目的通过运用证据图系统检索并梳理近6年中药注射液治疗慢性阻塞性肺疾病(简称慢阻肺)的临床研究,了解中药注射液治疗慢阻肺的研究现状和研究质量。方法通过检索PubMed、Embase、Cochrane Library、Web of Science、中国知网(CNKI)、万...目的通过运用证据图系统检索并梳理近6年中药注射液治疗慢性阻塞性肺疾病(简称慢阻肺)的临床研究,了解中药注射液治疗慢阻肺的研究现状和研究质量。方法通过检索PubMed、Embase、Cochrane Library、Web of Science、中国知网(CNKI)、万方数据库(Wanfang)、中文科技期刊数据库(VIP)和中国生物医学文献服务系统(SinoMed)数据库里中药注射液治疗慢阻肺的相关文献,检索日期为2017年1月至2022年11月。采用图表结合文字的方式呈现并分析证据分布特征。最终纳入136篇临床研究文献,包括128篇干预性研究和8篇观察性研究。结果对纳入文献进行分析,共获得27种中药注射液,以痰热清注射液的使用频次最高,用药存在未经辨证论治或超说明书使用的情况。近年来发文量呈下降趋势,以单中心、小样本、短周期的临床试验居多,合并用药和结局指标种类较多,且文献质量普遍不高。结论需进一步规范临床用药与结局指标评定,充分发掘中医优势,提高随机对照试验研究的方法学质量,以便形成更多的高质量证据,为中药注射液治疗慢阻肺的有效性和安全性提供依据,促进中医药事业的发展。展开更多
Most vein minerals deposited in fractures of the Jialingjiang Formation from Libixia section, Hechan area include a large amount of saddle dolomite and accompanying celestite, calcite and fluorite. This study analyzed...Most vein minerals deposited in fractures of the Jialingjiang Formation from Libixia section, Hechan area include a large amount of saddle dolomite and accompanying celestite, calcite and fluorite. This study analyzed the nature, source, evolution of the fluids by plane-light petrography, fluid-inclusion methods, cathodoluminescence images, and stable isotopic compositions. The homogenization temperatures of two-phase aqueous fluid inclusions in dolomite range between 100 and 270℃. Combined with the jlSO data, it is suggested that the fluid responsible for the precipitation of fracture fillings have δ18O values between 10%o and 18‰ (relative to SMOW). The saddle dolomite and the accompanying minerals were the result of activity of dense brines at elevated temperatures. Moreover, analysis shows that the fluid was derived from a mixture of marine-derived brine and deeper circulating flow. This fluid was enriched in Sr during diagenesis and formed celestite in fracture and for regional mineralization. Dissolution of saddle dolomite was attributed to the cooling of Mg/Ca-decreased fluids, which may relate to a leaching of gypsum to celestite in surrounding carbonates.展开更多
文摘目的通过运用证据图系统检索并梳理近6年中药注射液治疗慢性阻塞性肺疾病(简称慢阻肺)的临床研究,了解中药注射液治疗慢阻肺的研究现状和研究质量。方法通过检索PubMed、Embase、Cochrane Library、Web of Science、中国知网(CNKI)、万方数据库(Wanfang)、中文科技期刊数据库(VIP)和中国生物医学文献服务系统(SinoMed)数据库里中药注射液治疗慢阻肺的相关文献,检索日期为2017年1月至2022年11月。采用图表结合文字的方式呈现并分析证据分布特征。最终纳入136篇临床研究文献,包括128篇干预性研究和8篇观察性研究。结果对纳入文献进行分析,共获得27种中药注射液,以痰热清注射液的使用频次最高,用药存在未经辨证论治或超说明书使用的情况。近年来发文量呈下降趋势,以单中心、小样本、短周期的临床试验居多,合并用药和结局指标种类较多,且文献质量普遍不高。结论需进一步规范临床用药与结局指标评定,充分发掘中医优势,提高随机对照试验研究的方法学质量,以便形成更多的高质量证据,为中药注射液治疗慢阻肺的有效性和安全性提供依据,促进中医药事业的发展。
基金supported by the National Natural Science Foundation of China(grants no.41272130 and 41172099)support provided by Key Laboratory for Sedimentary Basin and Oil and Gas Resources of MLR(grant no.zdsys2014003)
文摘Most vein minerals deposited in fractures of the Jialingjiang Formation from Libixia section, Hechan area include a large amount of saddle dolomite and accompanying celestite, calcite and fluorite. This study analyzed the nature, source, evolution of the fluids by plane-light petrography, fluid-inclusion methods, cathodoluminescence images, and stable isotopic compositions. The homogenization temperatures of two-phase aqueous fluid inclusions in dolomite range between 100 and 270℃. Combined with the jlSO data, it is suggested that the fluid responsible for the precipitation of fracture fillings have δ18O values between 10%o and 18‰ (relative to SMOW). The saddle dolomite and the accompanying minerals were the result of activity of dense brines at elevated temperatures. Moreover, analysis shows that the fluid was derived from a mixture of marine-derived brine and deeper circulating flow. This fluid was enriched in Sr during diagenesis and formed celestite in fracture and for regional mineralization. Dissolution of saddle dolomite was attributed to the cooling of Mg/Ca-decreased fluids, which may relate to a leaching of gypsum to celestite in surrounding carbonates.