目的:探讨全球斜外侧腰椎椎间融合术的研究现状及发展趋势,明确其研究方向及热点。方法:通过web of science核心合集检索对2012-01-01至2022-12-31斜外侧椎间融合术的文献进行统计和分析,运用VOS viewer进行文献耦合、关键词共现等分析O...目的:探讨全球斜外侧腰椎椎间融合术的研究现状及发展趋势,明确其研究方向及热点。方法:通过web of science核心合集检索对2012-01-01至2022-12-31斜外侧椎间融合术的文献进行统计和分析,运用VOS viewer进行文献耦合、关键词共现等分析OLIF的研究现状及发展趋势。结果:(1)共纳入357篇文献,斜外侧腰椎椎间融合术的全球年累计发文量呈指数式上涨阶段。(2)Kim.JS是最高产的著者,发表文献17篇,H指数26;《WORLD NEUROSURGERY》刊出相关文献64篇,在相关领域排第一;资助发文最多的基金为中国国家自然科学基金(35篇);韩国加图立大学是发文最多的机构;(3)从全球斜外侧腰椎椎间融合术的可视化分析看,中、美、韩、日本在斜外侧腰椎椎间融合术中的研究贡献最大。结论:OLIF仍然是脊柱融合研究的热点,后期还有很大的探索空间。目前研究聚焦点仍然在手术应用及其并发症。展开更多
目的建立角蛋白I型细胞骨架10[keratin type I cytoskeletal 10,KRT10)和VI型胶原蛋白A3[collagen alpha-3(VI)chain,COL6A3]短肽抗体的ELISA检测方法,并探讨两种瓜氨酸化短肽抗体在类风湿关节炎(rheumatoid arthritis,RA)实验室诊断中...目的建立角蛋白I型细胞骨架10[keratin type I cytoskeletal 10,KRT10)和VI型胶原蛋白A3[collagen alpha-3(VI)chain,COL6A3]短肽抗体的ELISA检测方法,并探讨两种瓜氨酸化短肽抗体在类风湿关节炎(rheumatoid arthritis,RA)实验室诊断中的价值。方法以合成短肽为包被抗原,抗人IgA,IgG及IgM为二抗,检测100例抗瓜氨酸化蛋白抗体(anti-citrullinated protein antibodies,ACPA)阳性组、100例健康对照组和29例RA确诊患者血清中的KRT10,KRT10_C,COL6A3及COL6A3_C短肽抗体水平,比较不同短肽抗体与RA的相关性,采用ROC曲线分析KRT10_C和COL6A3_C短肽抗体对于RA的诊断价值,并对此ELISA方法进行精密度评价。结果与临床诊断相比,KRT10_C短肽抗体诊断RA的灵敏度为58.62%,特异度为52.17%,用于诊断抗CCP抗体阳性RA患者的ROC曲线下面积达0.895;COL6A3_C短肽抗体诊断RA的灵敏度为65.52%,特异度为78.95%,用于诊断抗CCP抗体阴性的RA患者的ROC曲线下面积可达0.956。ELISA检测值KRT10_C(以抗人IgG为二抗)的批内变异系数分别为11.2%(低值)、7.8%(中值)和6.7%(高值)。ELISA检测COL6A3_C(以抗人IgM为二抗)的批内变异系数分别为12.9%(低值)、8.4%(中值)和8.9%(高值)。结论KRT10_C和COL6A3_C短肽抗体对RA诊断具有重要意义,有望加入并完善实验室诊断体系,提高RA的早期诊断率。展开更多
To support multi-factor decision problems about usability evaluation, especially when studies fall short of comparable objects, a fuzzy synthetic evaluation model is explored in this paper. Grey relational analysis （...To support multi-factor decision problems about usability evaluation, especially when studies fall short of comparable objects, a fuzzy synthetic evaluation model is explored in this paper. Grey relational analysis （GRA） is brought in the model to calculate weight vectors of the usability factors. And membership functions of a remark vector are constructed in the context of use of the operation interface. The present method is applied in usability evaluation of operation interface and is proved to be effective. The comprehensive usability gradation of the operation interface to good is 0. 616 4 that meets the requirements in practice.展开更多
Although grating fabrication technologies on solid materials are well developed,grating fabrication on free standing films is rather more difficult.We propose a new film grating fabrication method based on UV-nanoimpr...Although grating fabrication technologies on solid materials are well developed,grating fabrication on free standing films is rather more difficult.We propose a new film grating fabrication method based on UV-nanoimprint lithography.This method combines the grating fabrication technique using nanoimprint lithography with thin film preparation technology.It involves the fabrication of a PMMA grating by UV-nanoimprint lithography,followed by the preparation of a thin metal film on the PMMA grating and the patterning of the tensile film specimen through photolithography.After dissolving the PMMA layer,the tensile film specimen becomes a free standing structure.To identify the quality of the thin film specimen as well as the grating,the specimen is loaded with uniaxial tensile stress.The Moirémethod is adopted to measure the full-field deformation and the mechanical parameters of the film specimen.The successful results verify the potential of this method in grating fabrication on other film-like specimens.展开更多
Deep deterministic policy gradient(DDPG)has been proved to be effective in optimizing particle swarm optimization(PSO),but whether DDPG can optimize multi-objective discrete particle swarm optimization(MODPSO)remains ...Deep deterministic policy gradient(DDPG)has been proved to be effective in optimizing particle swarm optimization(PSO),but whether DDPG can optimize multi-objective discrete particle swarm optimization(MODPSO)remains to be determined.The present work aims to probe into this topic.Experiments showed that the DDPG can not only quickly improve the convergence speed of MODPSO,but also overcome the problem of local optimal solution that MODPSO may suffer.The research findings are of great significance for the theoretical research and application of MODPSO.展开更多
