The emergency room is the primary place for critically ill patients to seek medical treatment[1].China is the world’s most densely populated country,and its regional development is extremely uneven.The emergency serv...The emergency room is the primary place for critically ill patients to seek medical treatment[1].China is the world’s most densely populated country,and its regional development is extremely uneven.The emergency service supply of first-class hospitals in cities,especially megacities,is still not in line with the demand for medical treatment,and the emergency rescue unite quipment and personnel allocation are facing challenges[2].展开更多
Objective This study aimed to investigate the genetic background of mitochondrial genes in young patients with Coronary heart disease (CHD) to provide a foundation for the early prevention of young patients with CHD...Objective This study aimed to investigate the genetic background of mitochondrial genes in young patients with Coronary heart disease (CHD) to provide a foundation for the early prevention of young patients with CHD. Methods 115 cases of young (〈 45 years) CHD Chinese Han patients (case group), 100 cases of older (〉 45 years) Chinese Hart CHD patients (experimental group) hospitalized and 100 cases of healthy people through physical examination (control group) at the General Hospital of PLA between January 2014 and December 2015 were selected. General information, clinical assessment, pedigree analysis, and mitochondrial full sequence scanning were performed. The pedigrees of one patient harbouring the C5263T mutation were recruited. Mitochondrial functional analysis including cellular reactive oxygen species (ROS) levels and mitochondrial membrane potential (MMP) were performed on pedigrees with the C5263T mutation (mutation group) and without the mutation (non-mutation group). Results The differences in biochemical tests (P 〉 0.05) between the case group and experimental group were not significant. The C5263T single-nucleotide mutation of the mitochondrial ND2 gene was observed in 2 young CHD patients in the case group. The premature CHD of these 2 patients followed a pattern of maternal inheritance. The mutation group (11, 112) had higher ROS levels (4750.82±1045.55 vs. 3888.58 ± 487.60, P= 0.022) and lower MMP levels (P= 0.045) than the non-mutation group (II1, III1, III2). Conclusion We speculated that the mitochondrial C5263T mutation might be associated with the occurrence CHD in Chinese Hart young people.展开更多
In recent years, more attentions have been paid to the association between climate change and human health. Increasing and more variable global surface temperature is one of the key climatic change factors which have ...In recent years, more attentions have been paid to the association between climate change and human health. Increasing and more variable global surface temperature is one of the key climatic change factors which have been consistently reported about the effect on human health. So far, more researches have revealed that temperature lead not only to direct deaths and illnesses but also to aggravation of cardiovascular and respiratory diseases. Typically, the relationship between temperature and mortality or morbidity is V-, U-, or J- shaped, with optimum temperature corresponding to the lowest point in the temperature mortality curve.展开更多
基金partly supported by the National Natural Science Foundation of China[Nos.81701961 and 71103014]the National Key Research and Development Plan for Science and Technology for the Winter Olympics of the Ministry of Science and Technology of China[No.2019YFF030058]。
文摘The emergency room is the primary place for critically ill patients to seek medical treatment[1].China is the world’s most densely populated country,and its regional development is extremely uneven.The emergency service supply of first-class hospitals in cities,especially megacities,is still not in line with the demand for medical treatment,and the emergency rescue unite quipment and personnel allocation are facing challenges[2].
基金supported by Chinese National Natural Science Fund(no.81670467)the Beijing Natural Science Fund(no.7152136)
文摘Objective This study aimed to investigate the genetic background of mitochondrial genes in young patients with Coronary heart disease (CHD) to provide a foundation for the early prevention of young patients with CHD. Methods 115 cases of young (〈 45 years) CHD Chinese Han patients (case group), 100 cases of older (〉 45 years) Chinese Hart CHD patients (experimental group) hospitalized and 100 cases of healthy people through physical examination (control group) at the General Hospital of PLA between January 2014 and December 2015 were selected. General information, clinical assessment, pedigree analysis, and mitochondrial full sequence scanning were performed. The pedigrees of one patient harbouring the C5263T mutation were recruited. Mitochondrial functional analysis including cellular reactive oxygen species (ROS) levels and mitochondrial membrane potential (MMP) were performed on pedigrees with the C5263T mutation (mutation group) and without the mutation (non-mutation group). Results The differences in biochemical tests (P 〉 0.05) between the case group and experimental group were not significant. The C5263T single-nucleotide mutation of the mitochondrial ND2 gene was observed in 2 young CHD patients in the case group. The premature CHD of these 2 patients followed a pattern of maternal inheritance. The mutation group (11, 112) had higher ROS levels (4750.82±1045.55 vs. 3888.58 ± 487.60, P= 0.022) and lower MMP levels (P= 0.045) than the non-mutation group (II1, III1, III2). Conclusion We speculated that the mitochondrial C5263T mutation might be associated with the occurrence CHD in Chinese Hart young people.
基金supported by the Gong-Yi Program of China Meteorological Administration (GYHY201106034)the National Science & Technology Infrastructure Foundation of China (2005DKA32403)the National Key Project of the Scientific and Technical Supporting Programs (2012BAJ18B08)
文摘In recent years, more attentions have been paid to the association between climate change and human health. Increasing and more variable global surface temperature is one of the key climatic change factors which have been consistently reported about the effect on human health. So far, more researches have revealed that temperature lead not only to direct deaths and illnesses but also to aggravation of cardiovascular and respiratory diseases. Typically, the relationship between temperature and mortality or morbidity is V-, U-, or J- shaped, with optimum temperature corresponding to the lowest point in the temperature mortality curve.