疾病、用药方案(药物种类、用药时长)、MRONJ分期、临床症状、影像学表现等,所有患者在手术中行下颌骨边缘切除术去除坏死骨,运用双层软组织缝合封闭技术关闭伤口,术后定期复查随访,评价双层软组织缝合封闭技术的治疗效果及并发症,并对患者进行疼痛评分和功能状态评价。结果:研究共纳入13例患者(女12例,男1例),年龄(66.69±13.14)岁。原发疾病包括骨质疏松7例,肺癌2例,乳腺癌3例,前列腺癌1例;2例伴发糖尿病,2例伴发心血管疾病,1例伴发干燥综合征。9例患者静脉注射唑来膦酸,平均用药时间(37.7±20.0)个月,7例患者同时服用了来曲唑片等其他药物;3例患者应用地舒单抗注射液,平均用药时间(10.3±11.9)个月;5例患者服用阿仑膦酸钠片,平均用药时间(55.20±27.20)个月,2例患者不同程度地服用醋酸泼尼松片或阿卡波糖片。MRONJ 1期4例,2期9例。13例患者均采用双层软组织缝合封闭技术关闭伤口,术后平均随访11.9个月(9~17个月),13例患者皆治愈,无溢脓等并发症发生。患者术前Karnofsky功能状态评分量表(Karnofsky performance status,KPS)评分为(68.46±14.05)分,术后评分为(82.31±15.36)分,差异有统计学意义(P<0.05)。患者术前疼痛评估视觉模拟评分量表(visual analogue scale,VAS)评分为(5.77±0.73)分,术后评分为(0.38±0.51)分,差异有统计学意义(P<0.001)。结论:双层软组织缝合封闭技术在中早期单纯使用抗骨吸收类药物的下颌骨MRONJ患者中可以取得良好的临床治疗效果,可为用药情况更加复杂的MRONJ患者提供临床治疗思路。展开更多
In 2006,the National Meteorological Information Center （NMIC） of the China Meteorological Administration （CMA） developed its real-time quality control （QC） system of rawinsonde observations coming from the Globa...In 2006,the National Meteorological Information Center （NMIC） of the China Meteorological Administration （CMA） developed its real-time quality control （QC） system of rawinsonde observations coming from the Global Telecommunications System （GTS） and established the Global Upper-air Report Dataset,which,with the NMIC B01 format,is generally referred to as the B01 dataset and updated on a daily basis.However,when the B01 dataset is applied in climate analysis,some wind errors as well as some accurate values with incorrect error marks are found.To improve the quality and usefulness of Chinese rawinsonde wind observations,a new QC method （NewQC） is proposed in this paper.Different from the QC approach used for B01 datasets,the NewQC includes two vertical-wind-shear checks to analyze the vertical consistency of winds,in which the constant height level winds are used as reference data for the QC of mandatory pressure level winds.Different threshold values are adopted in the wind shear checks for different stations and different vertical levels.Several typical examples of QC of different error types by the new algorithm are shown and its performance with respect to 1980-2008 observational data is statistically evaluated.Compared with the radiosonde QC algorithms used in both the Meteorological Assimilation Data Ingest System （MADIS,http：//madis.noaa.gov/madis_raob_qc.html） of the National Oceanic and Atmospheric Administration （NOAA） and the B01 dataset,the NewQC shows higher accuracy and better reliability,particularly when used to judge successive observation errors.展开更多
文摘目的:探究双层软组织缝合封闭技术在单纯应用抗骨吸收药物引起的发生在下颌骨的中早期药物相关性颌骨骨坏死(medication-related osteonecrosis of the jaw,MRONJ)患者手术治疗中的临床应用效果。方法:选择2021年10月至2022年9月于北京大学口腔医院四病区经手术治疗的中早期下颌骨MRONJ患者的病历资料进行回顾性分析,收集患者术前基线临床资料,包括原发疾病、伴发疾病、用药方案(药物种类、用药时长)、MRONJ分期、临床症状、影像学表现等,所有患者在手术中行下颌骨边缘切除术去除坏死骨,运用双层软组织缝合封闭技术关闭伤口,术后定期复查随访,评价双层软组织缝合封闭技术的治疗效果及并发症,并对患者进行疼痛评分和功能状态评价。结果:研究共纳入13例患者(女12例,男1例),年龄(66.69±13.14)岁。原发疾病包括骨质疏松7例,肺癌2例,乳腺癌3例,前列腺癌1例;2例伴发糖尿病,2例伴发心血管疾病,1例伴发干燥综合征。9例患者静脉注射唑来膦酸,平均用药时间(37.7±20.0)个月,7例患者同时服用了来曲唑片等其他药物;3例患者应用地舒单抗注射液,平均用药时间(10.3±11.9)个月;5例患者服用阿仑膦酸钠片,平均用药时间(55.20±27.20)个月,2例患者不同程度地服用醋酸泼尼松片或阿卡波糖片。MRONJ 1期4例,2期9例。13例患者均采用双层软组织缝合封闭技术关闭伤口,术后平均随访11.9个月(9~17个月),13例患者皆治愈,无溢脓等并发症发生。患者术前Karnofsky功能状态评分量表(Karnofsky performance status,KPS)评分为(68.46±14.05)分,术后评分为(82.31±15.36)分,差异有统计学意义(P<0.05)。患者术前疼痛评估视觉模拟评分量表(visual analogue scale,VAS)评分为(5.77±0.73)分,术后评分为(0.38±0.51)分,差异有统计学意义(P<0.001)。结论:双层软组织缝合封闭技术在中早期单纯使用抗骨吸收类药物的下颌骨MRONJ患者中可以取得良好的临床治疗效果,可为用药情况更加复杂的MRONJ患者提供临床治疗思路。
基金supported by the 973 project "Assessment, Assimilation, Recompilation and Applications of Fundamental and Thematic Climate Data Records" (Grant No.2010CB951600)the National Science and Technology Supporting Program of the 12th Five-Year Plan Period (Grant No.2012BAC22B00)the"Monitoring and Detection of Aerial Climate Change in China" project of the China Meteorological Administration (Grant No.GYHY200906014)
文摘In 2006,the National Meteorological Information Center （NMIC） of the China Meteorological Administration （CMA） developed its real-time quality control （QC） system of rawinsonde observations coming from the Global Telecommunications System （GTS） and established the Global Upper-air Report Dataset,which,with the NMIC B01 format,is generally referred to as the B01 dataset and updated on a daily basis.However,when the B01 dataset is applied in climate analysis,some wind errors as well as some accurate values with incorrect error marks are found.To improve the quality and usefulness of Chinese rawinsonde wind observations,a new QC method （NewQC） is proposed in this paper.Different from the QC approach used for B01 datasets,the NewQC includes two vertical-wind-shear checks to analyze the vertical consistency of winds,in which the constant height level winds are used as reference data for the QC of mandatory pressure level winds.Different threshold values are adopted in the wind shear checks for different stations and different vertical levels.Several typical examples of QC of different error types by the new algorithm are shown and its performance with respect to 1980-2008 observational data is statistically evaluated.Compared with the radiosonde QC algorithms used in both the Meteorological Assimilation Data Ingest System （MADIS,http：//madis.noaa.gov/madis_raob_qc.html） of the National Oceanic and Atmospheric Administration （NOAA） and the B01 dataset,the NewQC shows higher accuracy and better reliability,particularly when used to judge successive observation errors.
