目的:研究血清炎症因子粒细胞集落刺激因子(G-CSF)、单核细胞趋化蛋白-1(MCP-1)、干扰素诱导蛋白-10(IP-10)在支气管肺发育不良(BPD)早产儿中的表达及其临床意义。方法:选取自2018年1月至2019年9月本院儿科收治的126例早产儿作为研究对...目的:研究血清炎症因子粒细胞集落刺激因子(G-CSF)、单核细胞趋化蛋白-1(MCP-1)、干扰素诱导蛋白-10(IP-10)在支气管肺发育不良(BPD)早产儿中的表达及其临床意义。方法:选取自2018年1月至2019年9月本院儿科收治的126例早产儿作为研究对象(胎龄<32周和/或出生体重≤1500g),根据病情分为非BPD组48例,BPD组78例,其中轻度BPD组30例,中度BPD组31例及重度BPD组17例。采用酶联免疫吸附实验(ELISA)检测各组患儿生后不同时间点血清G-CSF、MCP-1、IP-10水平的差异。受试者工作曲线(ROC)分析血清G-CSF、MCP-1、IP-10对BPD的诊断价值。结果:与非BPD组比较,BPD组早产儿胎龄和出生体重均较小,5 min Apgar评分明显较低,机械通气时间和总吸氧时间较长,新生儿肺炎和新生儿窒息发生率较高(均P<0.05);BPD组各时间点血清G-CSF、MCP-1及IP-10水平明显升高(均P<0.05)。重度BPD组早产儿在第14天和第28天时血清G-CSF,MCP-1及IP-10水平明显高于轻度、中度BPD组患儿(P<0.05)。第1天血清G-CSF、MCP-1、IP-10的ROC曲线下面积(AUC)分别为0.763、0.751及0.766,第14天分别为0.913、0.925及0.867。结论:BPD患儿血清G-CSF、MCP-1、IP-10水平明显升高,并且升高的程度与BPD疾病严重程度有关,检测早产儿血清G-CSF、MCP-1、IP-10水平有助于BPD的早期诊断。展开更多
针对数字助听器中现存声源定位算法精确度低和算法复杂度高的问题,提出一种新的双耳声源定位算法.首先,采集到的双耳声源信号通过Gammatone滤波器分解为若干个子带信号,根据能量的大小对数据进行压缩.然后,利用头相关传递函数(head-rela...针对数字助听器中现存声源定位算法精确度低和算法复杂度高的问题,提出一种新的双耳声源定位算法.首先,采集到的双耳声源信号通过Gammatone滤波器分解为若干个子带信号,根据能量的大小对数据进行压缩.然后,利用头相关传递函数(head-related transfer function,HRTF)中包含的双耳线索,即双耳时间差、双耳声级差及耳间相关性,提取声源位置的特征.最后,声源的位置信息由高斯混合模型(Gaussian mixture model,GMM)分类器识别.实验结果表明,建议的算法具有高精确度、低复杂度及强鲁棒性.展开更多
Marine biodiversity in almost all oceans is being threatened at the genetic, species, and ecosystem levels. The marine ecosystem is being degraded and the extinction rate of marine organisms has accelerated. In this p...Marine biodiversity in almost all oceans is being threatened at the genetic, species, and ecosystem levels. The marine ecosystem is being degraded and the extinction rate of marine organisms has accelerated. In this paper, the potential causes of fishery resource exhaustion in the East China Sea are analyzed, including the change in the stoichiometric composition of seawater with regard to the concentrations of N and P, toxic effects of marine pollution, marine habitat destruction, increased seawater temperatures caused by climate warming, ocean acidification, pressure from overfishing, and the spread of marine pathogenic bacteria. It is believed that the factors mentioned above have significant impact on the exhaustion of fishery resources in the East China Sea. However, considering the cumulative, synergistic, and superimposed effects as well as the amplification effects resulting from their interactions, the actual risk of ecological extinction of marine organisms might be even more severe than that previously estimated. Hence, ecosystem management and research focused on a single risk factor or influencing factor is not enough to prevent marine ecosystem degradation and fishery resource exhaustion. A comprehensive, systematic, effective, and ecosystem-based management policy is imperative for healthy and sustainable fishery development in the East China Sea.展开更多
