基于InSAR和指数分析的地面沉降风险评估与预测——以城市密集高层建筑区为例

传统的沉降风险评价依赖于实地测量监测技术,即使是一系列的观测点数据也难以直观地表现一定区域内地面沉降的空间分布,而有着大范围、高密度、时效性优势的基于合成孔径雷达差分干涉技术(In SAR)的地面沉降监测手段可以更加方便地提取范围内地表形变速率或形变量。通过D-In SAR和PS-In SAR技术分析sentinel-1A数据分别得到地面累积沉降量和年沉降速率信息,运用模糊层次分析法建立易发性指标,结合Python代码设计的ROC曲线利用其ACU值进行检验易发性模型的有效性;通过危险性指数法利用不同程度的降水情况获取失稳概率,得到不同降雨工况下的危险性指标,为定量的沉降易发性评估提供了依据。

改进EMD方法在滑坡变形监测中的应用

为了提高滑坡变形监测数据预测的有效性与准确性,针对端点效应对EMD分解精度的影响,提出一种抑制端点效应的改进EMD方法。该方法基于函数延拓原理,通过构造极值点,避免出现端点效应,最后使用仿真数据与实测滑坡沉降数据对改进EMD方法的性能进行检验。结果表明,改进EMD方法的分解精度相对传统EMD方法更高,改进EMD方法结合BP神经网络模型的预测精度较传统EMD方法的预测精度更高,在实际工程中有着较高的应用价值。

DEM构建及地形特征线提取研究

格网DEM是数字地面模型的重要数据表现形式,基于格网DEM提取的山脊线、山谷线是地形骨架结构的表达与数字地形分析的重要方面。通过比较距离倒数乘方法、自然邻域法、克里金法、薄板样条函数法、趋势面分析法5种空间内插方法在本溪关门山地区的适用性,选出最优法用于格网DEM的构建。基于格网DEM,对比运用水文分析法和曲率判别法两种方法提取山脊线、山谷线的结果,并研究两种提取算法的融合效果。以GeoScene Pro建模和脚本的形式分别实现了DEM构建、等高线曲率计算、山脊线与山谷线提取;制作了本溪关门山地区数字高程模型图、等值线专题图、山脊线与山谷线专题图等。提出了坡度、平面曲率与等高线曲率的转换方法;对水文分析法和曲率判别法做出了改进,并提出了基于水文分析法和曲率判别法的融合算法,进一步提高了山脊线、山谷线提取的准确率。融合算法兼具二者之长,提取结果较为全面,整体性较好。

Electroencephalogram Features of Anxiety Relieving During Music Listening

With the fast-accelerating pace of life,most of the population is troubled by anxious feelings,or they even developed anxiety disorders,which affect their life qualities viciously.The current treatment is not without drawbacks,such as exhibiting slow or acute effects only.Music therapy has shown promising outcomes in significantly reducing tension and anxiety in many studies.To explore the underlying mechanism,we recruited 12 undergraduate student volunteers from Shanghai Jiao Tong University with habits of music listening.We explored the changes in the electroencephalogram(EEG)power spectrum both during and after listening to self-select favorite music,and the relation between EEG signals and anxiety-relieving during music listening.The results showed that the power of the band in the right parietal area was significantly higher in those who were self-report able to relax during music listening compared with those who could not get relaxed.We observed power increased in the right parietal area of self-reports,not able to relax while music playing.Also,a significant difference inband power in the left frontal area and band in the right frontal area before and after music listening was observed between high anxiety group and low anxiety group.These results imply that band activity in the left frontal area is associated with the anxiety-relieving capability of anxiety,which provides evidence for further elucidating the mechanism underlying anxiety-relieving during music listening.

