目的探讨右美托咪定(Dex)对奥沙利铂(Oxa)致神经性疼痛的镇痛作用及其机制。方法采用单剂量Oxa腹腔注射诱发大鼠神经性疼痛模型。SD大鼠随机分为4组:空白对照组(control组)、神经性疼痛组(model组)、右美托咪定处理组(Dex组)、右美托咪...目的探讨右美托咪定(Dex)对奥沙利铂(Oxa)致神经性疼痛的镇痛作用及其机制。方法采用单剂量Oxa腹腔注射诱发大鼠神经性疼痛模型。SD大鼠随机分为4组:空白对照组(control组)、神经性疼痛组(model组)、右美托咪定处理组(Dex组)、右美托咪定+阿替美唑组(Ati组)。在行为学上检测各组大鼠机械痛阈值(PWT)和冷热痛阈值(TWL);应用免疫印记法和免疫荧光法检测大鼠脊髓p-STAT3的蛋白表达。结果与control组比较,model组和Ati组PWT和TWL(冷)显著性缩短(P<0.05);脊髓p-STAT3的表达水平显著性增加(P<0.01)。与model组比较,Dex处理后60~120 min PWT和TWL(冷)显著性延长(P<0.05);脊髓p-STAT3的表达显著性减少(P<0.01)。与Dex组比较,Ati组在Dex处理后60~120 min PWT和TWL(冷)显著性缩短(P<0.05),而脊髓p-STAT3的表达显著性增加(P<0.05)。结论 Dex可通过抑制大鼠脊髓p-STAT3的增长,缓解Oxa所致的神经性疼痛。展开更多
In order to solve the current situation that unmanned aerial vehicles(UAVs)ignore safety indicators and cannot guarantee safe operation when operating in low-altitude airspace,a UAV route planning method that consider...In order to solve the current situation that unmanned aerial vehicles(UAVs)ignore safety indicators and cannot guarantee safe operation when operating in low-altitude airspace,a UAV route planning method that considers regional risk assessment is proposed.Firstly,the low-altitude airspace is discretized based on rasterization,and then the UAV operating characteristics and environmental characteristics are combined to quantify the risk value in the low-altitude airspace to obtain a 3D risk map.The path risk value is taken as the cost,the particle swarm optimization-beetle antennae search(PSO-BAS)algorithm is used to plan the spatial 3D route,and it effectively reduces the generated path redundancy.Finally,cubic B-spline curve is used to smooth the planned discrete path.A flyable path with continuous curvature and pitch angle is generated.The simulation results show that the generated path can exchange for a path with a lower risk value at a lower path cost.At the same time,the path redundancy is low,and the curvature and pitch angle continuously change.It is a flyable path that meets the UAV performance constraints.展开更多
文摘目的探讨右美托咪定(Dex)对奥沙利铂(Oxa)致神经性疼痛的镇痛作用及其机制。方法采用单剂量Oxa腹腔注射诱发大鼠神经性疼痛模型。SD大鼠随机分为4组:空白对照组(control组)、神经性疼痛组(model组)、右美托咪定处理组(Dex组)、右美托咪定+阿替美唑组(Ati组)。在行为学上检测各组大鼠机械痛阈值(PWT)和冷热痛阈值(TWL);应用免疫印记法和免疫荧光法检测大鼠脊髓p-STAT3的蛋白表达。结果与control组比较,model组和Ati组PWT和TWL(冷)显著性缩短(P<0.05);脊髓p-STAT3的表达水平显著性增加(P<0.01)。与model组比较,Dex处理后60~120 min PWT和TWL(冷)显著性延长(P<0.05);脊髓p-STAT3的表达显著性减少(P<0.01)。与Dex组比较,Ati组在Dex处理后60~120 min PWT和TWL(冷)显著性缩短(P<0.05),而脊髓p-STAT3的表达显著性增加(P<0.05)。结论 Dex可通过抑制大鼠脊髓p-STAT3的增长,缓解Oxa所致的神经性疼痛。
基金supported by the National Natural Science Foundation of China(61601497)the Natural Science Basic Research Plan in Shaanxi Province of China(2022JM-412)the Air Force Engineering University Principal Fund(XZJ2020005).
文摘In order to solve the current situation that unmanned aerial vehicles(UAVs)ignore safety indicators and cannot guarantee safe operation when operating in low-altitude airspace,a UAV route planning method that considers regional risk assessment is proposed.Firstly,the low-altitude airspace is discretized based on rasterization,and then the UAV operating characteristics and environmental characteristics are combined to quantify the risk value in the low-altitude airspace to obtain a 3D risk map.The path risk value is taken as the cost,the particle swarm optimization-beetle antennae search(PSO-BAS)algorithm is used to plan the spatial 3D route,and it effectively reduces the generated path redundancy.Finally,cubic B-spline curve is used to smooth the planned discrete path.A flyable path with continuous curvature and pitch angle is generated.The simulation results show that the generated path can exchange for a path with a lower risk value at a lower path cost.At the same time,the path redundancy is low,and the curvature and pitch angle continuously change.It is a flyable path that meets the UAV performance constraints.
