目的分析宫颈黏液腺癌(mucinous adenocarcinoma of the uterine cervix)的MRI影像特点,探讨其影像诊断及分期价值。方法回顾性分析19例经手术病理证实的宫颈黏液腺癌患者临床和术前MRI影像资料;中位数年龄42(28~68)岁;病理诊断为普通...目的分析宫颈黏液腺癌(mucinous adenocarcinoma of the uterine cervix)的MRI影像特点,探讨其影像诊断及分期价值。方法回顾性分析19例经手术病理证实的宫颈黏液腺癌患者临床和术前MRI影像资料;中位数年龄42(28~68)岁;病理诊断为普通型宫颈黏液腺癌13例,胃型黏液腺癌4例,宫颈管型黏液腺癌2例。观察病变的形态学及信号特点、强化特点、宫旁受侵及淋巴结转移等情况,分析宫颈黏液腺癌不同病理亚型是否发生囊变及其生长方式。结果19例患者的病灶最大径为0.8~4.7cm,平均为(3.1±1.3)cm。肿瘤在较早期更倾向于宫颈管内或内生性生长;肿瘤较易出现囊变,囊内可富含黏液成分呈T1WI高信号;动态增强扫描9例呈病灶强化早于肌层,延迟期轻度强化,弱于肌层;宫颈受累情况:1例局限于宫颈管内,18例宫颈间质环及宫颈肌层不同程度受累;转移情况:宫体受侵9例,阴道受侵5例,卵巢受累2例,淋巴结受累5例。结论宫颈黏液腺癌的MRI影像表现有一定特点,可清晰显示病灶位置、大小、形态、与周围组织的关系及有无囊变,有助于宫颈病变定性及肿瘤分期。展开更多
Background The recombinant human bone morphogenetic protein 2 (rhBMP-2) has been used to induce osteogenesis in animals' middle ear and this technique is possible to be used to reconstruct the defects of ossicles. ...Background The recombinant human bone morphogenetic protein 2 (rhBMP-2) has been used to induce osteogenesis in animals' middle ear and this technique is possible to be used to reconstruct the defects of ossicles. The side effects of the rhBMP-2 in middle ear should be observed before using in clinic. Thus we prepared the controlled release rhBMP-2 and implanted it into the acoustic bulla of guinea pigs. The effect on the cochlea was observed. Methods We prepared the acellular cancellous bone, accompanied with rhBMP-2. The material accompanied with rhBMP-2 was implanted into one acoustic bulla of the animal and the opposite side of the acoustic bulla was implanted with acellular cancellous bone without rhBMP-2. Totally 20 guinea pigs were undergone this procedure. After the operation, the auditory brainstem response (ABR) of the animals was tested according to the time sequence. Three months after the operation, the animals were sacrificed. The osteogenesis induced by rhBMP-2, the acoustic bulla and cochlea affected by rhBMP-2 were observed. The structures of hair cells were observed after silver nitrate staining. Results The animals were recovered soon after surgery. The hearing thresholds of the animals were declined slightly just after the surgery and come back completely after 3 months. Also, the bulla and cochlea were normal in shape. The osteogenesis occurred in the pore of the acellular cancellous bone with rhBMP-2. There was not any abnormal hyperplasia of bone in the bulla and cochlea. The articulation between the stapes and oval window was not merged. The shapes of the hair cells were normal and there was no obvious deletion of the hair cells compared with control group. Conclusions The controlled release rhBMP-2 transplanted into the middle ear could induce osteogenesis in the bulla of the animals. It did not affect the shape of the bulla and the hearing threshold of the animal, and did not induce the abnormal hyperplasia of bone in the bulla and might be used to reconstruct the defects of ossicles.展开更多
To the Editor: Cystic fibrosis (CF) is quite rare in the Asian population that an epidemiological study in the Japanese population revealed the incidence of CF being about I in 350000.
文摘目的分析宫颈黏液腺癌(mucinous adenocarcinoma of the uterine cervix)的MRI影像特点,探讨其影像诊断及分期价值。方法回顾性分析19例经手术病理证实的宫颈黏液腺癌患者临床和术前MRI影像资料;中位数年龄42(28~68)岁;病理诊断为普通型宫颈黏液腺癌13例,胃型黏液腺癌4例,宫颈管型黏液腺癌2例。观察病变的形态学及信号特点、强化特点、宫旁受侵及淋巴结转移等情况,分析宫颈黏液腺癌不同病理亚型是否发生囊变及其生长方式。结果19例患者的病灶最大径为0.8~4.7cm,平均为(3.1±1.3)cm。肿瘤在较早期更倾向于宫颈管内或内生性生长;肿瘤较易出现囊变,囊内可富含黏液成分呈T1WI高信号;动态增强扫描9例呈病灶强化早于肌层,延迟期轻度强化,弱于肌层;宫颈受累情况:1例局限于宫颈管内,18例宫颈间质环及宫颈肌层不同程度受累;转移情况:宫体受侵9例,阴道受侵5例,卵巢受累2例,淋巴结受累5例。结论宫颈黏液腺癌的MRI影像表现有一定特点,可清晰显示病灶位置、大小、形态、与周围组织的关系及有无囊变,有助于宫颈病变定性及肿瘤分期。
基金This work was supported by grants from Beijing Medical Development Foundation (No. 2002-3075) and China Postdoctoral Science Foundation (No. 20080440224).
文摘Background The recombinant human bone morphogenetic protein 2 (rhBMP-2) has been used to induce osteogenesis in animals' middle ear and this technique is possible to be used to reconstruct the defects of ossicles. The side effects of the rhBMP-2 in middle ear should be observed before using in clinic. Thus we prepared the controlled release rhBMP-2 and implanted it into the acoustic bulla of guinea pigs. The effect on the cochlea was observed. Methods We prepared the acellular cancellous bone, accompanied with rhBMP-2. The material accompanied with rhBMP-2 was implanted into one acoustic bulla of the animal and the opposite side of the acoustic bulla was implanted with acellular cancellous bone without rhBMP-2. Totally 20 guinea pigs were undergone this procedure. After the operation, the auditory brainstem response (ABR) of the animals was tested according to the time sequence. Three months after the operation, the animals were sacrificed. The osteogenesis induced by rhBMP-2, the acoustic bulla and cochlea affected by rhBMP-2 were observed. The structures of hair cells were observed after silver nitrate staining. Results The animals were recovered soon after surgery. The hearing thresholds of the animals were declined slightly just after the surgery and come back completely after 3 months. Also, the bulla and cochlea were normal in shape. The osteogenesis occurred in the pore of the acellular cancellous bone with rhBMP-2. There was not any abnormal hyperplasia of bone in the bulla and cochlea. The articulation between the stapes and oval window was not merged. The shapes of the hair cells were normal and there was no obvious deletion of the hair cells compared with control group. Conclusions The controlled release rhBMP-2 transplanted into the middle ear could induce osteogenesis in the bulla of the animals. It did not affect the shape of the bulla and the hearing threshold of the animal, and did not induce the abnormal hyperplasia of bone in the bulla and might be used to reconstruct the defects of ossicles.
文摘To the Editor: Cystic fibrosis (CF) is quite rare in the Asian population that an epidemiological study in the Japanese population revealed the incidence of CF being about I in 350000.