文摘目的:研究血清炎症因子粒细胞集落刺激因子(G-CSF)、单核细胞趋化蛋白-1(MCP-1)、干扰素诱导蛋白-10(IP-10)在支气管肺发育不良(BPD)早产儿中的表达及其临床意义。方法:选取自2018年1月至2019年9月本院儿科收治的126例早产儿作为研究对象(胎龄<32周和/或出生体重≤1500g),根据病情分为非BPD组48例,BPD组78例,其中轻度BPD组30例,中度BPD组31例及重度BPD组17例。采用酶联免疫吸附实验(ELISA)检测各组患儿生后不同时间点血清G-CSF、MCP-1、IP-10水平的差异。受试者工作曲线(ROC)分析血清G-CSF、MCP-1、IP-10对BPD的诊断价值。结果:与非BPD组比较,BPD组早产儿胎龄和出生体重均较小,5 min Apgar评分明显较低,机械通气时间和总吸氧时间较长,新生儿肺炎和新生儿窒息发生率较高(均P<0.05);BPD组各时间点血清G-CSF、MCP-1及IP-10水平明显升高(均P<0.05)。重度BPD组早产儿在第14天和第28天时血清G-CSF,MCP-1及IP-10水平明显高于轻度、中度BPD组患儿(P<0.05)。第1天血清G-CSF、MCP-1、IP-10的ROC曲线下面积(AUC)分别为0.763、0.751及0.766,第14天分别为0.913、0.925及0.867。结论:BPD患儿血清G-CSF、MCP-1、IP-10水平明显升高,并且升高的程度与BPD疾病严重程度有关,检测早产儿血清G-CSF、MCP-1、IP-10水平有助于BPD的早期诊断。
文摘针对数字助听器中现存声源定位算法精确度低和算法复杂度高的问题,提出一种新的双耳声源定位算法.首先,采集到的双耳声源信号通过Gammatone滤波器分解为若干个子带信号,根据能量的大小对数据进行压缩.然后,利用头相关传递函数(head-related transfer function,HRTF)中包含的双耳线索,即双耳时间差、双耳声级差及耳间相关性,提取声源位置的特征.最后,声源的位置信息由高斯混合模型(Gaussian mixture model,GMM)分类器识别.实验结果表明,建议的算法具有高精确度、低复杂度及强鲁棒性.
基金supported by the Public Science and Technology Research Funds Projects for Ocean(Grant Nos.201505003201505025)
文摘Marine biodiversity in almost all oceans is being threatened at the genetic, species, and ecosystem levels. The marine ecosystem is being degraded and the extinction rate of marine organisms has accelerated. In this paper, the potential causes of fishery resource exhaustion in the East China Sea are analyzed, including the change in the stoichiometric composition of seawater with regard to the concentrations of N and P, toxic effects of marine pollution, marine habitat destruction, increased seawater temperatures caused by climate warming, ocean acidification, pressure from overfishing, and the spread of marine pathogenic bacteria. It is believed that the factors mentioned above have significant impact on the exhaustion of fishery resources in the East China Sea. However, considering the cumulative, synergistic, and superimposed effects as well as the amplification effects resulting from their interactions, the actual risk of ecological extinction of marine organisms might be even more severe than that previously estimated. Hence, ecosystem management and research focused on a single risk factor or influencing factor is not enough to prevent marine ecosystem degradation and fishery resource exhaustion. A comprehensive, systematic, effective, and ecosystem-based management policy is imperative for healthy and sustainable fishery development in the East China Sea.