CRISPR/Cas9-mediated mutation of asparagine-linked glycosylation 13 transcript variant 1 causes epilepsy in mice

Objective:The asparagine-linked glycosylation 13 homolog(Alg13)has been identified as causative for congenital disorders of glycosylation type I with epilepsy.The aim of this study was to determine whether mice carrying a mutated version of Alg13 could be used as a model for epileptic encephalopathies or congenital disorders of glycosylation type I.Methods:A model of epileptic encephalopathy was established in C57BL/6 mice by introducing mutations in Alg13 via the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR/Cas9)system.All surgical procedures were approved by the Institutional Animal Care and Use Committee of Shanghai Jiao Tong University(A2016084)on October 8,2016.Results:Mice with 3 different mutations,Alg13^(-54nt),Alg13^(-5nt)and Alg13^(-4nt),all of which are located in Alg13 transcript variant 1,were created.The Alg13^(-5nt)mice exhibited spontaneous seizures similar to patients with Alg13 mutations,suggesting that they could be used as a model for epilepsy.Western blot analysis demonstrated that Alg13^(-5nt)mice had lower levels of Alg13 expression than wild-type mice.Video observations showed that two of the 17 Alg13^(-5nt)mice had stage 5 seizures involving jumping and falling,while 12 had stage 3 seizures with head nodding.Conclusion:The Alg13 mouse model provides an outstanding tool for studying epileptic encephalopathies and investigating different aspects of defects in glycosylation or other post-translational modification that cannot be assessed in patients or cell culture systems.

NMDA诱导成骨细胞内钙离子浓度升高

目的研究N-甲基-D-天冬氨酸(NMDA)对原代培养的大鼠颅盖骨成骨细胞[Ca^2+]i水平的影响。方法利用钙离子成像系统检测不同浓度NMDA(100~500 μmol/L)对原代培养的大鼠颅盖骨成骨细胞[Ca^2+]i水平的影响和NMDA受体非竞争性拮抗剂MK801(Dizocilpin,地佐西平)干预后的细胞[Ca^2+]i水平。结果不同浓度的NMDA导致不同程度和不同方式的细胞内[Ca^2+]i增加,各浓度NMDA引起成骨细胞[Ca2+]i一过性增加之后还可引起继发性变化(钙震荡或缓慢持续升高)。MK801不同程度地抑制NMDA诱导的[Ca^2+]i增加。结论原代培养的大鼠颅盖骨成骨细胞表达丰富的功能性NMDA受体,并且对不同浓度的NMDA呈不同方式和程度的[Ca^2+]i增加。MK-801对其不完全阻断的作用特点,提示原代培养的大鼠颅盖骨成骨细胞的NMDA受体与中枢神经系统相比其通道性质有所不同。

林权确权登记历史遗留问题及解决方法

通过对黎川县林权登记信息全面梳理和摸排,以数据整合为主线和抓手,发现问题。采取内业核实与外业核查调查等方式,分析登记信息、权属重叠、地类冲突、确权程序、已登未发证等情况,探索权登记中存在的难点和堵点,提出了解决问题的方法。

Chronicβ-Citronellol Inhalation Rescues Parvalbumin Expression Loss in Prefrontal Cortex of Chronic Restraint Stress Mice

Considerable evidence has revealed that essential oils and their main constituents possess anti-depressant and anxiolytic properties.In the current study,we report the effect ofβ-citronellol,the main component of rose essential oil,on depressive-like and anxiety-like behaviors in chronic restraint stress(CRS)mice.We found that chronic inhalation ofβ-citronellol for 14 days could increase locomotor activity in the open field test,decrease the percentage of immobility duration in the forced swimming test,and increase open arms exploration in elevated plus-maze test in CRS mice.Western blot experiment shows that chronicβ-citronellol inhalation rescues parvalbumin(PV)expression loss in the prefrontal cortex(PFC)of CRS mice.Correlation analysis reveals a strong relationship between the PV expression in PFC and the percentage of sucrose preference of the mice.These findings indicate the relationships between the PV gene expression of PFC and the effects ofβ-citronellol inhalation.