本文报道1例成人同时患有特纳综合征、1型糖尿病、桥本氏甲状腺炎及地中海贫血。患者,女,幼年因身材矮小及青春期无月经来潮行染色体检查,诊断为特纳综合征。应用生长激素治疗及性激素治疗,维持第二性征及提升身高。患者智力未受影响,...本文报道1例成人同时患有特纳综合征、1型糖尿病、桥本氏甲状腺炎及地中海贫血。患者,女,幼年因身材矮小及青春期无月经来潮行染色体检查,诊断为特纳综合征。应用生长激素治疗及性激素治疗,维持第二性征及提升身高。患者智力未受影响,青少年期间未监测血常规及糖代谢。8年前出现口干、多饮、多尿,伴有体重下降,为典型"三多一少"症状,行2 4 h血糖监测,C肽释放功能基本为0,1型糖尿病诊断明确,开始胰岛素泵治疗,因血糖控制不佳,糖化血红蛋白8.2%。2017年7月24日以"1型糖尿病"收入院治疗,在住院检查过程中发现患者甲状腺功能异常,考虑桥本氏甲状腺炎,查血常规Hb正常,但红细胞平均体积(erythrocyte mean corpuscular volume,MC V),红细胞平均血红蛋白量(er y throc y te mean cor puscular hemoglobin,MCH)及红细胞平均血红蛋白浓度(erythrocyte mean corpuscular hemoglobin concentrat,MCHC)低于正常,贫血六项铁及铁蛋白正常,这种小细胞低色素贫血前期改变引起了临床医师的注意,经基因测定(β珠蛋白基因CDs71-72+A突变)证实为β地中海贫血。在该患者身上,特纳综合征及1型糖尿病临床表现比较突出,容易确诊及治疗,但其症状可能掩盖会一些特殊疾病,比如地中海贫血基因携带者。地中海贫血作为一种终身疾病,亦可引起性腺功能减退,继发自身免疫性甲状腺疾病。展开更多
In the diagnosis of rotor crack based on wavelet analysis, it is a painful task to find out an adaptive mother wavelet as many of them can be chosen and the analytic results of different mother wavelets are yet not th...In the diagnosis of rotor crack based on wavelet analysis, it is a painful task to find out an adaptive mother wavelet as many of them can be chosen and the analytic results of different mother wavelets are yet not the same. For this limitation of wavelet analysis, a novel diagnostic approach of rotor crack based on multi-scale singular-spectrum analysis （MS-SSA） is proposed. Firstly, a Jeffcott model of a cracked rotor is developed and the forth-order Runge-Kutta method is used to solve the motion equations of this rotor to obtain its time response （signals）. Secondly, a comparatively simple approach of MS-SSA is presented and the empirical orthogonal functions of different orders in various scales are regarded as analyzing functions. At last, the signals of the cracked rotor and an uncracked rotor are analyzed using the proposed approach of MS-SSA, and the simulative results are compared. The results show that, the data-adaptive analyzing functions can capture many features of signals and the rotor crack can be identified and diagnosed effectively by comparing the analytic results of signals of the cracked rotor with those of the uncracked rotor using the analyzing functions of different orders.展开更多
文摘本文报道1例成人同时患有特纳综合征、1型糖尿病、桥本氏甲状腺炎及地中海贫血。患者,女,幼年因身材矮小及青春期无月经来潮行染色体检查,诊断为特纳综合征。应用生长激素治疗及性激素治疗,维持第二性征及提升身高。患者智力未受影响,青少年期间未监测血常规及糖代谢。8年前出现口干、多饮、多尿,伴有体重下降,为典型"三多一少"症状,行2 4 h血糖监测,C肽释放功能基本为0,1型糖尿病诊断明确,开始胰岛素泵治疗,因血糖控制不佳,糖化血红蛋白8.2%。2017年7月24日以"1型糖尿病"收入院治疗,在住院检查过程中发现患者甲状腺功能异常,考虑桥本氏甲状腺炎,查血常规Hb正常,但红细胞平均体积(erythrocyte mean corpuscular volume,MC V),红细胞平均血红蛋白量(er y throc y te mean cor puscular hemoglobin,MCH)及红细胞平均血红蛋白浓度(erythrocyte mean corpuscular hemoglobin concentrat,MCHC)低于正常,贫血六项铁及铁蛋白正常,这种小细胞低色素贫血前期改变引起了临床医师的注意,经基因测定(β珠蛋白基因CDs71-72+A突变)证实为β地中海贫血。在该患者身上,特纳综合征及1型糖尿病临床表现比较突出,容易确诊及治疗,但其症状可能掩盖会一些特殊疾病,比如地中海贫血基因携带者。地中海贫血作为一种终身疾病,亦可引起性腺功能减退,继发自身免疫性甲状腺疾病。
基金This project is supported by National Fundamental Research and Development Project Foundation of China(No.G1998020321).
文摘In the diagnosis of rotor crack based on wavelet analysis, it is a painful task to find out an adaptive mother wavelet as many of them can be chosen and the analytic results of different mother wavelets are yet not the same. For this limitation of wavelet analysis, a novel diagnostic approach of rotor crack based on multi-scale singular-spectrum analysis （MS-SSA） is proposed. Firstly, a Jeffcott model of a cracked rotor is developed and the forth-order Runge-Kutta method is used to solve the motion equations of this rotor to obtain its time response （signals）. Secondly, a comparatively simple approach of MS-SSA is presented and the empirical orthogonal functions of different orders in various scales are regarded as analyzing functions. At last, the signals of the cracked rotor and an uncracked rotor are analyzed using the proposed approach of MS-SSA, and the simulative results are compared. The results show that, the data-adaptive analyzing functions can capture many features of signals and the rotor crack can be identified and diagnosed effectively by comparing the analytic results of signals of the cracked rotor with those of the uncracked rotor using the analyzing functions of different orders.
