AIM To investigate the effects of Astragalus Membranaceus (AM) on intestinal oxygen consumption both in vivo and in vitro. METHODS The oxygen consumption of the intestine was measured using (A V) O 2 difference a...AIM To investigate the effects of Astragalus Membranaceus (AM) on intestinal oxygen consumption both in vivo and in vitro. METHODS The oxygen consumption of the intestine was measured using (A V) O 2 difference analyzer after placement of different concentrations of AM into the intestinal lumen of 10 anesthetized healthy mongrel dogs. The effects of AM on the oxygen consumption of the intestinal mucosa in vitro were observed using constant volume manometers. RESULTS Placement of different concentrations of AM into the intestinal lumen of mongrel dogs increased the oxygen consumption of the intestine in vivo. The values were significantly different from those of normal saline ( P <0 05 or P <0 01). The oxygen consumption of 30% and 50% concentrations of AM was significantly increased as compared with that of 10% concentration ( P <0 05). There was no significant difference between 30% and 50% concentrations ( P >0 05). The effects of AM on oxygen consumption of intestinal mucosa in vitro were similar to those in vivo. Astragalus Membranaceus at 5% and 1% concentrations could remarkably increase the intestinal oxygen consumption compared with Kreb Ringers phosphate buffer (KRPB) ( P <0 05 or P <0 01). There was no significant difference between 10% concentration and KRPB ( P >0 05). CONCLUSION Astragalus Membranaceus was capable of improving the function of intestinal oxidative metabolism.展开更多
文摘AIM To investigate the effects of Astragalus Membranaceus (AM) on intestinal oxygen consumption both in vivo and in vitro. METHODS The oxygen consumption of the intestine was measured using (A V) O 2 difference analyzer after placement of different concentrations of AM into the intestinal lumen of 10 anesthetized healthy mongrel dogs. The effects of AM on the oxygen consumption of the intestinal mucosa in vitro were observed using constant volume manometers. RESULTS Placement of different concentrations of AM into the intestinal lumen of mongrel dogs increased the oxygen consumption of the intestine in vivo. The values were significantly different from those of normal saline ( P <0 05 or P <0 01). The oxygen consumption of 30% and 50% concentrations of AM was significantly increased as compared with that of 10% concentration ( P <0 05). There was no significant difference between 30% and 50% concentrations ( P >0 05). The effects of AM on oxygen consumption of intestinal mucosa in vitro were similar to those in vivo. Astragalus Membranaceus at 5% and 1% concentrations could remarkably increase the intestinal oxygen consumption compared with Kreb Ringers phosphate buffer (KRPB) ( P <0 05 or P <0 01). There was no significant difference between 10% concentration and KRPB ( P >0 05). CONCLUSION Astragalus Membranaceus was capable of improving the function of intestinal oxidative metabolism.
