期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Comparative Proteomic Analysis in Left Ventricular Remodeling following Myocardial Infarction in Rats 被引量:2
1
作者 GU Hong Juan GAO Chang Bin +3 位作者 GONG jun li li xiang jun SUN Bo li Xi Ning 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2012年第1期117-123,共7页
Objective Left ventricular remodeling (LVR) following myocardial infarction (MI) is a key pathophysiological process in which MI develops into heart failure. The exact mechanism of LVR remains unclear. We performe... Objective Left ventricular remodeling (LVR) following myocardial infarction (MI) is a key pathophysiological process in which MI develops into heart failure. The exact mechanism of LVR remains unclear. We performed differential proteomic analysis on the myocardia of rats with LVR after MI, to explore the mechanism of ventricular remodeling after MI. Methods In the LVR group (n=12), after the anterior descending coronary artery was ligated, the rats were fed for four weeks before the LVR models were established. Rats in the sham-operated group (n=11) underwent thread-drawing without ligation. The hemodynamic parameters, pathological findings, and proteomics were compared between the two groups. Results In the LVR group, the left ventricular end-diastolic pressure increased, the maximal left ventricular pressure increase/decrease ratio decreased significantly, and the left ventricular systolic pressure decreased. H-E staining and Masson staining of cardiac muscle tissues of the LVR group showed myocytolysis, disarray, and collagen proliferation. Twenty-one differentially expressed proteins were detected by proteomic analysis. We validated two proteins using western blot analysis. The differentially expressed proteins could be divided into six categories: energy metabolism-related proteins, cytoskeletal proteins, protein synthesis-related proteins, channel proteins, anti-oxidation- related proteins, and immune-related proteins. Conclusion These differentially expressed proteins might play key roles in LVR following M 展开更多
关键词 Comparative proteomics Liquid chromatography-mass spectrometry Left ventricular remodeling Myocardial infarction Western blot
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部