文摘目的:探讨全球斜外侧腰椎椎间融合术的研究现状及发展趋势,明确其研究方向及热点。方法:通过web of science核心合集检索对2012-01-01至2022-12-31斜外侧椎间融合术的文献进行统计和分析,运用VOS viewer进行文献耦合、关键词共现等分析OLIF的研究现状及发展趋势。结果:(1)共纳入357篇文献,斜外侧腰椎椎间融合术的全球年累计发文量呈指数式上涨阶段。(2)Kim.JS是最高产的著者,发表文献17篇,H指数26;《WORLD NEUROSURGERY》刊出相关文献64篇,在相关领域排第一;资助发文最多的基金为中国国家自然科学基金(35篇);韩国加图立大学是发文最多的机构;(3)从全球斜外侧腰椎椎间融合术的可视化分析看,中、美、韩、日本在斜外侧腰椎椎间融合术中的研究贡献最大。结论:OLIF仍然是脊柱融合研究的热点,后期还有很大的探索空间。目前研究聚焦点仍然在手术应用及其并发症。
文摘目的建立角蛋白I型细胞骨架10[keratin type I cytoskeletal 10,KRT10)和VI型胶原蛋白A3[collagen alpha-3(VI)chain,COL6A3]短肽抗体的ELISA检测方法,并探讨两种瓜氨酸化短肽抗体在类风湿关节炎(rheumatoid arthritis,RA)实验室诊断中的价值。方法以合成短肽为包被抗原,抗人IgA,IgG及IgM为二抗,检测100例抗瓜氨酸化蛋白抗体(anti-citrullinated protein antibodies,ACPA)阳性组、100例健康对照组和29例RA确诊患者血清中的KRT10,KRT10_C,COL6A3及COL6A3_C短肽抗体水平,比较不同短肽抗体与RA的相关性,采用ROC曲线分析KRT10_C和COL6A3_C短肽抗体对于RA的诊断价值,并对此ELISA方法进行精密度评价。结果与临床诊断相比,KRT10_C短肽抗体诊断RA的灵敏度为58.62%,特异度为52.17%,用于诊断抗CCP抗体阳性RA患者的ROC曲线下面积达0.895;COL6A3_C短肽抗体诊断RA的灵敏度为65.52%,特异度为78.95%,用于诊断抗CCP抗体阴性的RA患者的ROC曲线下面积可达0.956。ELISA检测值KRT10_C(以抗人IgG为二抗)的批内变异系数分别为11.2%(低值)、7.8%(中值)和6.7%(高值)。ELISA检测COL6A3_C(以抗人IgM为二抗)的批内变异系数分别为12.9%(低值)、8.4%(中值)和8.9%(高值)。结论KRT10_C和COL6A3_C短肽抗体对RA诊断具有重要意义,有望加入并完善实验室诊断体系,提高RA的早期诊断率。
基金supported by the Ph. D. Programs Foundation of Ministry of Education of China under Grant No. 20070968063
文摘To support multi-factor decision problems about usability evaluation, especially when studies fall short of comparable objects, a fuzzy synthetic evaluation model is explored in this paper. Grey relational analysis （GRA） is brought in the model to calculate weight vectors of the usability factors. And membership functions of a remark vector are constructed in the context of use of the operation interface. The present method is applied in usability evaluation of operation interface and is proved to be effective. The comprehensive usability gradation of the operation interface to good is 0. 616 4 that meets the requirements in practice.
基金Supported by the National Basic Research Program of China under Grant Nos 2010CB631005 and 2011CB606105the National Natural Science Foundation of China under Grant Nos 11172151 and 90916010the Specialized Research Fund for the Doctoral Program of Higher Education under Grant No 20090002110048.
文摘Although grating fabrication technologies on solid materials are well developed,grating fabrication on free standing films is rather more difficult.We propose a new film grating fabrication method based on UV-nanoimprint lithography.This method combines the grating fabrication technique using nanoimprint lithography with thin film preparation technology.It involves the fabrication of a PMMA grating by UV-nanoimprint lithography,followed by the preparation of a thin metal film on the PMMA grating and the patterning of the tensile film specimen through photolithography.After dissolving the PMMA layer,the tensile film specimen becomes a free standing structure.To identify the quality of the thin film specimen as well as the grating,the specimen is loaded with uniaxial tensile stress.The Moirémethod is adopted to measure the full-field deformation and the mechanical parameters of the film specimen.The successful results verify the potential of this method in grating fabrication on other film-like specimens.
文摘Deep deterministic policy gradient(DDPG)has been proved to be effective in optimizing particle swarm optimization(PSO),but whether DDPG can optimize multi-objective discrete particle swarm optimization(MODPSO)remains to be determined.The present work aims to probe into this topic.Experiments showed that the DDPG can not only quickly improve the convergence speed of MODPSO,but also overcome the problem of local optimal solution that MODPSO may suffer.The research findings are of great significance for the theoretical research and application of MODPSO.
