Background Hypertension is one of the most common chronic diseases which threatens human health. However,epidemic data of hypertension guided by new ACC hypertension guideline is limited. Methods Residents from four c...Background Hypertension is one of the most common chronic diseases which threatens human health. However,epidemic data of hypertension guided by new ACC hypertension guideline is limited. Methods Residents from four cities in urban and country areas were enrolled by the probability proportional to size method in Guangdong province,China. Results A total of 19,031 participants were enrolled. The age-standardized prevalence of hypertension was 32.07% guided by previous guideline and 56.67%guided by the new guideline. Notably,when guided by new guideline,the prevalence of hypertension in younger(15~24 years,313%;25~34 years,270%;35~44 years,186%),lower body mass index(BMI<24 kg/m^2,102%)and high-educated(undergraduates,194%;postgraduates,137%)participants increased more compared to older(55~64 years,47%;65~74 years,33%;75~84 years,23%),obesity(BMI≥28 kg/m^2,46.6%)and low-educated(primary school,42%)participants. Age,gender,alcohol taking,BMI,waist circumference,education,medical insurance and hypertension family history were found to be independent risk factors of hypertension in new guidelines. Conclusions The prevalence of hypertension changed greatly when guided by the new hypertension guideline. When applying the new hypertension guideline,subjects with younger age,lower BMI and high-educated tend to be more susceptible to hypertension compared to traditional high risk population. Further studies are needed to explore indicators that can predict the morbidity of hypertension.展开更多
Background Non-dipping blood pressure(BP)pattern is a potential risk factor contributing to cardiac geometry change.Relationship between BP pattern and left atrium(LA)enlargement besides left ventricle(LV)structural c...Background Non-dipping blood pressure(BP)pattern is a potential risk factor contributing to cardiac geometry change.Relationship between BP pattern and left atrium(LA)enlargement besides left ventricle(LV)structural change is seldom studied.Methods A total of 237 hypertensive and hospitalized adults were enrolled.Left heart chamber parameters were measured by 2-dimensional echocardiography,and BP circadian rhythm was evaluated by 24-hour ambulatory blood pressure monitoring.Night-day ratios of systolic BP(NDR-SBP)were calculated and BP patterns were classified into dippers,reduced-dippers,and risers,which were defined as NDR-SBP<0.9,≥0.9 and<1,≥1,respectively.Multiple logistic regression analyses were performed to identify the factors associated with increased left ventricular end-diastolic internal diameter and left atrial diameter.Results Among enrolled participants,there were 62(26.2%)dippers,136(57.4%)reduced-dippers and 39(16.5%)risers.Briefly,57.8%were male and the mean age was 57.0±13.9 years.Compared to the dippers,both left ventricular end-diastolic diameter(44.4±4.3 mm in dippers,45.5±4.0 mm in reduced-dippers,46.5±4.5 mm in risers,P=0.045)and left atrial diameter(32.7±4.1 mm in dippers,34.3±4.7 mm in reduced-dippers,35.7±4.3 mm in risers,P=0.004)were progressively increased in reduced-dippers and risers.Logistic regression analyses showed that after adjusted for age,male gender,history of diabetes,blood lipid profiles,mean diurnal BP and estimated glomerular filtration rate,the association between increased LV diameter and riser BP pattern was significant(OR:2.621,95%CI:1.030-6.678)while the association between increased LA diameter and riser BP pattern was marginally significant.Conclusions The riser BP pattern is associated with the enlargement of LV and probably that of LA in hypertensive patients independent of 24-hour systolic BP level.展开更多
基金the Natural Science Foundation of Guangdong Province(No.2015A030313660)the Science and Technology Program of Guangzhou(No.201803040012/No.201604020143/No.201604020018/No.201510010254/No.201604020186)+3 种基金the Medical Science and Technology Research Fund of Guangdong Province(No.B2018023)the National Key Research and Development Program of China(No.2017FYC1307603/No.2016YFC1301305)the Science and Technology Program of Guangdong Province(No.2017B030314041/No.2014B020212008)the Key Area R&D Program of Guangdong Province(No.2019B020227005).
文摘Background Hypertension is one of the most common chronic diseases which threatens human health. However,epidemic data of hypertension guided by new ACC hypertension guideline is limited. Methods Residents from four cities in urban and country areas were enrolled by the probability proportional to size method in Guangdong province,China. Results A total of 19,031 participants were enrolled. The age-standardized prevalence of hypertension was 32.07% guided by previous guideline and 56.67%guided by the new guideline. Notably,when guided by new guideline,the prevalence of hypertension in younger(15~24 years,313%;25~34 years,270%;35~44 years,186%),lower body mass index(BMI<24 kg/m^2,102%)and high-educated(undergraduates,194%;postgraduates,137%)participants increased more compared to older(55~64 years,47%;65~74 years,33%;75~84 years,23%),obesity(BMI≥28 kg/m^2,46.6%)and low-educated(primary school,42%)participants. Age,gender,alcohol taking,BMI,waist circumference,education,medical insurance and hypertension family history were found to be independent risk factors of hypertension in new guidelines. Conclusions The prevalence of hypertension changed greatly when guided by the new hypertension guideline. When applying the new hypertension guideline,subjects with younger age,lower BMI and high-educated tend to be more susceptible to hypertension compared to traditional high risk population. Further studies are needed to explore indicators that can predict the morbidity of hypertension.
基金supported by the Key Area R&D Program of Guangdong Province(No.2019B020227005)National Key Research and Development Program of China(No.2016YFC1301202)。
文摘Background Non-dipping blood pressure(BP)pattern is a potential risk factor contributing to cardiac geometry change.Relationship between BP pattern and left atrium(LA)enlargement besides left ventricle(LV)structural change is seldom studied.Methods A total of 237 hypertensive and hospitalized adults were enrolled.Left heart chamber parameters were measured by 2-dimensional echocardiography,and BP circadian rhythm was evaluated by 24-hour ambulatory blood pressure monitoring.Night-day ratios of systolic BP(NDR-SBP)were calculated and BP patterns were classified into dippers,reduced-dippers,and risers,which were defined as NDR-SBP<0.9,≥0.9 and<1,≥1,respectively.Multiple logistic regression analyses were performed to identify the factors associated with increased left ventricular end-diastolic internal diameter and left atrial diameter.Results Among enrolled participants,there were 62(26.2%)dippers,136(57.4%)reduced-dippers and 39(16.5%)risers.Briefly,57.8%were male and the mean age was 57.0±13.9 years.Compared to the dippers,both left ventricular end-diastolic diameter(44.4±4.3 mm in dippers,45.5±4.0 mm in reduced-dippers,46.5±4.5 mm in risers,P=0.045)and left atrial diameter(32.7±4.1 mm in dippers,34.3±4.7 mm in reduced-dippers,35.7±4.3 mm in risers,P=0.004)were progressively increased in reduced-dippers and risers.Logistic regression analyses showed that after adjusted for age,male gender,history of diabetes,blood lipid profiles,mean diurnal BP and estimated glomerular filtration rate,the association between increased LV diameter and riser BP pattern was significant(OR:2.621,95%CI:1.030-6.678)while the association between increased LA diameter and riser BP pattern was marginally significant.Conclusions The riser BP pattern is associated with the enlargement of LV and probably that of LA in hypertensive patients independent of 24-hour systolic BP level.
